Plasma Oxidized Low-Density Lipoprotein Is an Independent Risk Factor in Young Patients with Coronary Artery Disease

Abstract

Objectives: Oxidized low-density lipoprotein (ox-LDL) is considered to be a key factor of initiating and accelerating atherosclerosis. The objective of this study was to investigate the role of ox-LDL in young patients with coronary artery disease (CAD). Methods: 128 consecutive angiographically proven young CAD patients (aged ≤ 55 years) were enrolled, and 132 age-matched non-CAD individuals (coronary angiography normal or negative finding by coronary ultrafast CT) were set as control group. Conventional risk factors (hypertension, dyslipidemia, diabetes mellitus, obesity, smoking) were evaluated in the two groups. Ox-LDL was measured by competitive ELISA. Framingham risk score (FRS) and absolute 10-year CAD events risk were calculated for each individual. Results: Male sex was more prevalent in group CAD than in control (87.5% vs. 62.1%; P < 0.01). There were significant differences in smoking history (P < 0.01) and triglyeride (TG) and ratio of apolipoprotein B/apolipoprotein A1 (ApoB/ApoA1) (both P < 0.05) but no remarkable difference in other conventional risk factors (all P > 0.05) between group CAD and control. Level of ox-LDL was significantly higher in group CAD than in control (P < 0.01). Multivariate logistic regression showed that male sex (OR, 4.54; 95%CI, 1.76–9.77), smoking quantity (OR, 2.78; 95%CI, 1.34–4.25), TG (OR, 1.42; 95%CI, 1.18–2.83), ApoB/ApoA1 (OR, 1.73; 95%CI, 1.32–4.23), and ox-LDL (OR, 2.15; 95%CI, 1.37–6.95) were independently correlated with CAD in young patients. Area under the curve (AUC) of receiver operating characteristic (ROC) curve of TG, ApoB/ApoA1, and ox-LDL was 0.831, 0.866, and 0.935, respectively (P < 0.001). Conclusions: Ox-LDL is an important independent risk factor for CAD in young patients after adjusting other risk factors such as smoking, TG, and ApoB/ApoA1.

Impact of adiponectin and oxidized low-density lipoprotein in acute coronary syndrome

“…22,23 There is increasing evidence suggest that oxidative modification of LDL plays a pivotal role in the development of atherosclerosis. [24][25][26][27] This study found that the levels of ox-LDL were significantly higher in ACS cases than in healthy control group, which was similar to our previous findings. 26,27 These finding agree with the study mad by who found that Huiling Huang et al 28 These findings indicate that serum ox-LDL levels are closely related with CAD.…”

New Markers of Early Cardiovascular Risk in Multiple Sclerosis Patients: Oxidized-LDL Correlates with Clinical Staging

“…However (and even taking into account that our study did not focus on imagiological analysis), our data draw attention to the importance of measuring new markers of dyslipidemia (particularly Ox-LDL and small HDL), more reliably related with the disease and its progression, continuing to support the working hypothesis of thinking that the proinflammatory and thrombogenic mechanisms associated with an abnormal lipid profile could contribute to MS progression, through diverse processes at the BBB vascular endothelium. The relevance of "non-classic" markers of cardiovascular risk, such as oxidized LDL, has been increasingly demonstrated in young or adult subjects with coronary artery disease [26,27].…”

Metabolomic signature of arterial stiffness in male patients with peripheral arterial disease

“…7 Apart from metabolic alterations, abnormal oxidation of LDL is an important step in initiation and progression of atherosclerosis. 8 Recent research suggests that oxidized low-density lipoprotein (oxLDL) levels are increased in patients with coronary atherosclerosis 8 and PAD. 9 Recently, it has been shown that oxLDL is independently associated with 10-year risk of CAD events and improves the reclassification capacity of Framingham-derived risk functions.…”