Plasma phospholipid fatty acid composition and estimated desaturase activity in heart failure patients with metabolic syndrome

Abstract

Metabolic syndrome is one of the major factors to increase the incidence of heart failure. In our study, we compared plasma fatty acid compositions among heart failure patients with and without Metabolic syndrome. Fatty acid (FA) composition of plasma phospholipids was analyzed and the activities of desaturase were estimated as the ratio of substrate and product fatty acids in 85 stable heart failure patients. Fatty acid and estimated desaturase activities were further examined for their associations with Metabolic syndrome components. Heart failure patients with Metabolic syndrome showed significant changes in fatty acid composition in comparison to those without Metabolic syndrome, which had a decreased proportion of lauric acid (C12:0) and an increased proportion of dihomo-γ-linolenic acid (C20:3n-6). Also, estimated desaturase activities (D5D and D6D) were closely related to Metabolic syndrome condition among heart failure patients. The content of dihomo-γ-linolenic acid showed positive correlations with BMI, waist circumference, and plasma triglyceride levels. D6D were positively associated with plasma triglyceride levels, whereas D5D showed a negative correlation with plasma triglyceride levels and waist circumferences. The content of dihomo-γ-linolenic acid as well as estimated D6D and D5D were altered in heart failure patients with Metabolic syndrome.

Cardioprotective effect of virgin coconut oil in heated palm oil diet-induced hypertensive rats

“…The consumption of the fatty acid was shown to decrease the ratio of total cholesterol to high-density lipoprotein cholesterol (TC:HDL) in a study (Micha & Mozaffarian, 2010). While another study demonstrated that patients with heart failure together with metabolic syndrome had a lower proportion of lauric acid in addition to a higher proportion of dihomo-g-linolenic acid when compared with heart failure patients without metabolic syndrome (Lee et al, 2012). These reports might portray the beneficial effects of the lauric acid, hence the VCO on cardiovascular disease as well as metabolic syndrome.…”

Dietary Very Long Chain Saturated Fatty Acids and Metabolic Factors: Findings from the Korea National Health and Nutrition Examination Survey 2013

“…Previous studies, across the observational [ 5 6 7 ], prospective [ 8 9 ], and meta-analysis study designs [ 10 ], have speculated that type of dietary fat and plasma fatty acid (FA) composition contribute to development of insulin resistance and MetS. Furthermore, the intervention studies reported that a change of fat composition in diet affects on a composition of plasma FA as well as metabolic dysfunction [ 11 12 ].…”

Liver ACSM3 deficiency mediates metabolic syndrome via a lauric acid-HNF4α-p38 MAPK axis

“…Lauric acid could also upregulate Hnf4α, which activated Selenop transcription and repaired insulin-induced Akt phosphorylation (Kamoshita et al, 2022 ). Furthermore, heart failure patients with MetS displayed a higher proportion of lauric acid than heart failure patients without MetS (Lee et al, 2012 ). In a nonalcoholic fatty liver disease (NAFLD) cohort, higher lauric acid was significantly associated with a high NAFLD activity score in analyses adjusted for the same factors and fibrosis stage(Miyake et al, 2022 ).…”