Plasma Polymerized <i>N</i>-Isopropylacrylamide:  Synthesis and Characterization of a Smart Thermally Responsive Coating

Pan, Yayue; Wesley, Roger A.; Luginbühl, Reto; Denton, and Denice D.; Ratner, Buddy D.

doi:10.1021/bm0000642

Cited by 258 publications

(226 citation statements)

References 42 publications

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“…The peaks at 2877 cm -1 are -CH 3 symmetric stretching; 2934 cm -1 peak is for asymmetric -CH 2 -stretching; 2975 cm -1 peak is -CH 3 asymmetric stretching; 3437 cm -1 peak is N-H stretching, which is in accordance with PNIPAM. 14 The appearance of the characteristic absorption band of carboxyl group in curve G1, G2, and G3 of Figure 2 (1728 cm -1 ) is a strong evidence of incorporation of MAA into the copolymer microgel.…”

Section: Resultsmentioning

confidence: 86%

Preparation and Characterization of Novel Temperature and pH Sensitive (NIPAM-co-MAA) Polymer Microgels and Their Volume Phase Change with Various Salts

Khan¹,

Khan²,

Khan³

et al. 2013

Polymer Korea

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Novel microgels of N-isopropylacrylamide (NIPAM)-co-methacrylic acid (MAA) (NIPAM-co-MAA) with different contents of N,N-methylene bis acrylamide (MBA) were prepared by emulsion polymerization technique and were studied by Fourier transform infrared spectroscopy (FTIR), dynamic light scattering (DLS) and zeta potential measurement. Effect of pH, temperature and different salts concentration on the microgel particles was investigated. DLS results have shown that the hydrodynamic radius of the microgel increased upon increasing pH and decreased upon increasing temperature. The swelling/deswelling behaviors as determined by DLS showed the ionic repulsions of the carboxyl group of the methacrylic acid and hydrophobic interaction of NIPAM. The effect of various salts on volume phase transition temperature (VPTT) was also investigated. Upon increasing salt concentration, VPTT became broad and shifted to a lower temperature. Electrophoretic mobility measurements showed an increase with increasing pH and temperature at a constant ionic strength.

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Section: Resultsmentioning

confidence: 86%

Preparation and Characterization of Novel Temperature and pH Sensitive (NIPAM-co-MAA) Polymer Microgels and Their Volume Phase Change with Various Salts

Khan¹,

Khan²,

Khan³

et al. 2013

Polymer Korea

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“…41 To better assess whether the monomer structure is retained after plasma deposition, ToF-SIMS is used as a complementary technique, as it yields information regarding molecular species at interfaces. A representative ToF-SIMS positive ion spectrum of ppNIPAM in the range from m/z = 0 to 200 is shown in Figure 1(a) as very few peaks of interest are beyond this range.…”

Section: Tof-sims Analysis Of Surface Chemistrymentioning

confidence: 99%

Surface Chemical and Mechanical Properties of Plasma-Polymerized N-Isopropylacrylamide

et al. 2005

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Surface immobilized poly(N-isopropyl acrylamide) (pNIPAM) is currently used for a wide variety of biosensor and biomaterial applications. A thorough characterization of the surface properties of pNIPAM thin films will benefit those applications. In this work, we present analysis of a plasma polymerized NIPAM (ppNIPAM) coating by multiple surface analytical techniques, including timeof-flight secondary ion mass spectrometry (ToF-SIMS), contact angle measurement, atomic force microscopy (AFM) and sum frequency generation (SFG) vibrational spectroscopy. ToF-SIMS data show that the plasma-deposited NIPAM polymer on the substrate is crosslinked with a good retention of the monomer integrity. Contact angle results confirm the thermoresponse of the film as observed by a change of surface wettability as a function of temperature. Topographic and force distance curve measurements by AFM further demonstrate that the grafted film shrinks or swells depending on the temperature of the aqueous environment. A clear transition of the elastic modulus is observed at 31-32°C. The change of the surface wettability and mechanical properties vs. temperature are attributed to different conformations taken by the polymer, which is reflected on the outmost surface as distinct side chain groups orienting outwards at different temperatures as measured by SFG. The results suggest that a ppNIPAM thin film on a substrate experiences similar mechanical and chemical changes to pNIPAM bulk polymers in solution. The SFG result provides evidence supporting the current theory of the lower critical solution temperature (LCST) behavior of pNIPAM.

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“…The Al is patterned into 22 different 1cm 2 regions; these regions consist of continuous Al or various dot patterns that reduce lateral heat conduction through the metal layer. This wafer is conformally coated with approximately 50nm ppNIPAM [8]. 22 openings (footprint 1cm 2 ) are cut into a 4" diameter, 9mm thick polydimethylsiloxane (PDMS) mold that matches the Al patterns, and the mold is attached to the pyrex wafer such that it forms open chambers (volume 900µl) above each of the 22 patterns.…”

Section: Methodsmentioning

confidence: 99%

Infrared light induced patterning of proteins on ppNIPAM thermoresponsive thin films: a “protein laser printer”

et al. 2010

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Controlled adsorption and patterning of proteins on a thin film of thermo-responsive plasma-deposited poly-N-isopropylacrylamide occurs in response to heating with a computer-controlled infrared laser beam, with pattern resolution in the single micrometer range and adsorption times within a few seconds. Deposition of multiple proteins in the same substrate region has been accomplished. Successful streptavidin-biotin and antibody-antigen binding indicates that protein function stays intact after proteins adsorb to the ppNI-PAM bio-polymer surface.

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Plasma Polymerized N-Isopropylacrylamide: Synthesis and Characterization of a Smart Thermally Responsive Coating

Cited by 258 publications

References 42 publications

Preparation and Characterization of Novel Temperature and pH Sensitive (NIPAM-co-MAA) Polymer Microgels and Their Volume Phase Change with Various Salts

Preparation and Characterization of Novel Temperature and pH Sensitive (NIPAM-co-MAA) Polymer Microgels and Their Volume Phase Change with Various Salts

Surface Chemical and Mechanical Properties of Plasma-Polymerized N-Isopropylacrylamide

Infrared light induced patterning of proteins on ppNIPAM thermoresponsive thin films: a “protein laser printer”

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