Plasma Prolactin and Progesterone during the Estrous Cycle in the Mouse

Michael, Sandra D.

doi:10.3181/00379727-153-39522

Cited by 68 publications

(41 citation statements)

References 2 publications

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“…The phases during which surges of FSH, LH, and PRL occur in Mongolian gerbils are different from those of rats [30] and mice [20,23]. Contrary to the results of this study, FSH, LH, and PRL levels during the estrous cycle in Mongolian gerbils have been reported to peak at metestrus, estrus, and diestrus, respectively [27].…”

Section: Hormonal Variations During the Estrous Cycle In Virgin Mongocontrasting

confidence: 55%

Variations in Serum Gonadotropin and Prolactin Levels during Consecutive Reproductive States in Mongolian Gerbils (Meriones unguiculatus)

Shi

2011

Exp. Anim.

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Serum follicle-stimulating hormone (FSH), luteinizing hormone (LH), and prolactin (PRL) levels were examined during consecutive reproductive states in Mongolian gerbils. The results indicate that FSH, LH, and PRL levels peak at proestrus, estrus, and diestrus, respectively. During early gestation in primiparous gerbils, gonadotropin levels were the lowest on day 6. This was followed by an increase in FSH and LH levels until days 18 and 15, respectively, with levels remaining constant until day 21. However, in multiparous gerbils, gonadotropin levels were the lowest on day 12 of gestation and were relatively stable between days 15 to 21. In both primiparous and multiparous gerbils, gonadotropin levels increased rapidly from day 21 of gestation to day 3 of lactation, and kept stable between 6-24 days of lactation. PRL peaked during early gestation on days 9 and 6 in the primiparous and multiparous gerbils, respectively, followed by a decline. PRL levels subsequently peaked again on day 21 before parturition. During lactation, PRL levels peaked on days 6 and 9 in primiparous and multiparous gerbils, respectively, followed by a decline until lactation ended. These findings suggest that variations in gonadotropin during the estrous cycle, gestation, and lactation in Mongolian gerbils are similar to those observed in rats, whereas prolactin levels differ. Changes in gonadotropin and prolactin levels during different reproductive states were found to be similar in primiparous and multiparous gerbils, and were correlated with the reproductive stages of Mongolian gerbils.

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Section: Hormonal Variations During the Estrous Cycle In Virgin Mongocontrasting

confidence: 55%

Variations in Serum Gonadotropin and Prolactin Levels during Consecutive Reproductive States in Mongolian Gerbils (Meriones unguiculatus)

Shi

2011

Exp. Anim.

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“…Corticosterone inhibited and progesterone stimulated the intracellular degradation of insulin in the islets. The effects were detected at a steroid concentration of 1 µM, which is five to ten times higher than the normal plasma concentration in mice (Halberg et al, 1959;Solem, 1966;Michael, 1976;Bailey, 1987). However, in the present experiments the isolated islets had lost their microcirculation, and it is plausible that they had a low tissue extraction of the steroids.…”

Section: Discussioncontrasting

confidence: 38%

Steroid effects on intracellular degradation of insulin and crinophagy in isolated pancreatic islets

Sandberg¹,

Borg²

2007

Molecular and Cellular Endocrinology

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Please cite this article as: Sandberg, M., Borg, L.A.H., Steroid effects on intracellular degradation of insulin and crinophagy in isolated pancreatic islets, Molecular and Cellular Endocrinology (2007), doi:10.1016/j.mce.2007 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. The effects of corticosterone and progesterone on intracellular degradation of insulin and crinophagy were determined in pancreatic -cells, and possible pathways mediating these effects were evaluated. Pancreatic islets were isolated from mice, intracellular degradation of insulin was measured by a pulse-chase method, and crinophagy was studied by electron microscopy. The islets were exposed to 3.3, 5.5 or 28 mM glucose with or without corticosterone, progesterone or the receptor ligands A-224817.0 and WAY-161358.Mifepristone was used to block steroid receptors and indomethacin to inhibit prostaglandin synthesis. Corticosterone caused a concentration-dependent decrease of insulin degradation at the lower glucose concentrations. Progesterone effected a concentration-dependent stimulation of insulin degradation. These results were paralleled with changes of the crinophagic activity in the -cells. Corticosterone decreased and progesterone increased islet production of prostaglandin E 2 . Mifepristone abolished the steroid actions on insulin degradation and prostaglandin production. The effects of corticosterone were mimicked by the selective glucocorticoid receptor modulator A-224817.0, but in contrast to progesterone, the selective progesterone receptor agonist WAY-161358 had no effect on insulin degradation or prostaglandin production. Inhibition of cyclooxygenase blocked insulin degradation. The findings indicate that both corticosterone and progesterone could affect intracellular insulin degradation and crinophagy solely via the glucocorticoid receptor, and that prostaglandins may have a regulatory role in intracellular turnover of secretory material in pancreatic islet -cells.

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“…The male type of prolactin cell was reported to convert to the female type under the influence of the ovary in mice (23). In the present study, the pituitary gland in female mice was investigated only during metestrus because serum prolactin level and pituitary contents of prolactin were found to change during the estrous cycle (12,28).…”

Section: Discussionmentioning

confidence: 99%

Immunohistochemical identification of prolactin-producing cells in the mouse adenohypophysis.

Harigaya

Kohmoto

Hoshino

1983

Acta Histochem. Cytochem

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Plasma Prolactin and Progesterone during the Estrous Cycle in the Mouse

Cited by 68 publications

References 2 publications

Variations in Serum Gonadotropin and Prolactin Levels during Consecutive Reproductive States in Mongolian Gerbils (Meriones unguiculatus)

Variations in Serum Gonadotropin and Prolactin Levels during Consecutive Reproductive States in Mongolian Gerbils (Meriones unguiculatus)

Steroid effects on intracellular degradation of insulin and crinophagy in isolated pancreatic islets

Immunohistochemical identification of prolactin-producing cells in the mouse adenohypophysis.

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