Plasma pyridoxal 5′-phosphate is a significant indicator of immune responses in the mechanically ventilated critically ill

Vitamin B6 supplementation increases immune responses in critically ill patients

“…Quasim et al (2005), therefore, suggested that direct measurements of red cell PLP are more responsive to supplementation than plasma measurements in the critically ill patients. That might be the reason why there was no correlation between vitamin B 6 intake and plasma PLP concentration in our two previous studies (Huang et al, 2002;Huang et al, 2005). Critically ill patients consumed approximately 4 mg/day of vitamin B 6 , and a marginal plasma PLP deficiency (B20 nmol/l) and abnormal immune responses were still observed (Huang et al, 2005).…”

“…That might be the reason why there was no correlation between vitamin B 6 intake and plasma PLP concentration in our two previous studies (Huang et al, 2002;Huang et al, 2005). Critically ill patients consumed approximately 4 mg/day of vitamin B 6 , and a marginal plasma PLP deficiency (B20 nmol/l) and abnormal immune responses were still observed (Huang et al, 2005). We, therefore, gave a large amount of vitamin B 6 to our critically ill patients, finding total vitamin B 6 intake (dietary plus supplementation) significantly correlated with plasma PLP concentration.…”

“…Plasma PLP has been shown to be a significant indicator of immune responses in critically ill patients in our recent study (Huang et al, 2005). However, the effect of vitamin B 6 supplementation on immune responses in immunocompromised subgroups within the population (i.e., elderly, ill patients) has been seldom reported.…”

“…Critically ill patients were under severe stress, inflammation, and clinical conditions, which may increase the utilization and metabolic turnover of plasma PLP or even cause the redistribution of PLP from plasma to erythrocyte (Louw et al, 1992;Talwar et al, 2003a;Huang et al, 2005). It thus would be interesting to know whether a high dose of vitamin B 6 supplement would increase the immune response of critically ill patients.…”

Vitamin B6 supplementation improves pro-inflammatory responses in patients with rheumatoid arthritis

“…Previous studies (Roubenoff et al, 1995;Galloway et al, 2000;Friso et al, 2001;Chiang et al, 2003;Talwar et al, 2003;Huang et al, 2005;Cheng et al, 2008) have indicated that lower plasma plasma pyridoxal 5 0 -phosphate (PLP) is associated with increased levels of pro-inflammatory cytokine (that is, tumor necrosis factor-a (TNF-a)) and inflammatory markers (that is, C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR)). Low vitamin B 6 status due to inflammation might be caused by plasma PLP acting as a coenzyme for the production of cytokines and other polypeptide mediators during the inflammatory response (Friso et al, 2001).…”