Plasma rich in growth factors (PRGF) in non-surgical periodontal therapy: a randomized clinical trial

Panda, Santosh Kumar; Purkayastha, Adrita; Mohanty, Rinkee; Nayak, Rashmita; Satpathy, Anurag; Das, Abhaya Chandra; Kumar, Manoj; Mohanty, Gatha; Panda, Sital; Fabbro, Massimo Del

doi:10.1590/1807-3107bor-2020.vol34.0034

Cited by 20 publications

(14 citation statements)

References 33 publications

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“…Generally autogenous bone graft or any platelet concentrates is ideal regenerating materials. [9][10][11] But to harvest autogenous bone graft makes a secondary surgical site. For that reason we placed synthetic alloplastic material{DM bone (Silicon Ion Containing 60% HA, 40% B-TCP), META-BIOMED CO., LTD, Osongsaengmyeong, Republic of Korea} in the defect.…”

Section: Discussionmentioning

confidence: 99%

Management of Endo-perio Lesion by Guided Tissue Regeneration: A Case Report

2020

IJFMT

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To diagnose and to treat, is a crucial part of management of an endo-perio lesion. The sign and symptoms of endo-perio lesion are difficult to accountable for a general dental surgeon. For that reason, it needs more detailed examination and definite treatment plan. The outcomes of endo-perio lesion are highly unpredictable due its multiple etiological factors. The primary and secondary etiological factors of endo-perio lesions may have numerous variation and ultimately concludes the definite treatment plan complex. A 43-year-old female patientcame to Department of Periodontics, with a chief complaint of pain in right posterior lower tooth region.On clinical examination, there was 5mm of periodontal pocket, occlusal restoration in 47. The treatment plan was made as first endodontic treatment followed by periodontal treatment. So endodontic treatment was carried out first in 47 after oral prophylaxis. Then under local anesthesia, open debridement was done in 47 and bone graft was placed in the defect. Resorbable membrane was placed over the graft. Suture was placed and periodontal dressing was given and followed up to 9 months. She was very satisfied with the result.

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Section: Discussionmentioning

confidence: 99%

Management of Endo-perio Lesion by Guided Tissue Regeneration: A Case Report

2020

IJFMT

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“…PRGF is a second-generation blood-related product, similar to PRP, and requires less venous blood, making it convenient, time-consuming, safe, easy-to-use, and fast healing [ 91 ]. In contrast to PRP, PRGF does not contain white blood cells and associated inflammatory byproducts for avoiding the proinflammatory effects of proteases and acid hydrolases [ 92 ].…”

Section: Therapeutics For Periodontal Wound Healingmentioning

confidence: 99%

“…Due to its gel-like consistency, it seems more ideal for non-surgical application than surgical. In randomized clinical trials, the clinical efficacy of PRGF as an adjunct to non-surgical periodontal treatment has been proved with a reduction in pocket depth and gain in clinical attachment level [ 91 ]. Even in surgical procedures, the use of liquid PRGF accelerates bone healing in the extraction socket and sinus lift and promotes the osseointegration of dental implants [ 88 ].…”

Section: Therapeutics For Periodontal Wound Healingmentioning

confidence: 99%

Periodontal Wound Healing and Tissue Regeneration: A Narrative Review

et al. 2021

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Periodontal disease is a major public health issue, and various periodontal therapies have been performed to regenerate periodontal tissues. The periodontium is a complex structure composed of specialized tissues that support the teeth, and most periodontal surgeries are invasive procedures, including a resection of the gingiva or the alveolar bone. The periodontal wound healing process is slightly different from cutaneous wound healing and is similar to fetal healing, being almost scar-free. The aim of this review article is to provide an overview of periodontal wound healing and discuss various surgical and pharmaceutical approaches to achieve stable wound healing and improve the treatment outcomes. In addition, detrimental and limiting factors that induce a compromised prognosis are discussed, along with the perspective and future direction for successful periodontal tissue regeneration.

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“…PRGF, as already mentioned before is devoid of white blood cells and other pro-inflammatory products. 31 They also have a rich source of plateletderived growth factors that are usually released during the healing of a wound on the activation of platelets. In an in vitro study done by Anitua et al in 2009 stated that the proliferation rate of fibroblasts was increased in the presence of PRGF.…”

Section: Effect Of Prgf On Soft Tissue Regenerationmentioning

confidence: 99%

Role of PRGF (Plasma Rich in Growth Factors) in Periodontal Regeneration

Mohit Das,

Abhaya Chandra Das,

Sourav Panda

et al. 2021

Indian Journal of Forensic Medicine & Toxicology

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Platelet-rich-growth-factors (PRGF), a modification of fibrin glue made from autologous blood, is being used to deliver growth factors in high concentration to sites requiring osseous grafting. Growth factors released from the platelets include platelet-derived growth factor(PDGF), transforming growth factor-beta (TGF-ß), platelet-derived epidermal growth factor (PDGF), platelet-derived angiogenesis factor, insulin-like growth factor 1(IGF1), and platelet factor 4. These factors signal the local mesenchymal and epithelial cells to migrate, divide, and increase collagen and matrix synthesis. Anitua et al in 2001 introduced the concept of PRGF and since then it has been used for a variety of purposes in the field of dentistry and oral implantology for proper wound healing and regeneration of periodontal tissues. This review aims to give a brief idea about the various uses of PRGF and the possibility of utilization in the future taking into consideration many studies that have been done. The main advantage of using PRGF is that it lacks the leukocyte content thus preventing damage to the tissues during healing due to the acid hydrolases and proteases released from the neutrophils. It has been previously used for treating intrabony defects, to increase the implant-bone contact area, for recession coverage etc. In other fields of medicine, it has been used to cure osteoarthritis, to treat chronic ulcers as well. Therefore, PRGF is a very effective blood concentrate with a high concentration of growth factors and its use should be increased in the clinical practice.

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Plasma rich in growth factors (PRGF) in non-surgical periodontal therapy: a randomized clinical trial

Abstract: Adrita PURKAYASTHA (a) Rinkee MOHANTY (a) Rashmita NAYAK (a) Anurag SATPATHY (a) Abhaya Chandra DAS (a) Manoj KUMAR (a) Gatha MOHANTY (a) Sital PANDA (b) Massimo Del FABBRO (c)

Cited by 20 publications

References 33 publications

Management of Endo-perio Lesion by Guided Tissue Regeneration: A Case Report

Management of Endo-perio Lesion by Guided Tissue Regeneration: A Case Report

Periodontal Wound Healing and Tissue Regeneration: A Narrative Review

Role of PRGF (Plasma Rich in Growth Factors) in Periodontal Regeneration

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