Plasma serotonin is a predictor for deterioration of urinary albumin excretion in men with type 2 diabetes mellitus

Fukui, Michiaki; Shiraishi, Emi; Tanaka, Muhei; Senmaru, Takafumi; Sakabe, Kazumi; Harusato, Ichiko; Hasegawa, Goji; Nakamura, Naoto

doi:10.1016/j.metabol.2009.03.009

Cited by 13 publications

(13 citation statements)

References 18 publications

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“…Elevated UAE reflects diffuse endothelial dysfunction and serves as an important marker of diabetic nephropathy [31]. Increased plasma serotonin metabolite 5-HIAA levels are associ- ated with elevated UAE in diabetic patients [8,9]. Our multivariate analyses demonstrate that microalbuminuric patients have higher coefficient of determination (r-squared) of systolic and late diastolic forward flows during the cardiac cycle, total flow volume and resistive index at popliteal artery and eGFR than those of normoalbuminuric patients.…”

Section: Discussionmentioning

confidence: 75%

“…Plasma serotonin concentrations are increased in patients with carotid atherosclerosis [3], angiographically confirmed coronary artery disease [4], coronary angioplasty or stenting [5], lower extremity arterial disease [6], or chronic kidney disease (CKD) [7]. Plasma serotonin metabolite 5-HIAA levels are also elevated and associated with carotid atherosclerosis, arterial stiffness including lower-leg artery and urinary albumin excretion (UAE) in diabetic patients [8,9]. Therefore, plasma 5-HIAA levels can serve as a circulating biomarker for microand macrovascular complications in diabetic patients even though the vasoconstrictor effect of this molecule is extremely low compared to that of serotonin [10].…”

Section: Subjectsmentioning

confidence: 99%

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Increased plasma serotonin metabolite 5-hydroxyindole acetic acid concentrations are associated with impaired systolic and late diastolic forward flows during cardiac cycle and elevated resistive index at popliteal artery and renal insufficiency in type 2 diabetic patients with microalbuminuria

et al. 2016

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Section: Discussionmentioning

confidence: 75%

Section: Subjectsmentioning

confidence: 99%

Increased plasma serotonin metabolite 5-hydroxyindole acetic acid concentrations are associated with impaired systolic and late diastolic forward flows during cardiac cycle and elevated resistive index at popliteal artery and renal insufficiency in type 2 diabetic patients with microalbuminuria

et al. 2016

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“…[14][15][16][17] Furthermore, on the basis of elevated plasma levels of an end product of 5-HT, 5-hydroxyindole-3-acetic acid, plasma 5-HT has been suggested to be a predictor of nephropathy in diabetic patients. 47 Accordingly, it is suggested that agents such as sarpogrelate with 5-HT antagonistic properties may be useful for the treatment of diabetes-induced cardiovascular complications. However, some caution should be exercised in extrapolating the data from this study to clinical situations because changes in cardiac performance with respect to LVDP, þdP/dt, and ÀdP/dt observed in diabetic animals were small.…”

Section: Discussionmentioning

confidence: 99%

Mechanism of Sarpogrelate Action in Improving Cardiac Function in Diabetes

Goyal

Elimban

et al. 2011

J Cardiovasc Pharmacol Ther

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Although sarpogrelate, a 5-HT(2A) receptor antagonist, has been reported to exert beneficial effects in diabetes, the mechanisms of its action are not understood. In this study, diabetes was induced in rats by an injection of streptozotocin (65 mg/kg) and the animals were assessed 7 weeks later. Decreased serum insulin as well as increased serum glucose, cholesterol, and triglyceride levels in diabetic animals were associated with increased blood pressure and heart/body weight ratio. Impaired cardiac performance in diabetic animals was evident by decreased heart rate, left ventricular developed pressure, rate of pressure development, and rate of pressure decay. Treatment of diabetic animals with sarpogrelate (5 mg/kg) or insulin (10 units/kg) daily for 6 weeks attenuated the observed changes in serum insulin, glucose, and lipid levels as well as blood pressure and cardiac function by varying degrees. Protein content for membrane glucose transporters (GLUT-1 and GLUT-4) was depressed in diabetic heart; the observed alteration in GLUT-4 was partially prevented by both sarpogrelate and insulin, whereas that in GLUT-1 was attenuated by sarpogrelate only. Incubation of myoblast cells with sarpogrelate and insulin stimulated glucose uptake; these effects were additive. 5-hydroxytryptamine was found to inhibit glucose-induced insulin release from the pancreas; this effect was prevented by sarpogrelate. These results suggest that sarpogrelate may improve cardiac function in chronic diabetes by promoting the expression of membrane glucose transporters as well as by releasing insulin from the pancreas.

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“…Four studies reported on prediction of the onset of nephropathy in patients with normoalbuminuria [25][26][27][28], two on progression of nephropathy in patients with micro-or macroalbuminuria [29,30] and seven reported biomarkers in combined normo-and microalbuminuric patient cohorts (i.e. onset and progression) and thus do not make a distinction between onset and progression [31][32][33][34][35][36][37]. Another two studies assessed biomarkers in combined normo-and microalbuminuric patient cohorts and report the results for onset and progression of nephropathy separately [38,39].…”

Section: Resultsmentioning

confidence: 99%

“…Stated in all but two [33,37] RCT, randomized controlled trial; STARD, Standards for Reporting of Diagnostic Accuracy.…”

Section: Adjustment Score and Biomarker Validity Scorementioning

confidence: 99%

Validity of biomarkers predicting onset or progression of nephropathy in patients with Type 2 diabetes: a systematic review

et al. 2012

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Novel biomarkers predicting onset or progression of nephropathy in patients with Type 2 diabetes have been recently identified. We performed a systematic review to assess the validity of biomarkers predicting onset or progression of nephropathy in patients with Type 2 diabetes in longitudinal studies. The methodological quality of the studies was scored using Standards for Reporting of Diagnostic Accuracy (STARD) criteria and the independent predictive value of the biomarkers beyond conventional risk factors was scored according to the adjustment for these risk factors. Validity of the biomarkers was determined by summarizing the methodological quality and the adjustment score. We identified 15 studies describing 27 biomarkers. Six studies had sufficient methodological quality. These studies identified 13 valid and significant markers for nephropathy in diabetes: serum interleukin 18, plasma asymmetric dimethylarginine; and urinary ceruloplasmin, immunoglobulin G and transferrin were considered valid markers predicting onset of nephropathy. Plasma asymmetric dimethylarginine, vascular cell adhesion molecule 1, interleukin 6, von Willebrand factor and intercellular cell adhesion molecule 1 were considered valid biomarkers predicting progression of nephropathy. Plasma high-sensitivity C-reactive protein, E-selectin, tissue-type plasminogen activator, von Willebrand factor and triglycerides were considered valid markers predicting onset and progression of nephropathy. Several novel biomarkers for prediction of nephropathy in diabetes have been published, which can potentially be applied in clinical practice and research in future. Because of the heterogeneous quality of biomarker studies in this field, a more rigorous evaluation of these biomarkers and validation in larger trials are advocated.

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Plasma serotonin is a predictor for deterioration of urinary albumin excretion in men with type 2 diabetes mellitus

Cited by 13 publications

References 18 publications

Increased plasma serotonin metabolite 5-hydroxyindole acetic acid concentrations are associated with impaired systolic and late diastolic forward flows during cardiac cycle and elevated resistive index at popliteal artery and renal insufficiency in type 2 diabetic patients with microalbuminuria

Increased plasma serotonin metabolite 5-hydroxyindole acetic acid concentrations are associated with impaired systolic and late diastolic forward flows during cardiac cycle and elevated resistive index at popliteal artery and renal insufficiency in type 2 diabetic patients with microalbuminuria

Mechanism of Sarpogrelate Action in Improving Cardiac Function in Diabetes

Validity of biomarkers predicting onset or progression of nephropathy in patients with Type 2 diabetes: a systematic review

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