Plasma serotonin levels and suicidal behavior in adolescents

Tyano, Samuel; Zalsman, Gil; Ofek, Hadas; Blum, Ilanan; Apter, Alan; Wolovik, Luisa; Sher, Leo; Sommerfeld, Eliane; Harell, Daniella; Weizman, Abraham

doi:10.1016/j.euroneuro.2005.05.005

Cited by 55 publications

(44 citation statements)

References 35 publications

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“…5.2). At a biological level, serotoninergic abnormalities leading to suicidal vulnerability have also been observed among adolescent subjects (Tyano et al 2006). During adolescence, environmental stressors may exacerbate imbalances in the function of limbic and ventral prefrontal areas, leading to suicidal behavior, a risk that may be mediated by genetic factors (Casey et al 2010).…”

Section: Toward a Neurodevelopmental Model Of Suicidal Behaviormentioning

confidence: 99%

Stress and Vulnerability: A Developing Model for Suicidal Risk

López-Castromán

Olié

Courtet

2014

Suicide: Phenomenology and Neurobiology

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A large body of research built over the last few decades examines the interaction between stressful events and vulnerability traits to explain how a person becomes suicidal. This stress-diathesis model has been extremely fruitful to improve our understanding of suicidal behavior, but recent findings suggest that interactions could be more complex than expected. Indeed, environmental insults during pregnancy, childhood, or adolescence induce neurodevelopmental changes that increase the vulnerability for suicidal behavior in later life. In this chapter, we will outline the significance of recent neurodevelopmental findings for the stressvulnerability factors of suicidal behavior. The coherence and applicability of an integrative neurodevelopmental model of suicidal behavior will be discussed in the light of current research concerning genetics, neuroimaging, and neuropsychology, and the new classification systems. IntroductionDespite treatment and prevention advances on major psychiatric disorders, suicidal behavior still constitutes a major public health problem. Research into this behavior has increased exponentially during the last decade, and a complex network of factors, both predisposing and triggering the suicidal acts, is being unraveled. This dynamic network connects mental disorders, life experiences, social and familial interactions, physical illness, and neurobiology into what is known as the suicidal process. However, until a deeper understanding of the relationships between these factors is developed, crucial issues such as yielding an accurate prediction of future suicidal acts or determining the best treatment for suicidal patients remain distant.

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Section: Toward a Neurodevelopmental Model Of Suicidal Behaviormentioning

confidence: 99%

Stress and Vulnerability: A Developing Model for Suicidal Risk

López-Castromán

Olié

Courtet

2014

Suicide: Phenomenology and Neurobiology

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“…Recent examples include the demonstration of abnormally high levels of the endocannabinoid anadamide (Giuffrida et al, 2004) and the endogenous NMDA receptor antagonist kynurenate (Erhardt et al, 2003) in the CSF of first episode paranoid schizophrenics, or high plasma serotonin levels as markers for psychopathology and suicidality (Tyano et al, 2006). Although changes in peripheral markers of brain neurotransmitter concentrations may result from increased burst firing of neurons, these measures per se are not capable of indicating the contribution of phasically active neurons, and thus favor conclusions in terms of steady-state changes in neurotransmitter synthesis and/or extracellular concentrations.…”

Section: Traditional Measures Of Neurotransmitter Release/levels Favomentioning

confidence: 99%

Abnormal Neurotransmitter Release Underlying Behavioral and Cognitive Disorders: Toward Concepts of Dynamic and Function-Specific Dysregulation

Sarter

Bruno

Parikh

2006

Neuropsychopharmacol

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Abnormalities in the regulation of neurotransmitter release and/or abnormal levels of extracellular neurotransmitter concentrations have remained core components of hypotheses on the neuronal foundations of behavioral and cognitive disorders and the symptoms of neuropsychiatric and neurodegenerative disorders. Furthermore, therapeutic drugs for the treatment of these disorders have been developed and categorized largely on the basis of their effects on neurotransmitter release and resulting receptor stimulation. This perspective stresses the theoretical and practical implications of hypotheses that address the dynamic nature of neurotransmitter dysregulation, including the multiple feedback mechanisms regulating synaptic processes, phasic and tonic components of neurotransmission, compartmentalized release, differentiation between dysregulation of basal vs activated release, and abnormal release from neuronal systems recruited by behavioral and cognitive activity. Several examples illustrate that the nature of the neurotransmitter dysregulation in animal models, including the direction of drug effects on neurotransmitter release, depends fundamentally on the state of activity of the neurotransmitter system of interest and on the behavioral and cognitive functions recruiting these systems. Evidence from evolving techniques for the measurement of neurotransmitter release at high spatial and temporal resolution is likely to advance hypotheses describing the pivotal role of neurotransmitter dysfunction in the development of essential symptoms of major neuropsychiatric disorders, and also to refine neuropharmacological mechanisms to serve as targets for new treatment approaches. The significance and usefulness of hypotheses concerning the abnormal regulation of the release of extracellular concentrations of primary messengers depend on the effective integration of emerging concepts describing the dynamic, compartmentalized, and activitydependent characteristics of dysregulated neurotransmitter systems.

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“…For example, Tyano et al (22) found significantly higher peripheral 5-HT among in-patient adolescents compared with controls and, at the same time, a significant association between suicidal behavior and low plasma 5-HT among a subgroup of suicide attempters. In contrast with adult studies (20), Pfeffer (17) could not identify a relationship between suicidal tendencies and the platelet serotonin content among prepubertal inpatients.…”

Section: Platelets Studiesmentioning

confidence: 96%

The role of serotonin in adolescent suicide: theoretical, methodological, and clinical concerns

Picouto

Villar-Cabeza

Braquehais

2015

International Journal of Adolescent Medicine and Health

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Studies on the neurobiology of adolescent suicide should consider the biological specificities of this life stage and of gender differences during this period. Future research designs should also try to integrate findings in the psychological and biological domains. Prospective studies may help understand the process that leads from suicidal ideation to suicide attempts or completed suicides in this population.

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Plasma serotonin levels and suicidal behavior in adolescents

Cited by 55 publications

References 35 publications

Stress and Vulnerability: A Developing Model for Suicidal Risk

Stress and Vulnerability: A Developing Model for Suicidal Risk

Abnormal Neurotransmitter Release Underlying Behavioral and Cognitive Disorders: Toward Concepts of Dynamic and Function-Specific Dysregulation

The role of serotonin in adolescent suicide: theoretical, methodological, and clinical concerns

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