Plasma Taurine, Diabetes Genetic Predisposition, and Changes of Insulin Sensitivity in Response to Weight-Loss Diets

Zheng, Yan; Ceglarek, Uta; Huang, Tao; Wang, Tiange; Heianza, Yoriko; Ma, Wenjie; Bray, George A.; Thiery, Joachim; Sacks, Frank M.; Qi, Lü

doi:10.1210/jc.2016-1760

Cited by 32 publications

(21 citation statements)

References 36 publications

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“…It correlated with triacylglycerols ( r = −0.2, p < 0.001) and increased with antihypertensive and/or lipid-controlling medication, suggesting a role in lipid metabolism. The lower level of 2-hydroxyethanesulfonate among cases supports a proposed link between taurine metabolism disturbance and diabetes [ 34 , 35 ].…”

Section: Discussionmentioning

confidence: 75%

Plasma metabolites associated with type 2 diabetes in a Swedish population: a case–control study nested in a prospective cohort

et al. 2018

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Aims/hypothesis The aims of the present work were to identify plasma metabolites that predict future type 2 diabetes, to investigate the changes in identified metabolites among individuals who later did or did not develop type 2 diabetes over time, and to assess the extent to which inclusion of predictive metabolites could improve risk prediction. Methods We established a nested case-control study within the Swedish prospective population-based Västerbotten Intervention Programme cohort. Using untargeted liquid chromatography-MS metabolomics, we analysed plasma samples from 503 casecontrol pairs at baseline (a median time of 7 years prior to diagnosis) and samples from a subset of 187 case-control pairs at 10 years of follow-up. Discriminative metabolites between cases and controls at baseline were optimally selected using a multivariate data analysis pipeline adapted for large-scale metabolomics. Conditional logistic regression was used to assess associations between discriminative metabolites and future type 2 diabetes, adjusting for several known risk factors. Reproducibility of identified metabolites was estimated by intra-class correlation over the 10 year period among the subset of healthy participants; their systematic changes over time in relation to diagnosis among those who developed type 2 diabetes were investigated using mixed models. Risk prediction performance of models made from different predictors was evaluated using area under the receiver operating characteristic curve, discrimination improvement index and net reclassification index. Results We identified 46 predictive plasma metabolites of type 2 diabetes. Among novel findings, phosphatidylcholines (PCs) containing odd-chain fatty acids (C19:1 and C17:0) and 2-hydroxyethanesulfonate were associated with the likelihood of developing type 2 diabetes; we also confirmed previously identified predictive biomarkers. Identified metabolites strongly correlated with insulin resistance and/or beta cell dysfunction. Of 46 identified metabolites, 26 showed intermediate to high reproducibility among healthy individuals. Moreover, PCs with odd-chain fatty acids, branched-chain amino acids, 3-methyl-2-oxovaleric acid and glutamate changed over time along with disease progression among diabetes cases. Importantly, we found that a combination of five of the most robustly predictive metabolites significantly improved risk prediction if added to models with an a priori defined set of traditional risk factors, but only a marginal improvement was achieved when using models based on optimally selected traditional risk factors. Diabetologia (2018) 61:849-861 https://doi.org/10.1007/s00125-017-4521-y Electronic supplementary material The online version of this article (https://doi.org/10.1007/s00125-017-4521-y) contains peer-reviewed but unedited supplementary material, which is available to authorised users.

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Section: Discussionmentioning

confidence: 75%

Plasma metabolites associated with type 2 diabetes in a Swedish population: a case–control study nested in a prospective cohort

et al. 2018

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“…Plasma and platelet taurine levels are reduced in subjects with type 1 diabetes ( Franconi et al ., 1995 ). Based on 711 overweight, diabetic subjects, plasma taurine levels are related to the decline in insulin sensitivity ( Zheng et al ., 2016 ). In fact, most of the major targets of diabetes (kidney, retina and neurons) undergo hyperglycemic-mediated reductions in taurine content ( Schaffer et al ., 2009 ).…”

Section: Taurine-mediated Protection Against Pathology and Diseasementioning

confidence: 99%

Effects and Mechanisms of Taurine as a Therapeutic Agent

Schaffer

Kim

2018

Biomolecules & Therapeutics

274

207

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Taurine is an abundant, β-amino acid with diverse cytoprotective activity. In some species, taurine is an essential nutrient but in man it is considered a semi-essential nutrient, although cells lacking taurine show major pathology. These findings have spurred interest in the potential use of taurine as a therapeutic agent. The discovery that taurine is an effective therapy against congestive heart failure led to the study of taurine as a therapeutic agent against other disease conditions. Today, taurine has been approved for the treatment of congestive heart failure in Japan and shows promise in the treatment of several other diseases. The present review summarizes studies supporting a role of taurine in the treatment of diseases of muscle, the central nervous system, and the cardiovascular system. In addition, taurine is extremely effective in the treatment of the mitochondrial disease, mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes (MELAS), and offers a new approach for the treatment of metabolic diseases, such as diabetes, and inflammatory diseases, such as arthritis. The review also addresses the functions of taurine (regulation of antioxidation, energy metabolism, gene expression, ER stress, neuromodulation, quality control and calcium homeostasis) underlying these therapeutic actions.

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“…Studies investigating the effect of dietary habits on GDM risk have shown that Western dietary pattern is an important risk factor for GDM . Nutritional transition from traditional to Western dietary pattern (high caloric and low nutrient density) may be associated with the development of metabolic disorders . A systematic review of observational studies demonstrated that the Western‐style dietary pattern is attributed to higher intake of red meat, egg, processed meat, sweets, refined grains, high‐fat dairy products and savoury snacks which is associated with elevated GDM risk.…”

Section: Introductionmentioning

confidence: 99%

“…10,12 Nutritional transition from traditional to Western dietary pattern (high caloric and low nutrient density) may be associated with the development of metabolic disorders. 13 A systematic review of observational studies demonstrated that the Western-style dietary pattern is attributed to higher intake of red meat, egg, processed meat, sweets, refined grains, high-fat dairy products and savoury snacks which is associated with elevated GDM risk. On the contrary, adherence to the Mediterranean-style dietary pattern (characterised by high consumption of fruits, vegetables, legumes, whole grains and fish) is associated with lower GDM risk.…”

Section: Introductionmentioning

confidence: 99%

The relationship between pre‐pregnancy dietary patterns adherence and risk of gestational diabetes mellitus in Iran: A case–control study

Asadi

Shahzeidi

Nadjarzadeh

et al. 2019

Nutrition & Dietetics

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Aim The present study aimed to investigate major dietary patterns and their association with risk of gestational diabetes mellitus (GDM) in Yazd city located in Iran. Methods This case–control designed study was conducted at six healthcare centres. Two hundred and seventy‐eight pregnant women who referred for GDM screening participated. Dietary assessment was carried out by using a 67‐item validated food frequency questionnaire to evaluate dietary history of participants during the last year. Principal component analysis was used to identify major food patterns. Multivariable logistic regression model was employed to identify the association between dietary patterns and risk of GDM. Results Two major dietary patterns were detected. The Western dietary pattern was associated with higher intakes of sugar‐sweetened beverages, refined grain products, fast foods, salty snacks, sweets and biscuit, mayonnaise and saturated oils, while the prudent dietary pattern was associated with higher intakes of fruits, low‐fat dairy, potato, egg, fish, poultry, nuts, organs meat and red meat. Furthermore, prudent dietary pattern was negatively associated with GDM risk (OR = 0.88, 95% CI: 0.44–0.99). However, there was no significant association between adherence of the Western dietary pattern and risk of GDM. Conclusions Pre‐pregnancy adherence of the prudent dietary pattern was significantly associated with reduced risk of GDM.

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Plasma Taurine, Diabetes Genetic Predisposition, and Changes of Insulin Sensitivity in Response to Weight-Loss Diets

Abstract: Our data suggest that blood taurine levels might differentially modulate the effects of diabetes-related genes on improvement of insulin sensitivity among overweight/obese patients on weight-loss diets.

Cited by 32 publications

References 36 publications

Plasma metabolites associated with type 2 diabetes in a Swedish population: a case–control study nested in a prospective cohort

Plasma metabolites associated with type 2 diabetes in a Swedish population: a case–control study nested in a prospective cohort

Effects and Mechanisms of Taurine as a Therapeutic Agent

The relationship between pre‐pregnancy dietary patterns adherence and risk of gestational diabetes mellitus in Iran: A case–control study

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