Plasma Testosterone and Prolactin in the Menstrual Cycle

Epstein, M.T; McNeilly, A. S.; Murray, M. A. F.; Hockaday, T. D. R.

doi:10.1111/j.1365-2265.1975.tb01565.x

Cited by 27 publications

(13 citation statements)

References 19 publications

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“…Some women had an increased nocturnal plasma PRL level at midcycle, but the peak level at this time was not significantly different for the group as a whole. This finding is in agreement with other reports (26)(27)(28)(29) which reported that some, but not all, women have increased plasma PRL levels at midcycle. The small, early evening peak in plasma PRL levels that was evident in most of our subjects has also been observed previously (29,30).…”

Section: Discussionsupporting

confidence: 95%

The Circadian Rhythm of Plasma Melatonin During the Normal Menstrual Cycle and in Amenorrheic Women*

Brzezinski¹,

Lynch²,

Seibel³

et al. 1988

The Journal of Clinical Endocrinology & Metabolism

178

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Plasma melatonin, PRL, and LH levels were measured in samples collected every 2 h for 24 h from 14 normally cycling women during the early follicular, periovulatory, and luteal phases of their menstrual cycles. Plasma melatonin levels also were measured in samples collected at the same interval from 7 patients with hypothalamic amenorrhea. A distinct daily rhythm in plasma melatonin was evident in all subjects, with peaks occurring around 0300 h. Each woman's rhythm was remarkably consistent throughout the menstrual cycle (in terms of the phase, amplitude, and total melatonin secreted). Plasma PRL levels also exhibited daily rhythms which did not change during the menstrual cycle; the nocturnal peak plasma PRL level tended to occur 1-2 h after that for melatonin. Among the amenorrheic women, both daytime and nighttime melatonin levels were significantly higher (P less than 0.005) than in the normal women. Their plasma PRL levels were similar to those in the normal women. We conclude that, as for PRL, the circadian rhythm of melatonin secretion does not change significantly during the normal menstrual cycle. The elevated plasma melatonin levels in women with hypothalamic amenorrhea suggest that the hormone may be involved in the neuroendocrine pathology underlying this disorder.

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Section: Discussionsupporting

confidence: 95%

The Circadian Rhythm of Plasma Melatonin During the Normal Menstrual Cycle and in Amenorrheic Women*

Brzezinski¹,

Lynch²,

Seibel³

et al. 1988

The Journal of Clinical Endocrinology & Metabolism

178

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“…In 1972, Vekemans et al using a radioimmunoassay (3) described a biphasic pattern of serum prolactin concentration during the menstrual cycle: there was a distinct midcycle peak and during the luteal phase the levels fluctuated around an average value significantly higher than during the early follicular phase. Some investigators reported similar changes (4-7), but others did not observe any significant variation in circulating prolactin during the cycle (8)(9)(10)(11)(12)(13). In this study, involving a larger series of cycles we confirmed our previous observations (3).…”

Section: Discussionsupporting

confidence: 94%

“…In women, circulating prolactin has been measured during the menstrual cycle by several investigators. Contradictory data were reported (3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13). The purpose of this study was to Received October 6, 1976.…”

mentioning

confidence: 90%

Serum Prolactin Levels During the Menstrual Cycle

Vekemans

Delvoye

L’Hermite

et al. 1977

The Journal of Clinical Endocrinology & Metabolism

125

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Serum prolactin has been measured in blood samples collected daily during 51 menstrual cycles using an homologous human radioimmunoassay for 17 cycles and an homologous ovine radioimmunoassay for 34 cycles. There was a progressive and significant increase in serum prolactin during the late follicular phase, with a maximal value concomitant to the LH peak. Serum prolactin levels were also significantly higher during the luteal phase than during early follicular phase. In some 70% of the individual cycles, the highest serum prolactin level was found at mid-cycle. Similar patterns were obtained with both radioimmunoassays. However, when using the same laboratory serum standard, the average serum prolactin level calculated for the entire cycle was 1.6 times higher with the homologous ovine assay than with the homologous human assay. The overall pattern of serum prolactin during the menstrual cycle resembles that reported for circulating 17beta-estradiol.

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“…Some investigators have failed to observe any systemic fluctuation on prolactin levels during the cycle (Ehara et al, 1973, McNeilly and Chard 1974, Epstein et al, 1975, while recent reports, referred to an overall pattern of serum prolactin during the menstrual cycle which resembled that for circulating estradiol (Franchimont et al, 1976, Vekemans et al, 1977, Djursing et al, 1981, Minakami et al, 1985 with small differences between the prolactin levels in the follicular and luteal phases.…”

mentioning

confidence: 99%