Plasma Total Homocysteine, Pregnancy Complications, and Adverse Pregnancy Outcomes: The Hordaland Homocysteine Study

Vollset, Stein Emil; Refsum, Helga; Irgens, Lorentz M.; Emblem, Barbro Mork; Tverdal, Aage; Gjessing, Håkon K.; Monsen, Anne Lise Bjørke; Ueland, Per Magne

doi:10.1097/00006254-200010000-00002

Cited by 111 publications

(160 citation statements)

References 35 publications

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“…The present study shows that there was significant hyperhomocysteinemia and deficiency of folic acid and vitamin B 12 patients with preeclampsia. Hyperhomocysteinemia in such preeclamptic patients were found in our study might be due to modulation in homocysteine metabolism, which corroborates with the work of Walker et al [13], Hogg et al [14], Vollset et al [15]. About more than one-half of the cases (54%) had hyperhomocysteinemia in study group of preeclamptic patients in our study.…”

Section: Discussionsupporting

confidence: 93%

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Study of Serum Homocysteine, Folic Acid and Vitamin B12 in Patients with Preeclampsia

2011

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The present study was carried out to evaluate the occurrence of association between homocysteine, folic acid and vitamin B 12 in patients with preeclampsia. Fifty preeclamptic patients from gynecology ward were studied for estimation of serum homocysteine, folic acid and vitamin B 12 over a period of October 2007 to June 2010. Serum homocysteine and folic acid, and vitamin B 12 were determined by means of Immulite 1000 analyzer. The statistical analysis of study group of preeclampsia compared with normotensive control group, showed significant alterations in serum homocysteine, folic acid and vitamin B 12 concentrations in preeclampsia. Inverse association between serum homocysteine and folic acid, and vitamin B 12 levels were observed in preeclampsia. The present study found hyperhomocysteinemia and deficiency of folic acid and vitamin B 12 along with increased blood pressure as a risk factor for cardiovascular disease (CVD) in preeclampsia.

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Section: Discussionsupporting

confidence: 93%

“…Metabolism in the kidney is the major route by which homocysteine is cleared from plasma and this route of elimination may be affected by preeclamptic changes in the kidney [16]. Several studies have demonstrated serum concentrations of homocysteine increases in preeclampsia [13][14][15]. These studies support our results.…”

Section: Discussionsupporting

confidence: 90%

Study of Serum Homocysteine, Folic Acid and Vitamin B12 in Patients with Preeclampsia

2011

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“…Total homocysteine (tHcy) has been associated with increased risk of several diseases in the general population, such as cardiovascular disease (CVD), adverse pregnancy outcomes, cancer, osteoporosis and cognitive decline in the elderly (Boushey et al, 1995;Vollset et al, 2000;Duthie et al, 2002;Ford et al, 2002;Meleady et al, 2003;McLean et al, 2004). It is not clear whether these associations are causal.…”

Section: Introductionmentioning

confidence: 99%

Changes in lifestyle, biological risk factors and total homocysteine in relation to MTHFR C677T genotype: a 5-year follow-up study

Husemoen¹,

Linneberg²,

Fenger

et al. 2009

Eur J Clin Nutr

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Background/Objectives: Total homocysteine (tHcy) has been associated with increased risk of several diseases in the general population. It is not clear whether these associations are causal. A less healthy lifestyle as well as a less favorable biological risk factor profile have been related to increased tHcy in cross-sectional studies. In addition, the methylenetetrahydrofolate reductase (MTHFR) C677T gene variant is an important determinant of elevated tHcy. The main objective of the study was to examine the effect of changes in biological risk factors and lifestyle on tHcy in relation to MTHFR C677T genotype. Subjects/Methods: The study is a population-based study including 1805 men and women aged 30-60 years participating in a health examination at baseline (1999)(2000)(2001) and at a 5-year follow-up examination. Results: Changes in tHcy were not associated with changes in dietary habits, physical activity, smoking status, coffee, tea, total alcohol or wine consumption. An inverse relationship was observed between changes in tHcy and changes in the intake of beer in TT individuals but not in CC/CT individuals (P interaction ¼ 0.01). In addition, changes in tHcy were positively associated with changes in several biological risk factors, such as waist circumference, diastolic blood pressure, total cholesterol and LDL cholesterol (Po0.01). The association between waist circumference and MTHFR genotype seemed stronger in TT individuals than in CC/CT individuals (P interaction ¼ 0.03). Conclusions: tHcy was not influenced by lifestyle changes except for the inverse association between beer consumption and tHcy observed in TT individuals. This suggests that tHcy is not a mediator in the causal pathway between lifestyle and lifestylerelated diseases such as cardiovascular disease in accordance with results of recent randomized trials. However, tHcy was related to changes in several biological risk factors, suggesting that tHcy may be a good predictor or marker of disease.

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“…As to the possible relationship between serum folate levels and preterm delivery, a series of previous reports have suggested that a low serum folate level during pregnancy increases the risk of premature delivery [14,17,18]. The total homocysteine (tHcy) level measured in serum can be a marker of folate status, suggesting an inverse relationship between serum folate and total homocysteine levels [19].…”

Section: Commentmentioning

confidence: 99%

First-trimester serum folate levels and subsequent risk of abortion and preterm birth among Japanese women with singleton pregnancies

Yamada

Morikawa

Yamada

et al. 2012

Arch Gynecol Obstet

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Objectives: To determine whether a low serum folate level during the first trimester predicts subsequent late abortion, preterm birth, or fetal growth restriction (FGR). Study design:A prospective cohort study involving 5,075 women whose serum folate levels were measured during the first trimester. The participants were informed of their serum folate levels. Results:The pregnancy duration, birthweight, rate of late abortion/preterm birth, and the rate of FGR did not differ significantly among four groups classified according to folate status. The mean serum folate levels did not differ among quartiles classified according to the gestational week at the time of delivery. Nineteen of the 20 women with folate deficiency gave birth at term to infants with a birthweight of 3,132 ± 321 g; only one infant had FGR. Conclusion:Low serum folate levels during the first trimester were not associated with the risk of late abortion, preterm birth, or FGR.

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Plasma Total Homocysteine, Pregnancy Complications, and Adverse Pregnancy Outcomes: The Hordaland Homocysteine Study

Cited by 111 publications

References 35 publications

Study of Serum Homocysteine, Folic Acid and Vitamin B12 in Patients with Preeclampsia

Study of Serum Homocysteine, Folic Acid and Vitamin B12 in Patients with Preeclampsia

Changes in lifestyle, biological risk factors and total homocysteine in relation to MTHFR C677T genotype: a 5-year follow-up study

First-trimester serum folate levels and subsequent risk of abortion and preterm birth among Japanese women with singleton pregnancies

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