Plasma vasopressin in ethanol intoxication and hangover

Linkola, Jaakko; Ylikahri, Reino; Fyhquist, F; Wallenius, Marja

doi:10.1111/j.1748-1716.1978.tb06265.x

Cited by 92 publications

(52 citation statements)

References 24 publications

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“…Several socio-economic factors for each prefecture were used in a stepwise multiple regression analysis. These factors were, the annual income per capita, the number of men per 100,000 who are receiving public aid, the number of tatamis (a Japanese traditional floor unit) per household, the unemployment rate per 100,000 men, the unmarried rate per 100 men aged [35][36][37][38][39][40][41][42][43][44][45][46][47][48][49] Age-adjusted stroke mortalities for all ages and for the middle-aged by sex, and the male:female ratio of age-adjusted stroke mortality for the middle-aged and all ages were used as dependent variables, while alcohol consumption, salt intake and socio-economic factors were used as independent variables in a stepwise multiple regression analysis. The same independent variables were used for the stepwise multiple regres- Table 1 shows the mean and standard deviations of the variables used in this study.…”

Section: Statistics For 46 Prefectures Excluding Okinawa Inmentioning

confidence: 99%

Regional differences in stroke mortality and alcohol consumption in Japan.

Ueshima¹,

Ohsaka²,

Asakura³

1986

Stroke

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SUMMARYThe relationship between alcohol consumption and stroke mortality in 1975 in 46 prefectures of Japan was investigated. This was done by adjusting salt intake and several socio-economic factors, i.e., the annual per capita income, the number of persons who received public aid, the number of tatamis (a Japanese traditional floor unit) per household, the unemployment rate, and the unmarried or divorce rate, using a stepwise multiple regression analysis. As dependent variables, the sex-specific and age-adjusted mortality for the middle-aged (35-59 years) and for all ages due to stroke were used. For men, alcohol consumption was significantly related to age-adjusted stroke mortalities for the middle-aged and for all ages independent of salt intake and several socio-economic factors. Alcohol consumption was more strongly related to age-adjusted stroke mortality for the middle-aged than for all ages. For women alcohol was weakly correlated with the stroke mortality of the middle-aged. Salt intake was significantly correlated with stroke mortality for women but not for men. Furthermore, the male: female ratios of the age-adjusted stroke mortality for the middle aged and for all ages were analyzed as well, because alcohol is mostly consumed by men in Japan, and it was expected that the sex ratios would be well correlated to alcohol consumption. The results were as expected. Therefore, it was suggested that the regional difference in stroke mortality in Japan may be explained in part by that of alcohol consumption. Stroke Vol 17, No 1, 1986STROKE has been one of the leading causes of death in Japan. 1 Hypertension is a major risk factor for stroke.2 ' 8 Mortality, the incidence of stroke, and the prevalence of hypertension have been higher in the northeastern than in the southwestern part of Japan. These areas with high stroke mortality and high prevalence of hypertension correspond to high salt intake.2 -9 "" However, alcohol intake is higher in the northeastern part of the main island (Honshu) of Japan, especially in Akita Prefecture, than in any other area. ' 2 It is well documented not only by cross-sectional epidemiological studies but also by follow-up studies that moderate or heavy level of alcohol drinking is related to hypertension.13 " 16 Furthermore, several animal and epidemiological studies suggest that alcohol is a risk factor for stroke independent of hypertension.6 -8 l7~22Therefore, whether or not the regional difference in stroke mortality across 46 prefectures is related to alcohol consumption, and independent of salt and several socio-economic factors in Japan, was analyzed by a stepwise multiple regression analysis. , excluding Okinawa, in 1975 were used to analyze the relationship between stroke mortality and alcohol consumption. Age-specific stroke mortality data by prefecture and sex were available in the Special Report of Vital Statistics in Japan, 1975. Materials and MethodsStatistics for 46 prefecturesM The age-adjusted stroke mortalities for all ages by sex were calculated using the na...

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Section: Statistics For 46 Prefectures Excluding Okinawa Inmentioning

confidence: 99%

Regional differences in stroke mortality and alcohol consumption in Japan.

Ueshima¹,

Ohsaka²,

Asakura³

1986

Stroke

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“…It has been seen that both magnesium and calcium levels were also found to be affected with age since they got further diminished as the age increases. Age advances alcohol-related hypomagnesemia which could be due to the cumulative effect of multiple factors such as dietary deficiency, reduced intestinal absorption, and increased sensitivity to alcohol-related toxicity [10,11].…”

Section: Resultsmentioning

confidence: 99%

Study of Electrolytes and Liver Function Tests in Chronic Alcoholism

Gill

Kataria

Singh³

et al. 2018

Asian J Pharm Clin Res

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Objective: Alcohol abuse is considered one of the major health issue in India, which can impair the electrolyte balance in chronic patient of alcoholism. In the present study, investigation has been conducted to estimate the levels of calcium, magnesium, SGOT, SGPT, total protein and urea in the chronic alcoholic patients and their comparison was determined with normal healthy controls. Methods:A total of 50 male alcoholics consuming variable amount of alcohol from more than past 5 years in the age frame of 30-70 years were taken. Equal number of age-matched normal healthy individuals without the family history of any disease served as controls. Levels of magnesium (Mg), calcium (Ca), and other biochemicals, namely urea and total protein, transaminases, namely serum glutamate oxaloacetate transaminase and serum glutamate pyruvic transaminase were estimated colorimetrically in all the subjects consuming variable amount of alcohol.Results: Alcoholics were found to have lower magnesium, calcium, and total protein levels as compared to non-alcoholics, whereas transaminases were higher in alcoholics, predicting hepatocytes injury. Catalytic activity of alcohol dehydrogenase produced highly reactive acetaldehyde forming adducts with membrane proteins, leading to organ damage. Alcohol disturbed the electrolytes balance produced hypomagnesia and hypocalcemia and severely affected liver function tests. Conclusion:Magnesium levels and other related parameters could be considered as diagnostic predictors of alcohol-related toxicity. Age advances the alcohol-related health consequences, and this could be due to the cumulative effect of reduced intestinal absorption, dietary deficiencies, and alcohol toxicity.

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“…This phenomenon seemed to be not derived from the degeneration of the HHC by the higher concentration of ethanol, because the tissue sample still responded sensitively to the high K+ concentration after ethanol was removed from the medium. A high concentration of plasma AVP was observed occasionally in patients with acute alcohol intoxication and hangover (Linkola et al, 1978). Furthermore, central pontine myelinolysis observed on alcohol withdrawal is thought to be derived from rapid correction of severe hyponatremia with a saline of high osmolality (Victor and Laureno, 1978).…”

Section: Discussionmentioning

confidence: 99%

Effect of ethanol and acetaldehyde on the release of arginine-vasopressin and oxytocin from the isolated hypothalamo-hypophyseal system of rats.

et al. 1985

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Effects of ethanol and acetaldehyde on the release of arginine-vasopressin (AVP) and oxytocin (OXT) were examined using a superfusion system of the isolated hypothalamo-hypophyseal complex of rats. The release of both hormones was significantly suppressed by exposing the tissue samples to Eagle MEM medium containing 1.75 and 2.5% ethanol (the maximal suppression: AVP, 30% and 70%; OXT, 30% and 70%, respectively). However, perfusion with medium containing 3.75 and 5.0% ethanol enhanced the release of OXT during exposure to ethanol (the maximal increase, 1,000%) and the release of AVP was increased markedly just after exposure to ethanol was stopped (the maximal increase, 800%). Perfusion with medium containing 50, 100 and 250 microM acetaldehyde did not affect the release.

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Plasma vasopressin in ethanol intoxication and hangover

Cited by 92 publications

References 24 publications

Regional differences in stroke mortality and alcohol consumption in Japan.

Regional differences in stroke mortality and alcohol consumption in Japan.

Study of Electrolytes and Liver Function Tests in Chronic Alcoholism

Effect of ethanol and acetaldehyde on the release of arginine-vasopressin and oxytocin from the isolated hypothalamo-hypophyseal system of rats.

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