Plasma viscosity and mean platelet volume in patients undergoing coronary angiography

Abstract

Background: Markers of platelet activation and haemorrheological indices have been demonstrated to play a role in the pathophysiology of atherosclerosis and cardiovascular events. In this study, we aimed at investigate the association between plasma viscosity and platelet indices in patients undergoing coronary angiography.Materials and methods: Three hundred and eighty four consecutive patients scheduled to undergo coronary angiography were included in the study. Prior to coronary angiography, blood samples were withdrawn to determine routine biochemical markers, blood cell analyses and viscosity measurements. According to the results of coronary angiography, patients were classified either in a subgroup with coronary artery disease (CAD; 1 or more stenoses >50%) or normal coronary arteries (NCA; no stenoses or <50%).Results: There was a statistically significant correlation between plasma viscosity and mean platelet volume levels in all patients undergoing coronary angiography (r = 0.199, p < 0.001). Additionally, when correlation analysis was performed within each group, plasma viscosity significantly correlated with MPV both in patients with CAD (r = 0.18, p = 0.004) and in patients with NCAs (r = 0.272, p = 0.002). Linear regression analysis revealed that plasma viscosity was positively associated with MPV while platelet number was inversely but significantly associated with MPV.Conclusion: We have shown for the first time that MPV correlates with plasma viscosity in patients undergoing coronary angiography, suggesting a relation with plasma proteins and activation of circulating platelets or peripheral consumption of platelets. To evaluate this relation further controlled studies also in patients with acute coronary syndromes are warranted.

Endothelial function and hemorheological parameters modulate coronary blood flow in patients without significant coronary artery disease

“…Importantly, recent studies have reported that increased MPV is associated with increased blood viscosity, an observation that is consistent with our findings [28]. We provide the first evidence of a linear relationship between MPV and TIMIfc across a large spectrum of patients.…”

“…Previous studies have shown an increased viscosity in patients with coronary slow flow at angiography [8], and the existence of a strong correlation between blood viscosity and MPV [28]. In our dataset, hematocrit was strongly associated with TIMIfc and was independent of endothelial function and platelet parameters across a wide range of TIMIfc.…”

Relation between platelet indices and branch retinal vein occlusion in hypertensive patients

“…Thrombosis may develop due to endothelial injury, abnormal fibrinolysis, procoagulant activation and platelet abnormalities. [78910] Abnormal platelet aggregability and in vivo platelet function has been reported, suggesting that platelet aggregation might be an important sequel to endothelial swelling, thus leading to the occlusion. [13] Robinson et al ., showed that there is a link between platelet activation and endothelium-dependent vasomotor dysfunction.…”

“…Studies related to the platelets in RVO pathogenesis also reported increased platelet activation and aggregation,[78910] suggesting an eventual alteration with MPV. Thrombosis, indeed, may bear the crucial role for RVO.…”

Branch retinal vein occlusion associated with platelet activation

“…Branch retinal vein occlusion is a common cause of retinal vascular disorder and is said to be the second most common disease after diabetic retinopathy (11). Major pathogenetic factors confined to the pathogenesis of BRVO are abnormal hematological parameters, degenerative changes of the retinal vessel wall, and compression of the retinal vein at the AV crossing (12). Although multiple hematological parameters were discussed in the pathogenesis of BRVO, the role of coagulation parameters remains unclear.…”