Plasma Vitamin E and Coenzyme Q10 Are Not Associated with a Lower Risk of Acute Myocardial Infarction in Singapore Chinese Adults,

Abstract

Vitamin E and coenzyme Q10 (CoQ10) have antioxidant effects that may benefit cardiovascular health. Meta-analyses of randomized controlled trials have not shown a protective effect of supplementation with the vitamin E isomer α-tocopherol on the risk of acute myocardial infarction (AMI), but data on other isomers and CoQ10 are limited. Our objective was to examine the association of the plasma concentrations of vitamin E isomers (α-, γ-, and δ-tocopherol and α-, γ-, and δ-tocotrienol) and CoQ10 (ubiquinol and ubiquinone) with the incidence of AMI. We conducted a nested case-control study with 233 cases of incident AMI and 466 matched controls selected from the Singapore Chinese Health Study, aged 45-74 y at the time of recruitment and free of cardiovascular disease at the time of blood collection. We used conditional logistic regression to examine the association between vitamin E and CoQ10 and the risk of AMI adjusted for other risk factors. In the basic model, higher δ-tocopherol and ubiquinone concentrations were significantly associated with a higher risk of AMI, whereas there were no significant associations for the other vitamin E and CoQ10 isomers. After adjusting for lifestyle and other risk factors, only the association between δ-tocopherol and AMI risk remained significant [OR = 3.09 (95% CI: 1.53, 6.25) highest vs. lowest quintile; P-trend = 0.028]. We did not observe an inverse association between plasma concentrations of vitamin E isomers or CoQ10 and risk of AMI in Singapore Chinese. In contrast, plasma δ-tocopherol concentrations were associated with a higher risk of AMI. Our findings do not support a role of higher vitamin E or CoQ10 intakes in the prevention of AMI.

The Alternative Healthy Eating Index Is Associated with a Lower Risk of Fatal and Nonfatal Acute Myocardial Infarction in a Chinese Adult Population

“…The fatal AMI cases were identified through the Singapore Registry of Births and Deaths [1993-2010; International Classification of Diseases (ICD) 9 codes 410-414]. Further details on the identification of cases have been previously described (22,23). A total of 760 incident cases of fatal (ICD-9 codes 410-414) and nonfatal (ICD-9 code 410) AMI were identified.…”

Functional benefits of PLGA particulates carrying VEGF and CoQ10 in an animal of myocardial ischemia

“…There is compelling evidence that CoQ10 is an independent predictor of mortality in chronic heart failure (Molyneux et al, 2008), while a recent study suggests the plasma concentrations of CoQ10 is not associated with lower risk of AMI (Naidoo et al, 2012).…”

Coenzyme Q10 consumption promotes ABCG1‐mediated macrophage cholesterol efflux: A randomized, double‐blind, placebo‐controlled, cross‐over study in healthy volunteers

“…Although several groups have reported an association between blood CoQ10 concentration and lower risk of CVD, others have reported no relationship [32,33]. Several factors, such as small sample size and large intraindividual biological variability, may be considered to interpret the controversial association between blood CoQ10 concentration and atherosclerotic CVD events.…”