Plasma vitamin E, apolipoprotein B and HDL-cholesterol in middle-aged men from Southern Italy

Rubba, P.; Mancini, Mario; Fidanza, F; Leccia, G.; Riemersma, Rudolph A.; Gey, K. F.

doi:10.1016/0021-9150(89)90005-1

Cited by 7 publications

(3 citation statements)

References 14 publications

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“…(47) In the present MR analysis, our results also showed that elevated circulating vitamin E levels caused an increase in LDL, TC, and TG, but a decrease in HDL, implying an adverse effect of circulating vitamin E on cardiometabolic diseases. Previous observations had unveiled the association between vitamin E intake and cardiometabolic traits, (34,35,(48)(49)(50) which were consistent with our results. For instance, Ganini and Mason (48) found that vitamin E intake did not protect LDL from the protein radical formation, thus failing to be a cardiometabolic protective agent for humans.…”

Section: Discussionsupporting

confidence: 93%

“…For instance, Ganini and Mason (48) found that vitamin E intake did not protect LDL from the protein radical formation, thus failing to be a cardiometabolic protective agent for humans. Additionally, it had been identified that elevated vitamin E levels raised normal plasma triglycerides levels in conditions of hypercholesterolemia (50) and reduced HDL levels in hypertriglyceridemic patients. (51) Of note, several perspective studies have provided evidence to support that LDL is rendered atherogenic by oxidative modifications that allow it to accumulate, which is an important step in the development and progression of atherosclerosis.…”

Section: Discussionmentioning

confidence: 99%

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Circulating vitamin E and cardiometabolic measures: a Mendelian randomization analysis

Fan

Huang

Kong

et al. 2019

J. Clin. Biochem. Nutr.

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Although a large body of literature reported that high intake of vitamin E played a possible role in reducing risk of cardiometabolic diseases, conflicting results were also found in some observational studies due to confounding factors. Hence, we used a Mendelian randomization study as an alternative way to examine the causality between circulating vitamin E and cardiometabolic diseases. Summary level data were extracted from consortia and three single nucleotide polymorphisms were used as instrumental variables. Our study showed that a one SD increase in circulating vitamin E levels was causally associated with an increased risk of coronary artery disease [odds ratio (OR) 3.16 (95%CI 1.74, 5.73); p = 1.91 × 10-3 ] at the Bonferroni adjusted level of significance (p<0.005). Moreover, a one SD increase in circulating vitamin E levels was associated with a 0.572 SD increase in low density lipo protein cholesterol (mg/dl), a 0.693 SD increase in total cholesterol (mg/dl), and a 1.45 SD increase in triglyceride (mg/dl), but a 0.502 SD decrease in high density lipoprotein cholesterol (mg/dl) at the Bonferroni adjusted level of significance (p<0.0028). Our findings indicated that genetically elevated vitamin E was associated with increased risk of coronary artery disease, suggesting an adverse causality between circulating vitamin E and coronary artery disease.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Circulating vitamin E and cardiometabolic measures: a Mendelian randomization analysis

Fan

Huang

Kong

et al. 2019

J. Clin. Biochem. Nutr.

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show abstract

“…This is especially important because plasma concentrations of vitamin E are highly infl uenced by both LDL and VLDL levels in both hyperlipidemic patients and in the general population. One way of dealing with this strong association is to examine the ratio of vitamin E to total cholesterol [167] . However, this typically has not been done.…”

Section: Discussionmentioning

confidence: 99%

Hematologic Risk Factors of Vascular Disease and Their Relation to Dementia

Mielke

Zandi

2006

Dement Geriatr Cogn Disord

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Multiple studies have implicated vascular-related conditions as risk factors for dementia. Clarification of these factors in dementia is important because most are modifiable, and may serve as the basis for preventive strategies. Several hematologic factors are associated with vascular diseases, but their relation to dementia is unclear. This review examines biological and epidemiological evidence concerning the role of these hematologic factors in dementia, and dementia subtypes. Reviewed factors include homocysteine, cholesterol, fatty acids, antioxidants, and C-reactive protein. The vast majority of studies reviewed are cross-sectional. Longitudinal studies with serial hematologic measures are needed to clarify the relationship between these factors and dementia over the lifespan. A necessary step is to examine multiple hematologic factors simultaneously, rather than in isolation, to determine how these factors are interrelated.

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Effects of Tocotrienol-Rich Vitamin E on Patients with Peripheral Vascular Disease

Teoh¹,

Chong²,

Jamaludin³

1992

Lipid-Soluble Antioxidants: Biochemistry and Clinical Applications

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Plasma vitamin E, apolipoprotein B and HDL-cholesterol in middle-aged men from Southern Italy

Cited by 7 publications

References 14 publications

Circulating vitamin E and cardiometabolic measures: a Mendelian randomization analysis

Circulating vitamin E and cardiometabolic measures: a Mendelian randomization analysis

Hematologic Risk Factors of Vascular Disease and Their Relation to Dementia

Effects of Tocotrienol-Rich Vitamin E on Patients with Peripheral Vascular Disease

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