Plasmablastic lymphoma: An update

Bailly, Justine; Jenkins, Nicholas; Chetty,; Mohamed, Zainab; Verburgh, Estelle; Opie, Jessica

doi:10.1111/ijlh.13863

Cited by 30 publications

(18 citation statements)

References 64 publications

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“…This corrigendum corrects the article by Bailly et al 1 The error was published on page 58, where the article reads:…”

mentioning

confidence: 77%

Plasmablastic lymphoma: An update

2022

Int J Lab Hematology

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“…This corrigendum corrects the article by Bailly et al 1 The error was published on page 58, where the article reads:…”

mentioning

confidence: 77%

Plasmablastic lymphoma: An update

2022

Int J Lab Hematology

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“…Despite the similarities in presenting symptoms and tumor cell morphology between PBL and other hematologic malignancies, PBL can be distinguished based on its distinct immunophenotypic footprint. The typical immunophenotype in PBL includes positivity for CD38, CD138, MUM1/IRF4, and EBER accompanied by a high Ki-67 proliferation index [ 1 , 5 , 15 ]. As demonstrated by our patient’s case, even an atypical presentation of an uncommon pathology can be readily identified by tissue sampling followed by careful analysis of cell morphology and immunophenotype in conjunction with an experienced pathologist.…”

Section: Discussionmentioning

confidence: 99%

An Atypical Presentation of an Uncommon Malignancy: Plasmablastic Lymphoma Presenting As Recurrent Scrotal Abscesses

Wiemer¹,

Quan²,

Omman³

2023

Cureus

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Plasmablastic lymphoma (PBL) is a rare and extremely diagnostically challenging entity. We report a unique case of PBL in an adult male with a history of recurrent scrotal abscesses who presented with progressively worsening scrotal pain, swelling, and drainage. Pelvic CT demonstrated a large scrotal abscess with external draining tracts with foci of air. Surgical debridement revealed necrotic tissue throughout the abscess cavity, abscess wall, and scrotal skin. Immunohistochemical analysis of the scrotal skin specimen uncovered diffuse proliferation of plasmacytoid cells with immunoblastic features that stained positive for CD138, CD38, IRF4/MUM1, CD45, lambda restriction, and Epstein-Barr encoded RNA in situ hybridization (EBER-ISH) with high Ki-67 proliferation index greater than 90%. Taken together, these findings confirmed a diagnosis of PBL. Treatment with six cycles of infusional etoposide, prednisolone, vincristine, cyclophosphamide, and hydroxydaunorubicin (EPOCH-like regimen) was administered with subsequent positron emission tomography (PET)/CT confirmation of complete response. There was no clinical evidence of lymphoma recurrence at the time of follow-up six months later. Our case exemplifies the growing diversity of ways in which PBL may manifest and underscores the importance of a clinician’s familiarity with this entity and its well-defined risk factor of immunosuppression.

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“…Most PBL patients present at advanced stage with frequent BM involvement [ 78 , 79 ]. PBL carries a poor prognosis with a median progression-free survival of 6 months; however, it does respond to chemotherapy and involved field radiotherapy, enabling many to achieve temporary remission [ 80 , 81 ]. CHOP remains a commonly used chemotherapy regimen, particularly in resource-constrained settings [ 81 ].…”

Section: Malignanciesmentioning

confidence: 99%

Hematological Complications of Human Immunodeficiency Virus (HIV) Infection: An Update From an HIV-Endemic Setting

Opie,

Verburgh,

Bailly

et al. 2024

Open Forum Infectious Diseases

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Medical professionals, particularly in regions with a high burden of human immunodeficiency virus (HIV), should be alert to the hematological complications of HIV which may include cytopenias, malignancy and coagulation disturbances. Patients may present with these conditions as the first manifestation of HIV infection. Hematological abnormalities are often multifactorial with opportunistic infection, drugs, malignancy, and HIV infection itself contributing to the clinical presentation, and the diagnosis should consider all these factors. Life-threatening hematological complications requiring urgent diagnosis and management include thrombotic thrombocytopenic purpura, superior mediastinal syndrome, spinal cord compression and tumour lysis syndrome due to aggressive lymphoma. Antiretroviral therapy is the therapeutic backbone, including for patients with advanced disease, in addition to specific therapy for the complication. This article reviews the impact of HIV on the hematological system and provides a clinical and diagnostic approach, including the role of a bone marrow biopsy, focusing on perspectives from sub-Saharan Africa.

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Plasmablastic lymphoma: An update

Cited by 30 publications

References 64 publications

Plasmablastic lymphoma: An update

Plasmablastic lymphoma: An update

An Atypical Presentation of an Uncommon Malignancy: Plasmablastic Lymphoma Presenting As Recurrent Scrotal Abscesses

Hematological Complications of Human Immunodeficiency Virus (HIV) Infection: An Update From an HIV-Endemic Setting

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