Plasmacytoid Myoepithelioma of the Palate: Case Report

Abstract

Myoepitheliomas are extremely rare benign neoplasms of salivary glands. They represent 1-1.5% of all salivary gland tumors. They occur, principally, in the parotid gland and infrequently in minor salivary glands. There are distinct histological and immunohistochemical characteristics of the tumor which aid in the diagnosis. Myoepithelioma of the palate is uncommon and only a limited number of cases has been reported in the English literature. Herein, a case of plasmacytoid type of myoepithelioma of the palate in an adult female is presented along with review of the literature.

Myoepithlioma of Soft Palate: a case report

“…Particularly, it seems that spindle-cell and clear-cell type occur more often in parotid glands, while plasmacytoid type occurs more often intraorally, especially in the minor salivary glands of the palate which was also seen in our case. 9 Despite the fact that this tumor demonstrate intense hyalinization of the connective tissue as well as foci of myxoid changes, there is no evidence of chondroid or osteoid tissue which is similar to our study. 3 Conflicting results have been obtained on immunostains of myoepitheliomas.…”

“…6,10 Ki-67 labeling index of more than 10% in ME is highly suggestive of malignant biological behavior. 1,9 Ki -67 labeling index in the present case was only 1% ruling out possibility of myoepithelial carcinoma. Hence, based on histopathological evaluation and immunohistochemical confirmation of the myoepithelial origin of the tumor cell diagnosis of myoepithelima was given.…”

Plasmacytoid myoepithelioma: Diagnostic algorithm and a tailored therapeutic protocol for a geriatric individual

“…The clinical appearance varies from being a small submucosal nodule to ulceroproliferative growth without the involvement of regional lymph nodes. Most of the cases described so far have ranged from 0.8 to 6 cm [2]. To the best of our knowledge, the case described here is the largest till date in a geriatric patient.…”

“…In the present case a lower Ki-67 LI of 5% aided in ruling out malignancy. Even though myoepithelial neoplastic cells show variable immunoreactivity, cytokeratins, vimentin, S100 protein and GFAP are positive and considered as reliable markers of PM [1,2,4]. Positive immunoreactivity for pan-cytokeratin in conjunction with one or more myoepithelial markers may be required for corroboration of the diagnosis [1].…”

“…The incidence of myoepithelioma is 1.5% of all salivary gland neoplasms and accounts for 2.2% and 5.7% of all benign major and minor salivary gland tumours respectively [1]. It usually occurs in the 4th-5th decade of life with palate being the principal site involved, accounting for 21% of all cases and 93% of intraoral cases of myoepithelioma [2].…”