Plasmalogen-selective phospholipase A2 and its involvement in Alzheimer's disease

Farooqui, Akhlaq A.; Horrocks, Lloyd A.

doi:10.1042/bst0260243

Cited by 27 publications

(22 citation statements)

References 8 publications

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“…Third, whereas different subclasses of PC are hydrolyzed in LOAD, the biggest decrease in any GP species is the greater than 75% decrease in PE ( m/z 780) that corresponds to PE(40p:4/40e:5). A plasmalogenspecifi c PLA 2 is implicated in AD pathology and may be responsible for the depletion of brain plasmalogen in AD ( 20 ). These data show more specifi city in the degradation of PE plasmalogen but not PC and PS species in LOAD compared with CH.…”

Section: Pla 2 Activity Contributed To Loadsupporting

confidence: 56%

“…Second, several GP substrates are hydrolyzed, suggesting nonsubstrate specifi city or involvement of different PLA 2 isoforms in LOAD. Studies support the role of different PLA 2 isoforms in AD ( 20,23,41 ). Third, whereas different subclasses of PC are hydrolyzed in LOAD, the biggest decrease in any GP species is the greater than 75% decrease in PE ( m/z 780) that corresponds to PE(40p:4/40e:5).…”

Section: Pla 2 Activity Contributed To Loadmentioning

confidence: 99%

“…GP hydrolysis generates signaling and inflammatory molecules, oxidized PC is associated with ApoA1, amyloidosis, and phospholipase A 2 (PLA 2 ) activation (20)(21)(22)(23). Thus, measurement of GP composition and PLA 2 activity in cerebrospinal fl uid (CSF) may elucidate potential mechanisms of AD progression.…”

Section: Csf Fractionation and Gp Extractionmentioning

confidence: 99%

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Alterations in cerebrospinal fluid glycerophospholipids and phospholipase A2 activity in Alzheimer's disease

Fonteh

Chiang

Cipolla

et al. 2013

Journal of Lipid Research

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Section: Pla 2 Activity Contributed To Loadsupporting

confidence: 56%

Section: Pla 2 Activity Contributed To Loadmentioning

confidence: 99%

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Alterations in cerebrospinal fluid glycerophospholipids and phospholipase A2 activity in Alzheimer's disease

Fonteh

Chiang

Cipolla

et al. 2013

Journal of Lipid Research

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“…The physiological function of plasmalogen is not known, though recent studies suggest that plasmalogen in the phosphatidylethanolamine in the brain plays the role of an antioxidant by lowering the ability of cholesterol to be oxidized in phospholipid bilayers as well as in the entire membranes (25,26). In addition, it has been reported that the plasmalogen concentration in the plasma is significantly reduced by aging and hyperlipidemia (27), whereas the ethanolamine plasmalogen levels in the serum were lower in dementia patients with Alzheimer's disease (28,29). Based on these studies, it is concluded that plasmalogen has important functions in vivo, especially the antioxidant function for maintaining and improving brain functions.…”

Section: Discussionmentioning

confidence: 99%

Effects of Dietary Sialic Acid in n-3 Fatty Acid-Deficient Dams during Pregnancy and Lactation on the Learning Abilities of Their Pups after Weaning

Hiratsuka

Honma

Saitoh

et al. 2013

J Nutr Sci Vitaminol

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SummaryThe effects of dietary sialic acid in dams on the learning abilities of their pups after weaning were investigated using rats deficient in n-3 fatty acids. Nine-week-old female Wistar rats were fed an n-3 fatty acid-deficient diet for 3 wk and were mated at 12 wk of age. During pregnancy and lactation, the female rats were fed the n-3 fatty acid-deficient diet, and were given water or water containing 1% N-acetylneuraminic acid (NANA) ad libitum. After weaning, the learning abilities of the pups were evaluated using a novel object recognition test. The recognition index of pups nursed by dams fed on water containing 1% NANA (NANA-intake dams) was significantly higher than that of pups nursed by dams fed only on water (NANA non-intake dams). There were no significant differences in the total sialic acid or docosahexaenoic acid contents in the cerebral cortex or hippocampus of pups nursed by dams fed on either type of water. The total dimethylacetal (DMA, from plasmalogen) level in the cerebral cortex of pups nursed by NANA-intake dams was significantly higher than that of pups nursed by NANA non-intake dams. These results suggest that dietary sialic acid in dams during pregnancy and lactation might be beneficial for the learning abilities of pups after weaning, which may be related to the plasmalogen level in the brain of pups.

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“…The function of plasmalogen is not known; however, according to recent studies, plasmalogen in the PE has an antioxidant action in lowering the ability of cholesterol to be oxidized in the phospholipid bilayers as well as in the entire membranes (34,35). In addition, it has been reported that the plasmalogen concentration in the blood plasma is significantly reduced by aging and hyperlipidemia (36) and the ethanolamine plasmalogen levels of serum were lower in dementia patients of the Alzheimer's type (8,37). Based on these studies, it is considered that plasmalogen has some important functions in vivo, especially antioxidant action for maintaining and improving brain functions.…”

Section: Discussionmentioning

confidence: 99%

Effects of Dietary Docosahexaenoic Acid Connecting Phospholipids on the Learning Ability and Fatty Acid Composition of the Brain

Hiratsuka

Koizumi

Ooba³

et al. 2009

J Nutr Sci Vitaminol

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SummaryThe effects of dietary docosahexaenoic acid (DHA, C22:6 n -3) connecting phospholipids on the learning ability and fatty acid composition of the brain were investigated in hypercholesterolemic mice. ICR mice were subjected to a very low level of n -3 fatty acids through two generations. At 4 wk of age, the F 1 generation, n -3 fatty acid deficient male mice were provided with an experimental diet containing four kinds of lipids (safflower oil: Saf, DHA connecting triacylglycerols: DHA-TG, DHA connecting phospholipids: DHA-PL, soybean phospholipids: Soy-PL) for 5 wk. Another group of ICR mice were obtained and fed a commercial diet (CE-2, CLEA Japan, Inc.) as a control. The learning and memory abilities of the mice were evaluated by the modified avoidance procedure. The learning and memory ability level was significantly higher in mice fed the DHA-PL diet than in those fed the Saf and Soy-PL diets, and was the same level as the control. The DHA levels of phosphatidylethanolamine in the brain were significantly higher in the mice fed the two types of DHA-containing diets than in those fed the Saf and Soy-PL diets and was not significantly different between DHA-TG and DHA-PL. The dimethylacetal levels in the brain were significantly higher in the mice fed the DHA-PL diet than in those fed the Saf and DHA-TG diets. These results suggest that the dietary DHA connecting phospholipids have the effect of improving memory learning, and may be related to the both the DHA and plasmalogen levels in the brain.

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Plasmalogen-selective phospholipase A2 and its involvement in Alzheimer's disease

Cited by 27 publications

References 8 publications

Alterations in cerebrospinal fluid glycerophospholipids and phospholipase A2 activity in Alzheimer's disease

Alterations in cerebrospinal fluid glycerophospholipids and phospholipase A2 activity in Alzheimer's disease

Effects of Dietary Sialic Acid in n-3 Fatty Acid-Deficient Dams during Pregnancy and Lactation on the Learning Abilities of Their Pups after Weaning

Effects of Dietary Docosahexaenoic Acid Connecting Phospholipids on the Learning Ability and Fatty Acid Composition of the Brain

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