Plasmapheresis in a child with cold antibody autoimmune hemolytic anemia: case report

Özdemir, Zeynep Canan; Bör, Özcan; Dinleyici, Ener Çağrı; Kıral, Eylem

doi:10.5152/turkpediatriars.2017.2956

Cited by 3 publications

(2 citation statements)

References 11 publications

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“…That is to say, there is at least 1 joint swelling and pain, there is evidence of arthritis (clinical or ultrasound or magnetic resonance imaging), arthritis caused by other diseases is excluded, and there is a typical routine RA radiological change or meet the RA classification criteria. According to the scoring system, a total score of 6 is diagnosed as RA [18,19], as shown in Table 1.…”

Section: Early Diagnosis Of Autoimmune Antibodiesmentioning

confidence: 99%

Comprehensive Medical System for Early Diagnosis of Rheumatoid Arthritis Based on Autoimmune Antibodies

2021

Wireless Communications and Mobile Computing

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With the development of understanding of the pathogenesis of rheumatoid arthritis, it has led to the development of new treatment targets and new treatment guidelines. In the past 10 years, the treatment effect of RA patients has improved significantly. Due to the special clinical symptoms of RA, it is very important to have a clear assessment of the overall activity of the patient’s disease and timely adjustment of treatment through joint monitoring of symptoms and laboratory indicators. Clinicians have always relied on clinical manifestations and imaging progress as the key basis for diagnosis. In addition, some markers that reflect disease activity are used to aid the diagnosis of RA, but in other autoimmune diseases, these markers are usually increased. The emergence of specific autoantibodies makes it easier for clinicians to distinguish RA from other autoimmune diseases and osteoarthritis. This study collected a large number of medical records through retrospective analysis, analyzed the epidemiological data, clinical characteristics, and laboratory indicators of RA patients, and analyzed the characteristics and laboratory indicators of patients in the stable disease group and active disease group. In order to further understand the clinical features, disease activity and related factors of RA in our country, and some new biomarkers for early rheumatoid arthritis, for example, the study found that the specificity of RF for the diagnosis of RA was 71.1%, the sensitivity was 73.3%, the combined detection of anti-CCP antibody + RF increased the specificity to 97.8%, and anti-CCP the combined diagnosis of antibody+RF + GPI antigen increases the specificity of diagnosis to 100%, which significantly reduces the sensitivity compared with all tests. These autoimmune antibodies can more effectively prevent the progression of the disease in the early diagnosis and treatment of rheumatoid arthritis, achieve long-term remission, and obtain very effective therapeutic effects.

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Section: Early Diagnosis Of Autoimmune Antibodiesmentioning

confidence: 99%

Comprehensive Medical System for Early Diagnosis of Rheumatoid Arthritis Based on Autoimmune Antibodies

2021

Wireless Communications and Mobile Computing

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“…However, rather few data are available concerning the use of IVIG in CAD. A literature review revealed only one case of pediatric cold AIHA receiving IVIG, who was unresponsive to the treatment 5 . Although most published cases of AIHA received IVIG at a dose of 0.4‐0.5 mg/kg/day for five days, there is no consensus about optimal IVIG dosage.…”

Section: Figmentioning

confidence: 99%

Cold agglutinin disease in an infant: remission after intravenous immunoglobulin

Irikura

Mitani

Seki

et al. 2020

Pediatrics International

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Cold agglutinin disease (CAD) is a rare form of autoimmune hemolytic anemia (AIHA), usually caused by autoantibodies that react optimally at low temperatures. Although rituximab has been shown to be effective against adult CAD, no established treatment is available for pediatric AIHA due to its rarity in infancy and childhood. We report an infantile case of CAD that responded to intravenous immunoglobulin (IVIG) treatment. A 2-month-old previously healthy Japanese female presented with jaundice and poor feeding 3 days after receiving the first doses of Haemophilus influenzae type b conjugate vaccine and pneumococcal conjugate vaccine. No exposure to cold temperature could be identified. There was no family history of anemia, spherocytosis, or splenectomy. Physical examination revealed scleral icterus and generalized pallor, but no acrocyanosis or hepatosplenomegaly. Her laboratory data showed a hemoglobin (Hb) level of 3.8 g/dL, mean corpuscular volume of 87.3 fl, reticulocyte count of 3.4%, total bilirubin (TB) of 10.4 mg/dL, direct bilirubin of 0.8 mg/dL, lactate dehydrogenase (LDH) of 606 U/l, haptoglobin of 3 mg/dL, and no hemoglobinuria. A direct antiglobulin test (DAT) with polyspecific anti-IgG and anti-C3 was positive at 4°C and room temperature but negative at 37°C. Peripheral blood smears revealed no spherocytes. Bone marrow smears showed erythroid hyperplasia. Based on clinical signs and laboratory evaluations, we diagnosed her with cold AIHA. Further investigation concluded that monospecific DAT was positive for IgG and negative for C3. Her cold agglutinin titer was 1:16. The autoantibody was specific for the I antigen. The Donath-Landsteiner antibody test was negative, ruling out paroxysmal cold hemoglobinuria. Infectious agents were excluded with serology tests. These laboratory findings led to a diagnosis of low-titer CAD.

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Current treatment options for severe autoimmune hemolytic anemia

Yeşilbaş¹

2018

Turk Pediatri Ars

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Plasmapheresis in a child with cold antibody autoimmune hemolytic anemia: case report

Cited by 3 publications

References 11 publications

Comprehensive Medical System for Early Diagnosis of Rheumatoid Arthritis Based on Autoimmune Antibodies

Comprehensive Medical System for Early Diagnosis of Rheumatoid Arthritis Based on Autoimmune Antibodies

Cold agglutinin disease in an infant: remission after intravenous immunoglobulin

Current treatment options for severe autoimmune hemolytic anemia

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