Plasmapheresis in the Management of Acute Systemic Lupus Erythematosus?

Jones, John Verrier; Bucknall, R C; Gumming, R.; Asplin, C. M.; Fraser, I.D.; Bothamley, Joy; Davis, Paul J.; Hamblin, Terry J.

doi:10.1016/s0140-6736(76)93088-9

Cited by 224 publications

(55 citation statements)

References 6 publications

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“…If CIC are involved in the pathogenesis of rheumatoid vasculitis, plasmapheresis might rapidly remove the complexes and result in more rapid control of the vasculitis. This has been suggested as the mechanism for the beneficial effect of plasmapheresis in some patients with systemic lupus erythematosus (6,7).…”

Section: Discussionmentioning

confidence: 97%

“…At present we do not believe that the data on concurrent cytotoxic drug and plasmapheresis therapy are sufficient for us to determine just how effective this combination may be in inhibiting the rise in titer of immune complexes, although it is suggested by the laboratory results found in patients 1 and 2. Plasmapheresis therapy has reduced the level of some types of immune complexes and has resulted in clinical improvement in patients with systemic lupus erythematosus, another disease in which immune complexes are thought to play a role in pathogenesis (6,7). Rheumatoid factor, which is often a component of immune complexes in patients with RA, has been shown to be decreased or eliminated after plasmapheresis (5,16) of the patient.…”

Section: Discussionmentioning

confidence: 99%

“…Circulating immune complexes (CIC) and cryoglobulins have been correlated with the severity of RA and arteritis in some cases (3,4), and clinical improvement has often occurred when levels of cryoglobulins and CIC were lowered (3,4). Plasmapheresis has been shown to reduce the level of rheumatoid factor in patients with RA (5) and the level of CIC in those with systemic lupus erythematosus (6,7).…”

Section: Limited Plasmapheresis In Rheumatoid Arthritis With Vasculitismentioning

confidence: 99%

See 2 more Smart Citations

Limited plasmapheresis in rheumatoid arthritis with vasculitis

Goldman

Casey

McIlwain

et al. 1979

Arthritis & Rheumatism

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Section: Limited Plasmapheresis In Rheumatoid Arthritis With Vasculitismentioning

confidence: 99%

See 1 more Smart Citation

Limited plasmapheresis in rheumatoid arthritis with vasculitis

Goldman

Casey

McIlwain

et al. 1979

Arthritis & Rheumatism

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“…To date the therapeutic option of plasma exchange has been considered in almost every systemic disease. In cases of lupus nephritis, rapidly progressive glomerulonephritis concomitant to a variety of diseases, and also in rheumatoid arthritis, elimination of CIC was considered as the key issue for the effectiveness of plasma exchange [4,[7][8][9][10]. Since substitution fluids are completely free of immune complexes, plasma exchange can be very effective in acute removal of CIC if the processed plasma volumes are large enough.…”

Section: Plasma Exchangementioning

confidence: 99%

Extracorporeal Removal of Circulating Immune Complexes: From Non-Selective to Patient-Specific

Matic

Schütt²,

Winkler

et al. 2000

Blood Purif

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The classical immune complex-mediated disease, termed serum sickness, developed a short time after the injection of horse anti-tetanus toxin. Antibodies against circulating horse plasma proteins lead to the formation of immune complexes within the blood circulation (CIC). The inflammatory response, including systemic complement activation and vasculitis, seriously affected the function of all organs, including the most susceptible kidney. Meanwhile CIC have been detected in almost every systemic disease, including autoimmune disorders and also cancer and infections. This brief review will focus on the rationale and the equipment for extracorporeal elimination of CIC.

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“…Several varieties of extracorporeal immune-absorbents or apparati capable of specific removal of immune complexes have been devised (37,38). In addition, several reports of selective or batch removal of complexes using plasmapheresis in patients with active SLE have been proposed (39).…”

Section: The Problem Of Immune Complexesmentioning

confidence: 99%

Clinical immunologic studies in systemic lupus erythematosus

Williams

Bankhurst

1978

Arthritis & Rheumatism

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This review of recent and new directions in clinical immunologic studies of systemic lupus erythematosus (SLE) is restricted to the areas of lymphocyte surface markers, antigen binding lymphocytes, immune complexes, and lymphocyte hyporesponsiveness in lupus patients. First, it is not clear whether the T‐lymphopenia observed in SLE is related to viral destruction of T cells, anti‐lymphocyte antibodies, or tissue sequestration. Second, the increase in DNA‐binding B lymphocytes observed in active lupus patients may be related to minor alterations in the balance of immunoregulatory T cells or to a bypass of DNA‐specific helper T cells. Third, it is speculated that the removal of immune complexes which play a role in lupus glomerulitis by various extracorporeal immune absorbents may be important in the future therapy of SLE. Fourth, the mechanisms of T‐lymphocyte hypofunction are unexplained. It is postulated from studies done in other diseases that this hypoactivity may be mediated by the secretion of prostaglandin or other humoral agents from one leukocyte subpopulation suppressing another potentially responsive lymphocyte subpopulation. Also an investigation into the lymphocyte subpopulation reactive with virus‐infected fibroblasts may be useful in delineating immunoregulatory lymphocytes important in the pathogenesis of SLE.

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Plasmapheresis in the Management of Acute Systemic Lupus Erythematosus?

Cited by 224 publications

References 6 publications

Limited plasmapheresis in rheumatoid arthritis with vasculitis

Limited plasmapheresis in rheumatoid arthritis with vasculitis

Extracorporeal Removal of Circulating Immune Complexes: From Non-Selective to Patient-Specific

Clinical immunologic studies in systemic lupus erythematosus

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