Plasmapherisis in Covid-19 patient under ECMO: A Moroccan case report experience

Abstract

Introduction Sars-CoV-2 induces an intense cytokine response called cytokine storm at the origin of acute respiratory distress syndrome, multiple organ dysfunction syndrome and death. In this context, several treatments have been proposed; and plasmapheresis appears as a promising treatment. Case presentation We report the case of a 57-year-old patient admitted for Sars-CoV-2 infection, who requiried the use of mechanical ventilation, assistance by veno-venous extracorporeal membrane oxygenation ECMO and treated by plasmapheresis plugged on the ECMO circuit. Discussion We discuss the mechanisms responsible for the Sars-CoV-2 induced cytokine storm leading to an acute respiratory distress syndrome and the main therapeutic alternatives with emphasis on plasmapheresis. Conclusion Reduction of cytokines by plasmapheresis may be very useful in the management of Covid-19 infection if it is undertaken early even on an ECMO circuit.

Advanced Nitric Oxide Generating Nanomedicine for Therapeutic Applications

“…NO is utilized directly and through the immune system to eliminate many types of infectious agents without unduly harming the host cells and the hosts . COVID-19, which immerged in 2019 and was caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), , is responsible for more than 6.5 million deaths according to the World Health Organization (WHO) globally. This pandemic also has resulted in the loss of individual livelihoods and a global economic depression due to prolonged shutdowns.…”