Plasmid-mediated quinolone resistance: Two decades on

Rodríguez-Martínez, José Manuel; Machuca, Jesús; Cano, María Eliecer; Calvo, Jorge; Martínez-Martínez, Luis; Pascual, Álvaro

doi:10.1016/j.drup.2016.09.001

Cited by 176 publications

(180 citation statements)

References 157 publications

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“…isolates from animals [155,201]. Moreover, reports about plasmid-mediated quinolone resistance (PMQR) genes [ qnr , acc(6)-Ib-cr , qepA , oqxAB ] in bacteria from animal origin have been published since 2000s [155,180]. …”

Section: Amr-genes In Gram-negative Bacteria From Animalsmentioning

confidence: 99%

“…Some qnr genes have been described in Enterobacteriaceae (mainly Salmonella spp. and E. coli ) of animal origin [155,180,202]. Their wide distribution suggests an origin prior to the inclusion of quinolones in medicine [180].…”

Section: Amr-genes In Gram-negative Bacteria From Animalsmentioning

confidence: 99%

“…and E. coli ) of animal origin [155,180,202]. Their wide distribution suggests an origin prior to the inclusion of quinolones in medicine [180]. It has been suggested that these genes have originated in bacteria from the natural environment [20].…”

Section: Amr-genes In Gram-negative Bacteria From Animalsmentioning

confidence: 99%

“…It has been suggested that these genes have originated in bacteria from the natural environment [20]. In fact, qnr genes have been found in aquatic and waterborne organisms such as Shewanella , Aeromonas and Citrobacter species, and in the Vibrionaceae family [20,180]. …”

Section: Amr-genes In Gram-negative Bacteria From Animalsmentioning

confidence: 99%

“…As the qnr genes, PMQR efflux pump genes ( qepA and oqxAB ) have also a wide distribution, and they have been found in diverse Enterobacteriaceae from animals and humans [155,180] (Table 9). These genes are related to transmissible plasmids, although oqxAB is also commonly found in the chromosome of K. pneumoniae [180].…”

Section: Amr-genes In Gram-negative Bacteria From Animalsmentioning

confidence: 99%

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Bacteria from Animals as a Pool of Antimicrobial Resistance Genes

et al. 2017

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Antimicrobial agents are used in both veterinary and human medicine. The intensive use of antimicrobials in animals may promote the fixation of antimicrobial resistance genes in bacteria, which may be zoonotic or capable to transfer these genes to human-adapted pathogens or to human gut microbiota via direct contact, food or the environment. This review summarizes the current knowledge of the use of antimicrobial agents in animal health and explores the role of bacteria from animals as a pool of antimicrobial resistance genes for human bacteria. This review focused in relevant examples within the ESC(K)APE (Enterococcus faecium, Staphylococcus aureus, Clostridium difficile (Klebsiella pneumoniae), Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacteriaceae) group of bacterial pathogens that are the leading cause of nosocomial infections throughout the world.

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Section: Amr-genes In Gram-negative Bacteria From Animalsmentioning

confidence: 99%

Section: Amr-genes In Gram-negative Bacteria From Animalsmentioning

confidence: 99%

Section: Amr-genes In Gram-negative Bacteria From Animalsmentioning

confidence: 99%

Section: Amr-genes In Gram-negative Bacteria From Animalsmentioning

confidence: 99%

Section: Amr-genes In Gram-negative Bacteria From Animalsmentioning

confidence: 99%

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Bacteria from Animals as a Pool of Antimicrobial Resistance Genes

et al. 2017

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Fluoroquinolones

Dowling

2024

Antimicrobial Therapy in Veterinary Medicine

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Mechanisms of Resistance to Antibacterial Agents

Bradford,

Castanheira

2023

ClinMicroNow

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Bacterial pathogens have developed resistance to antibacterial agents via multiple routes. The emergence of antimicrobial resistance phenotypes is directly linked to the use of any given anti microbial agent. Resistance to aminoglycosides occurs by several different mechanisms that can coexist in the same bacterial cell. β‐Lactam antibiotics act by inhibiting penicillin‐binding proteins, which are transpeptidases and transglycosylases that synthesize the peptidogly can that composes the bacterial cell wall. The main bacterial resistance mechanism against fluoroquinolonesis is the alteration of their target in the deoxyribonucleic acid synthesis process. Tetracyclines are bacteriostatic antibiotics that inhibit bacterial growth by binding to the ribosome, thereby preventing protein synthesis. Nitrofurantoin is a synthetic antibacterial agent that is only used in the treatment of urinary tract infections. Rifampin is particularly active against Gram‐positive bacteria and mycobacteria. Daptomycin is a cyclic lipopeptide antibiotic with activity exclusively against Gram‐positive bacteria.

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Plasmid-mediated quinolone resistance: Two decades on

Cited by 176 publications

References 157 publications

Bacteria from Animals as a Pool of Antimicrobial Resistance Genes

Bacteria from Animals as a Pool of Antimicrobial Resistance Genes

Fluoroquinolones

Mechanisms of Resistance to Antibacterial Agents

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