Plasminogen Activity of Plasma and Serum

Fantl, P

doi:10.1126/science.135.3506.787

Cited by 18 publications

(8 citation statements)

References 5 publications

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“…We have confirmed that plasma and serum do not differ significantly in their plasminogen content (3,4). In addition we have found that the formation of an in vitro thrombus is not associated with loss of plasminogen from the blood from which it is made, and direct measurement of the plasminogen content of thrombi suggests that serum trapped in its interstices may account for the small amount of plasminogen found.…”

Section: Discussionsupporting

confidence: 73%

The Plasminogen Content of Thrombi

Ogston¹,

Cm²,

Hw³

1966

Thromb Haemost

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Summary1. The plasminogen content of serum and plasma does not differ. The serum remaining after the production of an in vitro artificial thrombus has a plasminogen content similar to the original plasma. Direct measurement of the plasminogen content of artificial thrombi confirms that little plasminogen is adsorbed onto fibrin during the process of clotting.2. The lysis of pre-formed artificial thrombi by urokinase is substantially increased in the presence of plasma. This is not due to free plasmin in the medium surrounding the thrombus.3. Partially purified plasminogen is adsorbed onto artificial thrombi endowing them with the capacity to lyse on the addition of urokinase. In contrast plasminogen from plasma or serum is not adsorbed onto thrombi.4. We suggest that the lysis of a thrombus results from diffusion of circulating plasminogen into the thrombus and its interaction with activator on the surface of the fibrin fibrils with consequent plasmin formation.

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Section: Discussionsupporting

confidence: 73%

The Plasminogen Content of Thrombi

Ogston¹,

Cm²,

Hw³

1966

Thromb Haemost

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“…This was different from the observation of Fantl [12] who found the same activity both in plasma and in serum. However, he had added the equi valent amounts of sodium citrate that was present in the plasma to the serum before the measurement, while we did not.…”

Section: Resultscontrasting

confidence: 52%

Plasminogen Levels in Subjects with Eosinophilia

Visudhiphan¹,

Sungnate²,

Piankijagum³

1980

Acta Haematol

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Plasminogen determinations were performed in 98 normal volunteers and 50 subjects with eosinophilia. There was no significant difference in the plasminogen levels between these two groups. Since, increased eosinophils in the bone marrow of those eosinophilic subjects were also demonstrated. This observation should raise a question as to whether the eosinophils would really be the site of systemic plasminogen synthesis.

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“…If this supposition were correct a marked difference between the plasminogen content of plasma and serum would be expected. It has been demonstrated, however, that such a difference does not or hardly exist [7].…”

Section: Discussionmentioning

confidence: 99%

The Role of Plasminogen in Fibrinolysis

Wit¹

1962

Vox Sanguinis

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Plasminogen Activity of Plasma and Serum

Cited by 18 publications

References 5 publications

The Plasminogen Content of Thrombi

The Plasminogen Content of Thrombi

Plasminogen Levels in Subjects with Eosinophilia

The Role of Plasminogen in Fibrinolysis

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