Plasmocytome pulmonaire : à propos de deux nouvelles observations et revue de la littérature

Diffuse pulmonary hemorrhage denotes a diffuse bleeding into the alveoli as a result of severe damage of the alveolocapillary membrane. Autoimmune diseases, toxic injury and hemodynamic changes are the most frequent causes. A 45 year old male patient presented with diffuse alveolar hemorrhage. An Immunoglobulin A (IgA) paraprotein secreting myeloma was found to be the underlying cause. Immunohistochemistry revealed dense pericapillary and perivascular deposits of IgA, indicating a paraprotein mediated damage of the alveolocapillary membrane. The predominantly vascular pattern of damage was regarded as the most likely cause of the pulmonary hypertension in this patient. The diffuse pulmonary bleeding stopped after initiation of treatment consisting of vincristine, adriamycine and dexamethasone.

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A rare cause of diffuse pulmonary hemorrhage in a 45 year-old man

Schreiber

Häntze

Florschütz

et al. 2006

Internist

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Bronchopulmonary manifestations of malignant hematological diseases

Schreiber

2008

Pneumologe

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Bronchopulmonale Manifestationen von malignen hämato-logischen Erkrankungen Leitthema Bronchopulmonale Verände-rungen treten bei 40-60% der Patienten mit einer malignen hämato-logischen Erkrankung auf [50, 52]. Sie können Ausdruck einer pulmonalen, bronchialen sowie pleuralen Manifestation der hämatologischen Grunderkrankung sein. Differenzialdiagnostisch müssen meist Infektionen einschließlich opportunistischer Erreger abgegrenzt werden. Weitere relevante Differenzialdiagnosen sind medikamentös induzierte Lungenschädigungen, die meist durch Zytostatika, Zytokine oder Wachstumsfaktoren, selten durch Transfusionen von Blutprodukten ausgelöst werden können, und Zweiterkrankungen und -tumore. Eine frühzeitige Diagnostik und Therapie dieser bronchopulmonalen Veränderungen kann für die Prognose der Patienten essenziell sein [65].

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A Rare Case of Solitary Plasmacytoma Mimicking a Primary Lung Tumor

Goździuk

Kedra

Rybojad

et al. 2009

The Annals of Thoracic Surgery

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Plasmocytome pulmonaire : à propos de deux nouvelles observations et revue de la littérature

Cited by 14 publications

References 34 publications

A rare cause of diffuse pulmonary hemorrhage in a 45 year-old man

A rare cause of diffuse pulmonary hemorrhage in a 45 year-old man

Bronchopulmonary manifestations of malignant hematological diseases

A Rare Case of Solitary Plasmacytoma Mimicking a Primary Lung Tumor

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