2012
DOI: 10.1371/journal.pone.0033774
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Plasmodium falciparum-Infected Erythrocytes Induce Granzyme B by NK Cells through Expression of Host-Hsp70

Abstract: In the early immune response to Plasmodium falciparum-infected erythrocytes (iRBC), Natural Killer (NK) cells are activated, which suggests an important role in innate anti-parasitic immunity. However, it is not well understood whether NK cells directly recognize iRBC or whether stimulation of NK cells depends mainly on activating signals from accessory cells through cell-to-cell contact or soluble factors. In the present study, we investigated the influence of membrane-bound host Heat shock protein (Hsp) 70 i… Show more

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Cited by 89 publications
(69 citation statements)
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“…CD57 expression was the lowest on CD56 neg CD16 pos NK cells for eBL children with high EBV loads; however, this trend did not achieve statistical significance ( Figure 5B). Despite higher expression of NKG2C described on NK cells cocultured with Pf-iRBCs, 46 we found no differences in NKG2C expression in circulating NK cells associated with malaria exposure or EBV load (comparing Kisumu and Nandi children). In contrast, eBL children with high EBV loads had the lowest expression of NKG2C on all of their NK cell subsets compared with the other groups of children ( Figure 5C).…”
Section: Nkg2d and 2b4 Coactivating Receptors Expressed By The Cd56contrasting
confidence: 76%
“…CD57 expression was the lowest on CD56 neg CD16 pos NK cells for eBL children with high EBV loads; however, this trend did not achieve statistical significance ( Figure 5B). Despite higher expression of NKG2C described on NK cells cocultured with Pf-iRBCs, 46 we found no differences in NKG2C expression in circulating NK cells associated with malaria exposure or EBV load (comparing Kisumu and Nandi children). In contrast, eBL children with high EBV loads had the lowest expression of NKG2C on all of their NK cell subsets compared with the other groups of children ( Figure 5C).…”
Section: Nkg2d and 2b4 Coactivating Receptors Expressed By The Cd56contrasting
confidence: 76%
“…Comparably, P. falciparum bears one designated metacaspase, P. falciparum MCA-1 (35), which may be the target of Gb. Another hypothesis is that Gb induces eryptosis in infected erythrocytes and thus kills the parasite (7).…”
Section: Figmentioning
confidence: 99%
“…There is no effective vaccine against these parasites (3,4), and resistances are emerging against a wide variety of antimalarial drugs (5). It was recently shown in vitro that natural killer (NK) cells can eliminate erythrocytes infected with P. falciparum (6) and that this is associated with the production of the serine protease granzyme B (Gb) (7). In vivo, NK cells are essential for protection against plasmodial infections in mice (8), and increased levels of circulating Gb are found in naturally infected humans (9).…”
mentioning
confidence: 99%
“…In addition to their activity against tumors and virus-infected cells, NK cells are capable of responding to protozoan pathogens including plasmodia. Although an innate response to Plasmodium species is often overlooked, human NK cells upon exposure to Plasmodium falciparum -infected erythrocytes respond by producing IFN-γ, which could be vital in immunity to malaria [18][19][20] . In addition to IFN-γ, NK cells have also been reported to produce granzyme B (GB) in response to Plasmodium species [18] .…”
Section: Introductionmentioning
confidence: 99%