Plasmodium falciparum parasitaemia in the first half of pregnancy, uterine and umbilical artery blood flow, and foetal growth: a longitudinal Doppler ultrasound study

Griffin, Jennifer B.; Lokomba, Victor; Landis, Sarah H.; Thorp, John M.; Herring, Amy H.; Tshefu, Antoinette; Rogerson, Stephen J.; Meshnick, Steven R.

doi:10.1186/1475-2875-11-319

Cited by 74 publications

(75 citation statements)

References 49 publications

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“…Showing a medicine is sufficiently well tolerated in populations with different risk–benefit profiles, such as those with asymptomatic infections [16], pregnant women [34], infants [35], and patients with other co-morbidities, such as human immunodeficiency virus (HIV) and tuberculosis (TB) co-infection, or malnutrition, adds complexity. One medicine may not serve all these groups.…”

Section: The Single-exposure Cure Dilemma: Efficacy Versus Safety In mentioning

confidence: 99%

New developments in anti-malarial target candidate and product profiles

Burrows

Duparc

Gutteridge

et al. 2017

Malar J

424

480

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A decade of discovery and development of new anti-malarial medicines has led to a renewed focus on malaria elimination and eradication. Changes in the way new anti-malarial drugs are discovered and developed have led to a dramatic increase in the number and diversity of new molecules presently in pre-clinical and early clinical development. The twin challenges faced can be summarized by multi-drug resistant malaria from the Greater Mekong Sub-region, and the need to provide simplified medicines. This review lists changes in anti-malarial target candidate and target product profiles over the last 4 years. As well as new medicines to treat disease and prevent transmission, there has been increased focus on the longer term goal of finding new medicines for chemoprotection, potentially with long-acting molecules, or parenteral formulations. Other gaps in the malaria armamentarium, such as drugs to treat severe malaria and endectocides (that kill mosquitoes which feed on people who have taken the drug), are defined here. Ultimately the elimination of malaria requires medicines that are safe and well-tolerated to be used in vulnerable populations: in pregnancy, especially the first trimester, and in those suffering from malnutrition or co-infection with other pathogens. These updates reflect the maturing of an understanding of the key challenges in producing the next generation of medicines to control, eliminate and ultimately eradicate malaria.

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Section: The Single-exposure Cure Dilemma: Efficacy Versus Safety In mentioning

confidence: 99%

New developments in anti-malarial target candidate and product profiles

Burrows

Duparc

Gutteridge

et al. 2017

Malar J

424

480

View full text Add to dashboard Cite

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“…iE sequestration leads to acute vascular modifications of placental villi, reducing the available surface for feto-placental exchanges. This decrease may be correlated with intra-uterine growth retardation [9, 10]. The blood flow modifications by the accumulation of iEs in the intervillous spaces originate ST hypoxia and angiogenesis deregulation.…”

Section: Introductionmentioning

confidence: 99%

“…Some authors described similar seasonal changes in the incidence of both preeclampsia and PAM, with increased incidence during the rainy season [38, 39]. Clinically, reduced placental perfusion is a common link between these pathologies that are associated with fetal growth restriction [10, 40]. Indeed, preeclampsia translates into a high arterial blood pressure, a glomerular renal disease with proteinuria, and can be complicated by lung edema, renal insufficiency, and eclampsia.…”

Section: Introductionmentioning

confidence: 99%

Usefulness of a biomarker to identify placental dysfunction in the context of malaria

Gueneuc

Deloron

Bertin

2017

Malar J

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In most tropical areas, pregnant women are at increased risk of malaria, as a consequence of the massive sequestration of parasitized red blood cells in the placenta. The placenta plays a key role in embryonic and fetal development as well as in maternal-fetal exchanges, and pregnancy-associated malaria may alter selected placenta functions that lead to stillbirth and low birth weight. Although there are several tools (blood smear examination, RDT, PCR) to diagnose malaria infection during pregnancy, there is currently no test to assess placenta dysfunction in the framework of pregnancy-associated malaria. Pregnancy-associated malaria shares many features with preeclampsia, an extensively studied disease. Various biomarkers associated with placental dysfunction have been identified as associated with preeclampsia. Several of these are inflammatory markers that lack of specificity. A few seem more specific of placenta dysfunction, including s-endoglin and sFlt1, increased in the peripheral blood during preeclampsia. The predictive value of these biomarkers should be studied in the context of pregnancy-associated malaria to evaluate their usefulness in identifying placental dysfunction during malaria. These biomarkers should be considered to improve the diagnosis of placental dysfunction during malaria and pregnant women monitoring.

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“…7,8 The umbilical artery was identified using color Doppler interrogation. 7 Pulsed Doppler with a gate size of 2 mm was applied.…”

Section: Umbilical Artery Dopplermentioning

confidence: 99%

The value of colour doppler assessment of the uteroplacental circulation in predicting intrauterine growth restriction

Dhakar

Naz

2017

Int J Reprod Contracept Obstet Gynecol

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Since there are several methods to identify, clinically the most common method of detecting IUGR is the serial measurement of fundal height and abdominal growth. Symphysio-fundal height normally increases by 1cm per ABSTRACT Background: Intrauterine growth restriction is a complication that arises due to decrease in uteroplacental blood flow during pregnancy. This decrease is associated with a pathological condition of spiral arteries thought to arise during placentation in first trimester of pregnancy. Thus, it might be possible to predict the development of these conditions by assessing uteroplacental blood flow in pregnancy with colour Doppler. The aim of the study was to assess the findings of Doppler data in predicting IUGR and finding the best predictors of IUGR in uterine and umbilical artery Doppler. Methods: In this prospective study, total of 100 women with high risk pregnancy attending Department of Obstetrics and Gynecology at Geetanjali Medical College and Hospital, Udaipur were subjected to uterine and umbilical artery Doppler Study. Women with high risk pregnancy between 26-32 weeks of gestation were studied with colour Doppler. This study was carried over a period of 1 year from 2015-2016. Results: Out of total 100 patients, 8 were found to have IUGR. Out of different parameters, Notch is the best indicator with high sensitivity and highest positive predictive value (PPV) of 50% followed by combination of parameter as it had the highest sensitivity of 62.5% for uterine artery Doppler. S/D Ratio is the best indicator with high sensitivity and highest positive predictive value (PPV) of 25% and 40% respectively followed by RI with highest sensitivity of 42.86% for umbilical artery Doppler. Conclusions: Value of Doppler assessment of uteroplacental circulation in predicting IUGR and is very useful in improving pregnancy outcome.

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Plasmodium falciparum parasitaemia in the first half of pregnancy, uterine and umbilical artery blood flow, and foetal growth: a longitudinal Doppler ultrasound study

Cited by 74 publications

References 49 publications

New developments in anti-malarial target candidate and product profiles

New developments in anti-malarial target candidate and product profiles

Usefulness of a biomarker to identify placental dysfunction in the context of malaria

The value of colour doppler assessment of the uteroplacental circulation in predicting intrauterine growth restriction

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