2015
DOI: 10.1182/blood-2014-08-596015
|View full text |Cite
|
Sign up to set email alerts
|

Plasmodium vivax: restricted tropism and rapid remodeling of CD71-positive reticulocytes

Abstract: Key Points• Plasmodium vivax merozoites preferentially infect a subgroup of reticulocytes generally restricted to the bone marrow.• Accelerated "maturation" of infected reticulocytes.Plasmodium vivax merozoites only invade reticulocytes, a minor though heterogeneous population of red blood cell precursors that can be graded by levels of transferrin receptor (CD71) expression. The development of a protocol that allows sorting reticulocytes into defined developmental stages and a robust ex vivo P vivax invasion … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

6
216
0
3

Year Published

2015
2015
2024
2024

Publication Types

Select...
7
1

Relationship

1
7

Authors

Journals

citations
Cited by 172 publications
(225 citation statements)
references
References 53 publications
6
216
0
3
Order By: Relevance
“…One of the characteristics of P vivax-infected RBCs is the dramatic transformation of the rigid reticulocytes into a deformable cell within the space of 6 hours, 30,31 a normal maturation process that normally takes at least 48 hours for uninfected reticulocytes. 32 This is also observed with P cynomolgiinfected human reticulocytes, as shown by the drop in the shear modulus for these cells ( Figure 3B). It was interesting to note that for both human-and macaque-infected RBCs, deformability increased as the parasites matured to schizonts ( Figure 3B).…”
Section: Duffy-dependence For the Invasion Of Human Reticulocytessupporting
confidence: 50%
“…One of the characteristics of P vivax-infected RBCs is the dramatic transformation of the rigid reticulocytes into a deformable cell within the space of 6 hours, 30,31 a normal maturation process that normally takes at least 48 hours for uninfected reticulocytes. 32 This is also observed with P cynomolgiinfected human reticulocytes, as shown by the drop in the shear modulus for these cells ( Figure 3B). It was interesting to note that for both human-and macaque-infected RBCs, deformability increased as the parasites matured to schizonts ( Figure 3B).…”
Section: Duffy-dependence For the Invasion Of Human Reticulocytessupporting
confidence: 50%
“…As expected with P. yoelii, most infected erythrocytes were CD71 + reticulocytes (19) (Figure 1A). Parasitemia reached a peak of approximately 20% infected erythrocytes at approximately 15 days after infection in cGAS +/+ P. yoelii-infected mice and was cleared 18-21 days after infection (20).…”
Section: Cgas-sting-type I Interferon Signals Contribute To Control Omentioning
confidence: 55%
“…The latter is (partly) attributed to the multiple invaginations observed on the infected red cell surface, i.e. caveola vesicle complexes containing P. vivax-encoded antigens (del Portillo et al 2004;Suwanarusk et al 2004;Malleret et al 2015). Due to this increased deformability, P. vivax-iRBCs pass easily through the interendothelial slits of the sinuses, thereby avoiding splenic entrapment.…”
Section: Endothelial Cytoadherence and Spleen Remodelingmentioning
confidence: 99%
“…This severely reduces the number of host cells available for invasion (typically <1-2% of all RBCs) and limits parasitemia unless anemia drives reticulocytosis to higher levels. Moreover, P. vivax and P. yoelii 17XNL preferentially invade immature CD71 hi reticulocytes, whose presence is largely restricted to erythropoietic tissues (Martin-Jaular et al 2013;Malleret et al 2015). Plasmodium falciparum, P. knowlesi, particular rodent parasites including P. chabaudi and some strains of P. yoelii and P. berghei also invade normocytes and, therefore, give rise to higher parasite loads.…”
Section: Intrinsic Growth Rate and Host Cell Preferencementioning
confidence: 99%
See 1 more Smart Citation