2015
DOI: 10.1002/anie.201504027
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Plasmonic Colloidosomes as Three‐Dimensional SERS Platforms with Enhanced Surface Area for Multiphase Sub‐Microliter Toxin Sensing

Abstract: Colloidosomes are robust microcapsules attractive for molecular sensing because of their characteristic micron size, large specific surface area, and dual-phase stability. However, current colloidosome sensors are limited to qualitative fluorogenic receptor-based detection, which restrict their applicability to a narrow range of molecules. Here, we introduce plasmonic colloidosome constructed from Ag nanocubes as an emulsion-based 3D SERS platform. The colloidosomes exhibit excellent mechanical robustness, fle… Show more

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Cited by 102 publications
(115 citation statements)
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“…Within this concentration range, the SERS intensity at 1,362 cm −1 (C-C stretching mode of R6G) can be expressed quantitatively by an empirical equation, logC = 1.85logI − 17.01, where C is the R6G concentration expressed in molar concentration and I is the SERS intensity level (counts per second) (37,38). The ability to achieve quantitative detection down to ∼75 fM is at least three orders of magnitude lower than conventional SERS substrates that do not use the analyte enrichment technique (39). When the concentration is higher than 75 pM, all of the SERS hot spots in the Au nanoparticle aggregates will be occupied by the analyte molecules.…”
Section: Resultsmentioning
confidence: 99%
“…Within this concentration range, the SERS intensity at 1,362 cm −1 (C-C stretching mode of R6G) can be expressed quantitatively by an empirical equation, logC = 1.85logI − 17.01, where C is the R6G concentration expressed in molar concentration and I is the SERS intensity level (counts per second) (37,38). The ability to achieve quantitative detection down to ∼75 fM is at least three orders of magnitude lower than conventional SERS substrates that do not use the analyte enrichment technique (39). When the concentration is higher than 75 pM, all of the SERS hot spots in the Au nanoparticle aggregates will be occupied by the analyte molecules.…”
Section: Resultsmentioning
confidence: 99%
“…By employing SERS-active particles with suitable wettability as the building block, it is possible to fabricate plasmonic Pickering emulsions as the SERS observation platform for multiphase detection. For example, surface-modified Ag nanocubes were used for constructing plasmonic colloidsomes as three-dimensional multiplex sensing platforms for ultratrace detection of both aqueous and organic soluble toxins low to subfemtomole level [88]. Because of the emulsion-based structure, only sub-microliter sample volume is needed.…”
Section: +mentioning
confidence: 99%
“…By comparison, pH 2 colloidosomes display an approximately five-fold weaker red color intensity,a so bserved in the same SERS image.W e observe an approximately 10-fold slower initial formation rate of HDY + in pH 2colloidosomes relative to that for pH 1 colloidosomes (initial gradients of R I vs.t ime plot: 0.224 min À1 and 0.029 min À1 for pH 1a nd pH 2, respectively), [18] which obeys the first-order kinetics of our model interfacial reaction (rate = k app [H + ]; Figure 4A;S upporting Information, Figure S16). We exclude errors resulting from cross-talking between closely spaced plasmonic colloidosomes, [8] as well as those arising from SERS activity arising from pH-induced effects on the Ag shell (Supporting Information, Figure S17). We exclude errors resulting from cross-talking between closely spaced plasmonic colloidosomes, [8] as well as those arising from SERS activity arising from pH-induced effects on the Ag shell (Supporting Information, Figure S17).…”
Section: Angewandte Chemiementioning
confidence: 99%
“…[8] Featuring ahigh density of intense SERS hot spots,u ltrasensitive plasmonic colloidosomes provide specific molecular vibrational fingerprints simultaneously across the immiscible liquids. [8] Featuring ahigh density of intense SERS hot spots,u ltrasensitive plasmonic colloidosomes provide specific molecular vibrational fingerprints simultaneously across the immiscible liquids.…”
mentioning
confidence: 99%