Plasmonic Nanosensors for Imaging Intracellular Biomarkers in Live Cells

Kumar, Sonia; Harrison, Nathan; Richards‐Kortum, Rebecca; Sokolov, Konstantin

doi:10.1021/nl070365i

Cited by 219 publications

(198 citation statements)

References 27 publications

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“…Upon exposure to light, free electrons in gold atoms are excited to a state of collective oscillation known as surface plasmon resonance (SPR), conferring gold the ability to absorb and scatter visible light [32] . In labelling applications, AuNPs are targeted and accumulated at the site of interest and based on their optical scattering properties, they enable visualization of the region under study.…”

Section: Applications Of Aunps In Cancer Managementmentioning

confidence: 99%

Gold nanoparticles in cancer therapy

et al. 2011

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The rapid advancement of nanotechnology in recent years has fuelled a burgeoning interest in the field of nanoparticle research, in particular, its application in the medical arena. A constantly expanding knowledge based on a better understanding of the properties of gold nanoparticles (AuNPs) coupled with relentless experimentation means that the frontiers of nanotechnology are constantly being challenged. At present, there seems to be heightened interest in the application of AuNPs to the management of cancer, encompassing diagnosis, monitoring and treatment of the disease. These efforts are undertaken in the hope of revolutionizing current methods of treatment and treatment strategies for a multifactorial disease such as cancer. This review will focus on the current applications of AuNPs in cancer management.

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Section: Applications Of Aunps In Cancer Managementmentioning

confidence: 99%

Gold nanoparticles in cancer therapy

et al. 2011

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“…Other approaches are the use of AuNPs as a core/seed that can be tailored with a wide variety of surface functionalities to provide highly selective nanoprobes for diagnosis (You et al, 2007); the utilization of Surface Plasmon resonance (SPR) scattering imaging or SPR absorption spectroscopy generated from antibody conjugated AuNPs in molecular biosensor techniques for the diagnosis and investigation of oral epithelial living cancer cells in vivo and in vitro (El-Sayed et al, 2005a); the use of multifunctional AuNPs which incorporate both cytosolic delivery and targeting moieties on the same particle functioning as intracellular sensors to monitoring actin rearrangement in live fibroblasts (Kumar et al, 2007); and the employment of AuNPs in electrochemical based methods that can be coupled with metal deposition for signal enhancement (Castaneda et al, 2007).…”

Section: Nanodiagnosticsmentioning

confidence: 99%

Multifunctional Gold Nanocarriers for Cancer Theranostics: From Bench to Bedside and Back Again?

Conde

Tian²,

Baptista

et al. 2014

Nano-Oncologicals

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After a quarter of century of rapid technological advances, research has revealed the complexity of cancer, a disease intimately related to the dynamic transformation of the genome. However, the full understanding of the molecular onset of this disease is still far from achieved and the search for mechanisms of treatment will follow closely.It is here that Nanotechnology enters the fray offering a wealth of tools to diagnose and treat cancer.It is indisputable that the use of gold nanocarriers has been gaining momentum as vectors for therapy and diagnostic strategies, combining the AuNPs' ease of functionalization with numerous biomolecules, high loading capacity and fast uptake by target cells. In fact, over the last decade nearly 12.000 research papers focusing on multifunctional gold nanocarriers have been published in peer-reviewed journals. Some of the described nanosystems will most likely revolutionize our understanding of biological mechanisms and push forward the clinical practice through their 2 integration in future diagnostics platforms. Nevertheless, very little gave fruitful results in order to improve a bench-to-bedside approach to translational research. On the basis of theoretical and experimental results obtained so far are we or not at the point: from bench to bedside and back again? As you will see, the answers to this question are complex, but one thing is clear: Translation into clinics is a tortuous and difficult path. Here, we provide a critical review about the available multifunctional gold nanocarriers for in vitro application and in vivo cancer targeting on nanodiagnostics and therapy.

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“…Absorption of radiation is significantly enhanced at the frequency of the nanoparticle surface plasmon resonance. Biomedicine and biotechnology probably are one of the most promising applications of plasmonic nanoparticles [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22].…”

Section: Introductionmentioning

confidence: 99%

New ideally absorbing Au plasmonic nanostructures for biomedical applications

Zakomirnyi

Rasskazov

Карпов

et al. 2017

Journal of Quantitative Spectroscopy and Radiative Transfer

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In this paper a new set of plasmonic nanostructures operating at the conditions of an ideal absorption [1] was proposed for novel biomedical applications. We consider spherical x/Au nanoshells and Au/x/Au nanomatryoshkas, where 'x' changes from conventional Si and SiO 2 to alternative plasmonic materials [2], such as zinc oxide doped with aluminum, gallium and indium tin oxide. The absorption peak of proposed nanostructures lies within 700-1100nm wavelength region and corresponds to the maximal optical transparency of hemoglobin and melanin as well as to the radiation frequency of available pulsed medical lasers. It was shown that the ideal absorption takes place in a given wavelength region for Au coatings with thickness less than 12nm. In this case finite quantum size effects for metallic nanoshells play significant role. The mathematical model for the search of the ideal absorption conditions was modified by taking into account the finite quantum size effects.

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Plasmonic Nanosensors for Imaging Intracellular Biomarkers in Live Cells

Cited by 219 publications

References 27 publications

Gold nanoparticles in cancer therapy

Gold nanoparticles in cancer therapy

Multifunctional Gold Nanocarriers for Cancer Theranostics: From Bench to Bedside and Back Again?

New ideally absorbing Au plasmonic nanostructures for biomedical applications

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