Plasmonic Photothermal Therapy of Atherosclerosis With Nanoparticles: long-term Outcomes and Safety in NANOM-FIM Trial

Kharlamov, Alexander; Feinstein, John Alexander; Cramer, John Alexander; Boothroyd, John A; Шишкина, Е. В.; Shur, V. Ya.

doi:10.2217/fca-2017-0009

Cited by 77 publications

(52 citation statements)

References 46 publications

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“…13 Extending the fundamental research into clinical trials, a first- in-man trial has been completed, where silica coated AuNPs have been bioengineered into a transplantation patch that was implanted onto a cardiac artery in patients with atherosclerosis (ClinicalTrials.gov Identifier: NCT01270139). 14 AuNPs are of particular interest because of their biocompatibility and their ability to be surface functionalized and used as a delivery vehicle. Further, AuNPs have useful optical properties due to their surface plasmon resonance (SPR), which is the collective oscillation of electrons on the nanoparticle surface.…”

Section: Introductionmentioning

confidence: 99%

Characterizing the Surface Coverage of Protein–Gold Nanoparticle Bioconjugates

2018

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Functional enzyme-nanoparticle bioconjugates are increasingly important in biomedical and biotechnology applications such as drug delivery and biosensing. Optimization of the function of such bioconjugates requires careful control and characterization of their structures and activity, but current methods are inadequate for this purpose. A key shortcoming of existing approaches is the lack of an accurate method for quantitating protein content of bioconjugates for low (monolayer) surface coverages. In this study, an integrated characterization methodology for protein-gold nanoparticle (AuNP) bioconjugates is developed, with a focus on site-specific attachment and surface coverage of protein on AuNPs. Single-cysteine-containing mutants of dihydrofolate reductase are covalently attached to AuNPs with diameters of 5, 15, and 30 nm, providing a range of surface curvature. Site-specific attachment to different regions of the protein surface is investigated, including attachment to a flexible loop versus a rigid α helix. Characterization methods include SDS-PAGE, UV-vis spectrophotometry, dynamic light scattering, and a novel fluorescence-based method for accurate determination of low protein concentration on AuNPs. An accurate determination of both protein and AuNP concentration in conjugate samples allows for the calculation of the surface coverage. We find that surface coverage is related to the surface curvature of the AuNP, with a higher surface coverage observed for higher surface curvature. The combination of these characterization methods is important for understanding the functionality of protein-AuNP bioconjugates, particularly enzyme activity.

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Section: Introductionmentioning

confidence: 99%

Characterizing the Surface Coverage of Protein–Gold Nanoparticle Bioconjugates

2018

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“…Very recently, a study has reported the clinical applicability of MNPs based on a silica‐Au nanoparticles‐dispersed on‐artery patch for cardiac tissue engineering applications 4b. It was concluded that there were no significant toxic effects or serious clinical complications in the group of patients during the clinical intervention . Although the study is not within the scope of the M‐MSNs, it is noteworthy to discuss these facts, which will help in giving better insight to the readers.…”

Section: Potential Applicationsmentioning

confidence: 97%

Metal Species–Encapsulated Mesoporous Silica Nanoparticles: Current Advancements and Latest Breakthroughs

Kankala

Zhang

Liu

et al. 2019

Adv Funct Materials

135

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Despite their advantageous morphological attributes and attractive physicochemical properties, mesoporous silica nanoparticles (MSNs) are merely supported as carriers or vectors for a reason. Incorporating various metal species in the confined nanospaces of MSNs (M-MSNs) significantly enriches their mesoporous architecture and diverse functionalities, bringing exciting potentials to this burgeoning field of research. These incorporated guest species offer enormous benefits to the MSN hosts concerning the reduction of their eventual size and the enhancement of their performance and stability, among other benefits. Substantially, the guest species act through contributing to reduced aggregation, augmented durability, ease of long-term storage, and reduced toxicity, attributes that are of particular interest in diverse fields of biomedicine. In this review, the first aim is to discuss the current advancements and latest breakthroughs in the fabrication of M-MSNs, emphasizing the pros and cons, the confinement of various metal species in the nanospaces of MSNs, and various factors influencing the encapsulation of metal species in MSNs. Further, an emphasis on potential applications of M-MSNs in various fields, including in adsorption, catalysis, photoluminescence, and biomedicine, among others, along with a set of examples is provided. Finally, the advances in M-MSNs with perspectives are summarized.(2-5 nm), tunable sizes (50-150 nm), shapes (hexagonal, wormhole-like, cubic, and lamellar) and morphologies (spheres, helical fibers, tubules, gyroids, crystals, and numerous other hierarchical complex architectures), ease of surface functionalization (both interior as well as exterior), unique topology, colloidal and thermal stabilities, and high dispersity. [4] The exceptional topology of surfactant-templated MSNs makes them unique with desirable properties that can be obtained by controlling the preparation conditions, such as the reaction temperature, pH value, stirring speed, and type of silica source, as well as surfactant, among others. [4j,m,n,5] These advantages make the MSNs as versatile materials and ideal choice for catalysis, [6] adsorption, [7] optical devices, [4j] polymeric fillers, [8] and diverse biomedical applications including bio-imaging, [4r,t,u,9] biocatalysts, [10] biosensing, [11] tissue engineering, [4f ] and drug/ gene delivery accounting for targeted and controlled release systems. [3d,4i,o-t,v,12] With these significant advantages and attractive physicochemical properties, it is highly anticipated to harness the desirable and beneficial properties of MSNs through the incorporation of various metals and their respective conjugates for exploration in innovative applications with exceptional performance. [13] The encapsulated metal species in the confined nanospaces of MSNs (M-MSNs) not only significantly enrich the mesoporous architecture and functionalities of MSN, but also tend to overcome their intrinsic limitations, such as their poor suspension ability and stability, lack of intrig...

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“…A lot of in vitro and preclinical studies have employed doxorubicin encapsulated inside micelle, metallic nanoparticles and also nanodiamonds. These formulations also demonstrated a slower drug plasma clearance, enhanced circulation and half-life [ 126 , 127 , 128 , 129 ].…”

Section: Natural Products and Drug Delivery In Oncologymentioning

confidence: 99%

Drug Delivery Systems of Natural Products in Oncology

Colone¹,

Calcabrini²,

Stringaro³

2020

Molecules

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In recent decades, increasing interest in the use of natural products in anticancer therapy field has been observed, mainly due to unsolved drug-resistance problems. The antitumoral effect of natural compounds involving different signaling pathways and cellular mechanisms has been largely demonstrated in in vitro and in vivo studies. The encapsulation of natural products into different delivery systems may lead to a significant enhancement of their anticancer efficacy by increasing in vivo stability and bioavailability, reducing side adverse effects and improving target-specific activity. This review will focus on research studies related to nanostructured systems containing natural compounds for new drug delivery tools in anticancer therapies.

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Plasmonic Photothermal Therapy of Atherosclerosis With Nanoparticles: long-term Outcomes and Safety in NANOM-FIM Trial

Abstract: NANOM first-in-man trial demonstrates high safety with better rate of mortality, major adverse cardiovascular events and target lesion revascularization at the long-term follow-up if compare with stent XIENCE V.

Cited by 77 publications

References 46 publications

Characterizing the Surface Coverage of Protein–Gold Nanoparticle Bioconjugates

Characterizing the Surface Coverage of Protein–Gold Nanoparticle Bioconjugates

Metal Species–Encapsulated Mesoporous Silica Nanoparticles: Current Advancements and Latest Breakthroughs

Drug Delivery Systems of Natural Products in Oncology

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