Plastic Antibodies for Cosmetics: Molecularly Imprinted Polymers Scavenge Precursors of Malodors

Abstract

Molecularly imprinted polymers (MIPs) are synthetic antibody mimics capable of specific molecular recognition. Advantageously, they are more stable, easy to tailor for a given application and less expensive than antibodies. These plastic antibodies are raising increasing interest and one relatively unexplored domain in which they could outplay these advantages particularly well is cosmetics. Here, we present the use of a MIP as an active ingredient of a cosmetic product, for suppressing body odors. In a dermo-cosmetic formulation, the MIP captures selectively the precursors of malodorous compounds, amidst a multitude of other molecules present in human sweat. These results pave the way to the fabrication of a novel generation of MIPs with improved selectivities in highly complex aqueous environments, and should be applicable to biotechnological and biomedical areas as well.

Molecularly Imprinted Polymer Coated Quantum Dots for Multiplexed Cell Targeting and Imaging

“…We previously reported 400 nm rhodamine‐labeled MIP particles specific for GlcA that could only target the extracellular hyaluronan of the cell glycocalix . We have now synthesized a dedicated stoichiometric functional monomer, (4‐acrylamidophenyl)(amino)methaniminium acetate, a polymerizable benzamidine referred to as AB in the text (see the Supporting Information for the synthesis of AB; see also Figure S3), which can form strong electrostatic interactions with the −COOH moiety of GlcA and NANA. Commonly, boronate‐based monomers are employed for targeting NANA and other monosaccharides, but the use of only noncovalent interactions is preferred for sugar imprinting in terms of binding and exchange kinetics …”

“…[12][13][14][15] Consequences include effects on tumor growth, escape from apoptosis,m etastasis formation, and resistance to therapy.P olysaccharides involved in the glycosylation procedure have ah ighly conserved simple composition and are ubiquitously expressed in all animals that have ad eveloped immune response.T he natural production of antibodies that specifically recognize these "weak antigens" is difficult; [16] hence,traditional immunohistochemical methods for detecting glycosylations on cells are rare.A na lternative would be "plastic antibodies" or MIPs. [23] We have now synthesized ad edicated stoichiometric functional monomer, [26] (4-acrylamidophenyl)(amino)methaniminium acetate,apolymerizable benzamidine referred to as AB in the text (see the Supporting Information for the synthesis of AB;s ee also Figure S3), which can form strong electrostatic interactions with the ÀCOOH moiety of GlcA and NANA.C ommonly, boronate-based monomers are employed [25,27] for targeting NANA and other monosaccharides,b ut the use of only noncovalent interactions is preferred for sugar imprinting in terms of binding and exchange kinetics. [23][24][25] In this study,M IP-coated QDs were applied for the first time for the simultaneous multiplexed pseudoimmunolabeling and imaging of human keratinocytes.C ore-shell MIP nanoparticles for GlcA and NANA,( 125 AE 17) nm in size, were obtained, thus enabling the specific targeting of both intracellular and pericellular terminal glycosylations.W e previously reported 400 nm rhodamine-labeled MIP particles specific for GlcA that could only target the extracellular hyaluronan of the cell glycocalix.…”

An Epitope‐Imprinted Biointerface with Dynamic Bioactivity for Modulating Cell–Biomaterial Interactions

“…The imprinting was subsequently performed between the cover glass with the immobilized epitope and a methacrylate‐modified quartz substrate (10 mm in diameter). The polymerization reaction was photochemically initiated by a UV lamp after dripping 3 μL of a phosphate buffer solution (PBS, 0.02 m , pH 7.4) containing 1 m 2‐hydroxyethyl acrylamide (hydrophilic backbone monomer), 0.01 m 4‐acrylamidophenyl(amino)methaniminium chloride (benzamidine‐bearing monomer; see Figure S2), and 0.05 m methylenebisacrylamide (cross‐linker) onto the cover glass. By polymerization and peeling of the cover glass, a peptide‐imprinted layer (ca.…”

Label-Free Detection of Small Organic Molecules by Molecularly Imprinted Polymer Functionalized Thermocouples: Toward In Vivo Applications

“…Recently, Haupt et al presented work with polymeric receptors as an active ingredient in a cosmetic product, where MIPs acts as specific scavengers to trap nonodorous precursors of malodors. 15 …”