2023
DOI: 10.1084/jem.20230930
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Plasticity of intragraft alloreactive T cell clones in human gut correlates with transplant outcomes

Jianing Fu,
Zicheng Wang,
Mercedes Martinez
et al.

Abstract: The site of transition between tissue-resident memory (TRM) and circulating phenotypes of T cells is unknown. We integrated clonotype, alloreactivity, and gene expression profiles of graft-repopulating recipient T cells in the intestinal mucosa at the single-cell level after human intestinal transplantation. Host-versus-graft (HvG)–reactive T cells were mainly distributed to TRM, effector T (Teff)/TRM, and T follicular helper compartments. RNA velocity analysis demonstrated a trajectory from TRM to Teff/TRM cl… Show more

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Cited by 8 publications
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“…The distribution pattern of B cells in the lamina propria of intestinal mucosa beyond the lymphoid follicles has not been reported for human infants. We hypothesize that this distribution may be patchy, in contrast to a more diffuse mucosal distribution pattern for T cells, on the basis of our observations from staining of CD20 + B cells and CD3 + T cells in intestinal mucosa during quiescence after ITx (30), and from our observations of fluctuating recipient B cell contributions to intestinal allograft biopsies taken from different sites at adjacent timepoints (Supplementary Figure 1A). In contrast, recipient T cell representation in these biopsies tends to be more stable at adjacent timepoints (23,25,39).…”
Section: Discussionmentioning
confidence: 83%
“…The distribution pattern of B cells in the lamina propria of intestinal mucosa beyond the lymphoid follicles has not been reported for human infants. We hypothesize that this distribution may be patchy, in contrast to a more diffuse mucosal distribution pattern for T cells, on the basis of our observations from staining of CD20 + B cells and CD3 + T cells in intestinal mucosa during quiescence after ITx (30), and from our observations of fluctuating recipient B cell contributions to intestinal allograft biopsies taken from different sites at adjacent timepoints (Supplementary Figure 1A). In contrast, recipient T cell representation in these biopsies tends to be more stable at adjacent timepoints (23,25,39).…”
Section: Discussionmentioning
confidence: 83%