Plasticity of the human motor cortex and recovery from stroke

Hallett, Mark

doi:10.1016/s0165-0173(01)00092-3

Cited by 319 publications

(195 citation statements)

References 64 publications

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“…Stinear and Byblow argued that progress toward motor recovery may be advanced when patients received rehabilitation protocols within Stroke, NIBS, and Rehabilitation 15 six months post a stroke, during the spontaneous recovery period [69]. Specifically, the effects of neuromodulation interventions on neural plasticity and reorganization of brain activation between hemispheres may increase during the spontaneous recovery period in comparison to the chronic stage [69,70]. Thus, further studies investigating the different effects of NIBS techniques based on post stroke recovery stages will be necessary.…”

Section: Discussionmentioning

confidence: 99%

Non-Invasive Brain Stimulation Improves Paretic Limb Force Production: A Systematic Review and Meta-Analysis

2016

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Section: Discussionmentioning

confidence: 99%

Non-Invasive Brain Stimulation Improves Paretic Limb Force Production: A Systematic Review and Meta-Analysis

2016

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“…Motor networks in surviving peri-infarct regions, as well as the undamaged contralateral homotopic cortex and subcortical structures, demonstrate significant reorganization after stroke [55][56][57]. Plasticity in these areas is believed to support functional recovery [58]. As detailed above, a study from Porter et al [36] demonstrated that VNS paired with forelimb training drives robust, specific plasticity within motor cortex.…”

Section: Preclinical and Clinical Studies For Ischemic Strokementioning

confidence: 99%

Enhancing Rehabilitative Therapies with Vagus Nerve Stimulation

Hays

2016

Neurotherapeutics

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Pathological neural activity could be treated by directing specific plasticity to renormalize circuits and restore function. Rehabilitative therapies aim to promote adaptive circuit changes after neurological disease or injury, but insufficient or maladaptive plasticity often prevents a full recovery. The development of adjunctive strategies that broadly support plasticity to facilitate the benefits of rehabilitative interventions has the potential to improve treatment of a wide range of neurological disorders. Recently, stimulation of the vagus nerve in conjunction with rehabilitation has emerged as one such potential targeted plasticity therapy. Vagus nerve stimulation (VNS) drives activation of neuromodulatory nuclei that are associated with plasticity, including the cholinergic basal forebrain and the noradrenergic locus coeruleus. Repeatedly pairing brief bursts of VNS sensory or motor events drives robust, event-specific plasticity in neural circuits. Animal models of chronic tinnitus, ischemic stroke, intracerebral hemorrhage, traumatic brain injury, and post-traumatic stress disorder benefit from delivery of VNS paired with successful trials during rehabilitative training. Moreover, mounting evidence from pilot clinical trials provides an initial indication that VNS-based targeted plasticity therapies may be effective in patients with neurological diseases and injuries. Here, I provide a discussion of the current uses and potential future applications of VNS-based targeted plasticity therapies in animal models and patients, and outline challenges for clinical implementation.

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“…This subacute recovery in motor function can be explained in part by neural reorganization caused by rehabilitation training [8][9][10][11][12]. It is suggested that key factors to upperlimb stroke rehabilitation training are attention, repetition, intensity of practice, reward, progression of complexity, and skill acquisition and that this training should be task-oriented [12][13].…”

Section: Introductionmentioning

confidence: 99%

Participant perceptions of use of CyWee Z as adjunct to rehabilitation of upper-limb function following stroke

Hale

Satherley

McMillan

et al. 2012

JRRD

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Abstract-This article reports on the perceptions of 14 adults with chronic stroke who participated in a pilot study to determine the utility, acceptability, and potential efficacy of using an adapted CyWee Z handheld game controller to play a variety of computer games aimed at improving upper-limb function. Four qualitative in-depth interviews and two focus groups explored participant perceptions. Data were thematically analyzed with the general inductive approach. Participants enjoyed playing the computer games with the technology. The perceived benefits included improved upper-limb function, concentration, and balance; however, six participants reported shoulder and/or arm pain or discomfort, which presented while they were engaged in play but appeared to ease during rest. Participants suggested changes to the games and provided opinions on the use of computer games in rehabilitation. Using an adapted CyWee Z controller and computer games in upper-limb rehabilitation for people with chronic stroke is an acceptable and potentially beneficial adjunct to rehabilitation. The development of shoulder pain was a negative side effect for some participants and requires further investigation.

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Plasticity of the human motor cortex and recovery from stroke

Cited by 319 publications

References 64 publications

Non-Invasive Brain Stimulation Improves Paretic Limb Force Production: A Systematic Review and Meta-Analysis

Non-Invasive Brain Stimulation Improves Paretic Limb Force Production: A Systematic Review and Meta-Analysis

Enhancing Rehabilitative Therapies with Vagus Nerve Stimulation

Participant perceptions of use of CyWee Z as adjunct to rehabilitation of upper-limb function following stroke

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