Plasticizers in Transdermal Drug Delivery Systems

Güngör, Sevgi; Erdal, Meryem Sedef; Özsoy, Yıldız

doi:10.5772/38156

Cited by 27 publications

(32 citation statements)

References 44 publications

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“…Films intended for transdermal drug delivery must be flexible enough to follow the movements of the skin (18,22). It has been reported that an ideal transdermal film should be soft and tough that can be characterized by a high elongation value (23,24). According to our presented results, the control transdermal film (TF-CONT) exhibited a significantly lower flexibility compared to other transdermal films containing of dl-limonene (p<0.05).…”

Section: Resultsmentioning

confidence: 46%

“…They soften the rigidity of the film structure by increasing the mobility of the polymer chains and improve the mechanical characteristics of the resulted films (23,24). Also, it has been found that the effect of the plasticizer on drug transport is related to the physicochemical properties of the permeant, in particular to its solubility in the plasticizer (30).…”

Section: Resultsmentioning

confidence: 99%

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Biopolymer-Based Transdermal Films of Donepezil as an Alternative Delivery Approach in Alzheimer’s Disease Treatment

2014

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Abstract. Matrix type transdermal films of donepezil (DNP) as an alternative delivery approach was designed to improve patient compliance to Alzheimer disease treatment. Sodium alginate, a natural polysaccharide, was used as matrix-forming agent in the optimization of transdermal films. Propylene glycol and dl-limonene was added into films as a plasticizer and permeation enhancer, respectively. As well as mechanical strength and bioadhesiveness of optimized transdermal films of DNP, the impact of dl-limonene concentration in films on DNP in vitro permeation across pig skin was assessed. Attenuated total reflectance-Fourier transform infrared (ATR-FTIR) measurements were carried out to examine the effects of enhancer on in vitro conformational order of the stratum corneum intercellular lipids following permeation study. Results showed that transdermal formulations of DNP were suitable due to both mechanical and bioadhesive features of the films. In vitro skin permeation study indicated that dl-limonene at a concentration of 3% was optimum with high drug flux. ATR-FTIR results confirmed a more fluidized stratum corneum lipid state in the presence of dl-limonene, indicating its permeation enhancement effect. Regarding to achieve therapeutic levels of DNP, it seems to be feasible deliver DNP with transdermal films for the management of Alzheimer disease.

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Section: Resultsmentioning

confidence: 46%

Section: Resultsmentioning

confidence: 99%

Biopolymer-Based Transdermal Films of Donepezil as an Alternative Delivery Approach in Alzheimer’s Disease Treatment

2014

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“…A solvent can exert a plasticizing effect on a polymer (Güngör et al, 2012) which could increase the diffusion rate of a drug within a polymer film (Siepmann et al, 1999). Any residual solvent may also be released from the matrix and taken-up by the skin after application of the TTS and have there a permeation enhancing effect (Chattaraj and Walker, 1995).…”

Section: Introductionmentioning

confidence: 98%

Effect of residual solvent in polymer adhesive matrix on release and skin permeation of scopolamine

Kunst

Lee

2015

International Journal of Pharmaceutics

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“…The addition of a plasticizer to a polymer results an increase in molecular motion so that drug molecules can diffuse through the plasticized polymer matrix at a higher rate [7,42]. In pre-formulation studies we observed that the unplasticized sodium alginate films were non-flexible (data not given).…”

Section: Code Hardness (N) Elasticity (Mj) Cohesiveness Adhesiveness mentioning

confidence: 82%

“…The A plasticizer is added to a polymer formulation to enhance its flexibility and to help its processing [42]. The addition of a plasticizer to a polymer results an increase in molecular motion so that drug molecules can diffuse through the plasticized polymer matrix at a higher rate [7,42].…”

Section: Code Hardness (N) Elasticity (Mj) Cohesiveness Adhesiveness mentioning

confidence: 99%

Optimization of Biopolymer Based Transdermal Films of Metoclopramide as an Alternative Delivery Approach

et al. 2014

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Abstract:The objectives of this study were to develop and to characterize sodium alginate based matrix-type transdermal films of metoclopramide hydrochloride (MTC) in order to improve patient compliance to treatment. The suitability of sodium alginate was shown to be a natural film former in terms of the physicochemical, mechanical, and bioadhesive features of the MTC loaded transdermal films. Terpinolene provided the highest drug release among the different terpenes (nerolidol, eucalyptol, dl-limonene, or terpinolene) assessed as enhancer. Attenuated Total Reflectance Infrared (ATR-FTIR) spectroscopy analysis performed to evaluate the effect of the transdermal films on skin barrier confirmed enhancer induced lipid bilayer disruption in stratum corneum, indicating its permeation enhancement effect.

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Plasticizers in Transdermal Drug Delivery Systems

Cited by 27 publications

References 44 publications

Biopolymer-Based Transdermal Films of Donepezil as an Alternative Delivery Approach in Alzheimer’s Disease Treatment

Biopolymer-Based Transdermal Films of Donepezil as an Alternative Delivery Approach in Alzheimer’s Disease Treatment

Effect of residual solvent in polymer adhesive matrix on release and skin permeation of scopolamine

Optimization of Biopolymer Based Transdermal Films of Metoclopramide as an Alternative Delivery Approach

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