'Plate‐like‐coral' polymer particles with dendritic structure and porous channels: Effective delivery of anti‐cancer drugs

Abstract

'Plate‐like‐coral' shaped polymer capsule (PC‐PLCDB) with dendritic network structure and porous channels has been synthesized and used for therapeutic purposes. First di‐block copolymer [(PEG)‐b‐(L‐AspA)n] has been synthesized from PEG (polyethylene glycol) and aspartic acid (AspA). Then the biocompatible PC‐PLCDB has been achieved by homogeneous mixing of [(PEG)‐b‐(L‐AspA)n] and poly‐N‐isopropyl acrylamide (PNIPAM) followed by reprecipitation. Only H‐bonding is responsible for the foundation of self‐assembly of the polymer chains and to form PC‐PLCDB. A huge extent of loading anticancer drug, for example, doxorubicin (DOX) in PC‐PLCDB is possible. in vitro study has been performed to check the therapeutic efficacy of PC‐PLCAD‐DOX formulation on chronic myeloid leukemia cells (K562). The IC50 has been calculated to be 0.405 (±0.014) ng μg−1 of the formulation. PC‐PLCAD‐DOX inhibits 80% of the cancer cell only by 1.0 μg mL−1 of the formulation. This study reveals that the PC‐PLCAD could be a promising candidate for therapeutic applications.

Secondary Structures in Synthetic Poly(Amino Acids): Homo‐ and Copolymers of Poly(Aib), Poly(Glu), and Poly(Asp)

“…Especially, hybrid-polymers consisting of PAsp n and poly(ethylene glycol) attracted a lot of attention as carrier for anti-cancer drugs. [106][107][108][109] These two types of peptides show good solubility in organic solvents, the possibility to convert them into water-soluble polypeptides by removal of the side chain protection groups [110] and a dynamic behavior in their secondary structure formation. Although these two types of poly(amino acids) usually adopt the right-handed 𝛼-helix (𝛼 r )-helix, the final conformation strongly depends on chemical and physical conditions introduced to the system such as molecular weight, the used solvent, end group, temperature or substitution of the side chain benzyl-group.…”