Platelet 5-hydroxytryptamine accumulation in depressive illness

Coppen, Alec; Swade, Cynthia; Wood, Keith

doi:10.1016/0009-8981(78)90071-2

Cited by 198 publications

(29 citation statements)

References 10 publications

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“…This observation is in ac cordance with results given in other studies [Hallstrom et al. 1976;Coppen et al, 1978;Toumisto et al. 1979;Ehsanullah et al, 1980;Meltzer et al, 1981], It is noteworthy that in the present study the decreased platelet 5HT uptake was more pronounced in the pres ence of high concentrations of 5HT (5 X 10-6 and 1 X 10-5A0 which express the maximum velocity (Vmax).…”

Section: Discussionsupporting

confidence: 81%

“…This phenomenon was observed in endogenous depression [Toumisto et al, 1979] and unipolar depression [Coppen et al, 1978].…”

Section: Introductionmentioning

confidence: 92%

“…In several studies [Hallstrom et al, 1976;Toumisto et al" 1979;Ehsanullah, 1980;Coppen et al, 1978] it was shown that blood platelets of depressed patients have a decreased active transport of 5HT. This phenomenon was observed in endogenous depression [Toumisto et al, 1979] and unipolar depression [Coppen et al, 1978].…”

Section: Introductionmentioning

confidence: 99%

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5-Hydroxytryptamine Uptake by Blood Platelets of Unipolar and Bipolar Depressed Patients

Modai¹,

Zemishlany²,

Jerushalmy³

1984

Neuropsychobiology

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The active transport of 5-hydroxytryptamine (5HT) by blood platelets of unipolar and bipolar depressed patients was determined. The 5HT uptake by platelets of bipolar patients was determined in depressive, euthymic and manic states. The 5HT uptake was always followed by studying platelets of healthy individuals of the same sex and age. The results confirm the known fact that there is a decreased 5HT active transport in platelets of unipolar depressed patients. On the other hand, the amount of 5HT transported by platelets of bipolar depressed patients was higher than that observed in platelets of healthy individuals. In manic and euthymic bipolar patients the uptake was similar to their matched controls.

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Section: Discussionsupporting

confidence: 81%

“…This phenomenon was observed in endogenous depression [Toumisto et al, 1979] and unipolar depression [Coppen et al, 1978].…”

Section: Introductionmentioning

confidence: 92%

See 1 more Smart Citation

5-Hydroxytryptamine Uptake by Blood Platelets of Unipolar and Bipolar Depressed Patients

Modai¹,

Zemishlany²,

Jerushalmy³

1984

Neuropsychobiology

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“…We therefore confirm the results of Tuomisto & Tukiainen (1976) and Coppen et al (1978) which showed a decreased accumulation of 5-HT in platelets from depressed patients, and, in addition, we present results of a decreased accumulation of DA in these patients, suggesting an involvement of both amines in depression.…”

supporting

confidence: 92%

Decreased uptake of 5‐hydroxytryptamine and dopamine into blood platelets from depressed patients [proceedings]

Ehsanullah¹,

Mulgirigama²

1979

Brit J Clinical Pharma

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“…The method of determination of platelet 5-HT uptake characteristics was the same for all subjects studied, and was similar to that described previously (Coppen et al, 1978).…”

mentioning

confidence: 99%