Platelet Activation in Obese Women

Davı̀, Giovanni; Guagnano, Maria Teresa; Ciabattoni, Giovanni; Basili, Stefania; Falco, Angela; Marinopiccoli, Marina; Nutini, Michele; Sensi, S; Patrono, Carlo

doi:10.1001/jama.288.16.2008

Cited by 499 publications

(106 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This difference is consistent with other reports of a sex difference in brain reserve and clinical manifestations of AD pathologic changes, 19–21 although this association remains a point of discussion. Importantly our results also showed that both smoking and increased BMI, already know to be associated with increased free radical injury in peripheral organs, 22,23 were also associated with increased CSF F 2 -isoprostanes. Thus avoidance of smoking and reducing BMI, in addition to their already established benefits, may also be beneficial in reducing molecular and cellular stress to our brains.…”

Section: Discussionsupporting

confidence: 78%

Influence of Lifestyle Modifications on Age-Related Free Radical Injury to Brain

Peskind

Shofer

et al. 2014

JAMA Neurol

View full text Add to dashboard Cite

[2013][2014][2015][2016][2017][2018] seeks to optimize brain health as we age. Free radical injury is an important effector of molecular and cellular stress in the aging brain that derives from multiple sources.OBJECTIVE To identify potentially modifiable risk factors associated with increased markers of brain oxidative stress. DESIGN, SETTING, AND PARTICIPANTSThis cross-sectional, academic multicenter study consisted of 320 research volunteers (172 women) aged 21 to 100 years who were medically healthy and cognitively normal. MAIN OUTCOMES AND MEASURESFree radical injury to the brain was assessed using cerebrospinal fluid (CSF) F 2 -isoprostane (F 2 -IsoP) concentrations correlated with age, sex, race, cigarette smoking, body mass index, inheritance of the ε4 allele of the apolipoprotein E gene (APOE), and CSF biomarkers of Alzheimer disease. RESULTSThe concentration of CSF F 2 -IsoP increased with age by approximately 3 pg/mL (approximately 10%) from age 45 to 71 years in medically healthy, cognitively normal adults (P < .001). The CSF F 2 -IsoP concentration increased by approximately more than 10% for every 5-U increase in body mass index (P < .001). Current smoking had an approximately 3-fold greater effect on CSF F 2 -IsoPs compared with age (P < .001). Women had greater mean CSF F 2 -IsoP concentrations than men at all ages after adjusting for other factors (P = .02). Neither the concentration of CSF Alzheimer disease biomarkers nor inheritance of the APOE ε4 allele was associated with the CSF F 2 -IsoP concentration in this group of medically healthy, cognitively normal adults (P > .05). The association between CSF F 2 -IsoP concentrations and race was not significant after controlling for the effect of current smoking status (P = .45). CONCLUSIONS AND RELEVANCEOur results are consistent with an age-related increase in free radical injury in the human brain and uniquely suggest that this form of injury may be greater in women than in men. Our results also highlighted 2 lifestyle modifications (ie, body mass index and smoking) that would have an even greater effect on suppressing free radical injury to the brain than would suppressing the processes of aging. These results inform efforts to achieve success in the Healthy Brain Initiative 2013-2018.

show abstract

Section: Discussionsupporting

confidence: 78%

Influence of Lifestyle Modifications on Age-Related Free Radical Injury to Brain

Peskind

Shofer

et al. 2014

JAMA Neurol

View full text Add to dashboard Cite

show abstract

“…MetS and diabetes mellitus are well known causes of CVD. In addition, obesity by itself is related to atherosclerosis, hypertension and prothrombotic complications (22,23). Many studies have shown that LDL is increased in women with PCOS (24).…”

Section: Discussionmentioning

confidence: 99%

Subclinical left ventricular dysfunction in women with polycystic ovary syndrome: an observational study

Erdoğan

Akkaya²,

Bacaksız³

et al. 2013

Anadolu Kardiyol Derg

View full text Add to dashboard Cite

Objective: Cardiac involvement has been increasingly recognized in patients with polycystic ovary syndrome (PCOS). Identification of the earliest asymptomatic impairment of left ventricular (LV) performance may be important in preventing progression to overt heart failure. Our aim was to investigate LV function with different echocardiographic techniques in patients with PCOS. Methods: Thirty patients with PCOS and 30 age and body mass index matched healthy subjects were enrolled to this cross-sectional observational study. All subjects underwent echocardiography for assessment of resting LV function as well as two-dimensional speckle tracking echocardiography (2D-STE) and real-time three-dimensional echocardiography (3D-Echo). Global longitudinal strain (GLS) was calculated from 3 standard apical views using 2D-STE. Student t-test, Chi-square test, Pearson's, and Spearman's correlation analysis were used for statistical analysis. Results: The early mitral inflow deceleration time (DT), isovolumetric relaxation time (IVRT) and E/Em ratio were increased in the PCOS group (p<0.05 for all). Waist-to-hip ratio, fasting insulin, homeostasis model assessment of insulin resistance (HOMA-IR) and low-density lipoprotein (LDL) levels were higher in PCOS group (p<0.05 for all). Significant correlation was observed between DT, IVRT and insulin value, HOMA-IR (p<0.05 for all). On 3D-Echo evaluation, none of the patients in both groups had LV systolic dysfunction with comparable LV ejection fraction and LV volumes. 2D-STE showed that GLS was significantly reduced in the PCOS group compared to control group (-16.78±0.56% vs. -18.36±1.04%, p<0.001). The GLS was found to be negatively correlated with waist-to-hip ratio and LDL values (p<0.05 for all). Conclusion: These results indicate that PCOS may be related to impaired LV systolic function detected by 2D-STE. In addition, PCOS may lead to diastolic dysfunction. Reduced GLS might be an early indicator of cardiac involvement in this patient population. Original Investigation Özgün Araşt›rma 784ÖZET Amaç: Polikistik over sendromlu (PKOS) hastalarda kardiyak tutulumun olduğu kabul edilmektedir. Asemptomatik sol ventrikül (SV) fonksiyonlarındaki bozulmanın erken tespiti kalp yetersizliğine gidişatın önlenmesinde önemli olabilir. Amacımız PKOS hastalarında farklı ekokardiyografik teknikler kullanarak SV fonksiyonlarını araştırmaktır. Yöntemler: Kesitsel ve gözlemsel calışmamıza, polikistik over sendromlu 30 hasta ve demografik özellikleri benzer 30 sağlıklı kadın dahil edildi. İstirahat SV fonksiyonlarının değerlendirilmesinde standart transtorasik ekokardiyografi yanında, iki boyutlu benek izleme ekokardiyografi (2B-BIE) ve üç boyutlu ekokardiyografi (3B-Eko) bakıldı. SV hacimleri ve ejeksiyon fraksiyonu ölçümü 3B-Eko ile yapıldı. Apikal görüntülerden 2B-BIE tekniği kullanılarak global longitüdinal strain (GLS) değerleri hesaplandı. İstatistiksel analizde; Student t-testi, Ki-kare testi, Pearson ve Spearman korelasyon analizleri kullanıldı. Bulgular: Polikistik over sendr...

show abstract

“…Both obesity and diabetes have been shown to be associated with oxidative stress [75][76][77][78] and inflammation [79][80][81][82][83]. The concentration of pro-inflammatory cytokines including TNF is elevated in T2D [81] and may contribute to HH in this condition.…”

Section: E) Role Of Inflammationmentioning

confidence: 99%

Hypogonadotrophic Hypogonadism in Type 2 Diabetes, Obesity and the Metabolic Syndrome

Dandona¹,

Dhindsa²,

Chaudhuri³

et al. 2008

CMM

View full text Add to dashboard Cite

Recent work shows a high prevalence of low testosterone and inappropriately low LH and FSH concentrations in type 2 diabetes. This syndrome of hypogonadotrophic hypogonadism (HH) is associated with obesity, and other features of the metabolic syndrome (obesity and overweight, hypertension and hyperlipidemia) in patients with type 2 diabetes. However, the duration of diabetes or HbA1c were not related to HH. Furthermore, recent data show that HH is also observed frequently in patients with the metabolic syndrome without diabetes but is not associated with type 1 diabetes. Thus, HH appears be related to the two major conditions associated with insulin resistance: type 2 diabetes and the metabolic syndrome. CRP concentrations have been shown to be elevated in patients with HH and are inversely related to plasma testosterone concentrations. This inverse relationship between plasma free testosterone and CRP concentrations in patients with type 2 diabetes suggests that inflammation may play an important role in the pathogenesis of this syndrome. This is of interest since inflammatory mechanisms may have a cardinal role in the pathogenesis of insulin resistance. It is relevant that in the mouse, deletion of the insulin receptor in neurons leads to HH in addition to a state of systemic insulin resistance. It has also been shown that insulin facilitates the secretion of gonadotrophin releasing hormone (GnRH) from neuronal cell cultures. Thus, HH may be the result of insulin resistance at the level of the GnRH secreting neuron. Low testosterone concentrations in type 2 diabetic men have also been related to a significantly lower hematocrit and thus to an increased frequency of mild anemia. Low testosterone concentrations are also related to an increase in total and regional adiposity, and to lower bone density. This review discusses these issues and attempts to make the syndrome relevant as a clinical entity. Clinical trials are required to determine whether testosterone replacement alleviates symptoms related to sexual dysfunction, and features of the metabolic syndrome, insulin resistance and inflammation.

show abstract

Platelet Activation in Obese Women

Abstract: Android obesity is associated with enhanced lipid peroxidation and persistent platelet activation. These abnormalities are driven by inflammatory triggers related to the degree of abdominal adiposity and are, at least in part, reversible with a successful weight-loss program.

Cited by 499 publications

References 46 publications

Influence of Lifestyle Modifications on Age-Related Free Radical Injury to Brain

Influence of Lifestyle Modifications on Age-Related Free Radical Injury to Brain

Subclinical left ventricular dysfunction in women with polycystic ovary syndrome: an observational study

Hypogonadotrophic Hypogonadism in Type 2 Diabetes, Obesity and the Metabolic Syndrome

Contact Info

Product

Resources

About