Platelet adhesive resistance of segmented polyurethane film surface-grafted with vinyl benzyl sulfo monomer of ammonium zwitterions

Structures and Synthesis of Zwitterionic Polymers

“…In particular, the latter profits from the facile incorporation of reactive groups in special positions, e.g., in the center or at the ends of the polymers, that enable efficient attachment of the macromolecules onto the substrates. Still, classical grafting-from [318][319][320][321][322][323][324][325][326][327][328][329][330][331][332][333][334][335], grafting-to [336][337][338][339][340][341][342][343][344][345][346], and grafting-through [316,347] procedures are of course continuously in use, especially in industrial applications, where the activation of the surfaces for the grafting process by physical means or by simple, "unpretentious" chemistry is preferred for reasons of experience, cost and high-throughput.…”

Grafting of zwitterion from polysulfone membrane via surface-initiated ATRP with enhanced antifouling property and biocompatibility

“…Furthermore, to improve antifouling property and biocompatibility of membranes, several polymers were used for surface modification over the past two decades, such as heparin [15][16][17][18][19], heparin-like polymers [20][21][22][23][24], PEG [6,8,9,25,26], phospholipid polymers [3][4][5][27][28][29] and zwitterionic polymers [7,[30][31][32][33][34][35][36][37][38][39][40], and so on. It was reported that the polymers with zwitterionic structures (sulfobetaine and carboxybetaine) could maintain normal conformation of biomacromolecules and improve biocompatibility [30,34].…”

Molecular dynamics simulation study on zwitterionic structure to maintain the normal conformations of Glutathione

“…The hypothesis of "maintain of normal structure" predicted theoretically that zwitterionic structure should behave well in anticoagulation through maintaining the normal structure of contacting proteins. While recent experimental studies on surface-grafted zwitterionic biomaterials have proved good blood compatibility [3][4][5] , the validity of this hypothesis still waits to be testified from the interactions between zwitterionic surface and proteins on the sub-molecular level. Molecular dynamics simulation using empirical force fields provides one of the most direct methods of theoretically investigating the behaviors of complex molecular systems and is well-suited for the simulation of protein-surface interactions.…”