Platelet Antiaggregant Methoxyphenylthienyl Ketoxime Ethers: Synthesis and Structure‐Activity Relationships

Varache‐Lembege, Martine; Nuhrich, A.; Renard, Pierre; Duboudin, F.; Vercauteren, Joseph; Devaux, G.

doi:10.1002/ardp.19953280505

Cited by 7 publications

(5 citation statements)

References 12 publications

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“…Blocking MAO-A is used in the treatment of depression and anxiety, and MAO-B in the treatment of Parkinson's disease and AD. Min Oh et al [100], considering that oxime ethers have a wide range of biological activities, and ethyl acetohydroxamate chalcones inhibit MAO-B and acetylcholinesterase (AChE), studied 24 new chalcone oxime ethers (99). The vast majority of these compounds showed selective MAO-B inhibition.…”

Section: Compounds With Monoamine Oxidase (Mao) and Acetylcholinester...mentioning

confidence: 99%

“…Varache-Lembege et al [ 99 ] synthesized methoxyphenyl thienyl ketoxime ethers and studied their inhibitory effect on platelet aggregation induced by arachidonic acid (AA). Compounds (Z)- 98a and (Z)- 98b (IC 50 = 55 mM) was four times more active than acetylsalicylic acid (ASA) (IC 50 = 225 mM).…”

Section: Oxime Ethers With Other Biological Activitiesmentioning

confidence: 99%

“…The ( Z )-isomer of oxime ether 98c (IC 50 = 110 µM) was twice as strong as ASA. Derivatives containing a methoxy group in the ortho and meta position were much less active, while the ( E ) isomers were characterized by much weaker anti-aggregation properties compared to the ( Z ) isomers [ 99 ].…”

Section: Oxime Ethers With Other Biological Activitiesmentioning

confidence: 99%

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A Review of Biologically Active Oxime Ethers

et al. 2023

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Oxime ethers are a class of compounds containing the >C=N-O-R moiety. The presence of this moiety affects the biological activity of the compounds. In this review, the structures of oxime ethers with specific biological activity have been collected and presented, and bactericidal, fungicidal, antidepressant, anticancer and herbicidal activities, among others, are described. The review includes both those substances that are currently used as drugs (e.g., fluvoxamine, mayzent, ridogrel, oxiconazole), as well as non-drug structures for which various biological activity studies have been conducted. To the best of our knowledge, this is the first review of the biological activity of compounds containing such a moiety. The authors hope that this review will inspire scientists to take a greater interest in this group of compounds, as it constitutes an interesting research area.

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Section: Compounds With Monoamine Oxidase (Mao) and Acetylcholinester...mentioning

confidence: 99%

Section: Oxime Ethers With Other Biological Activitiesmentioning

confidence: 99%

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A Review of Biologically Active Oxime Ethers

et al. 2023

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“…They are used in organic synthesis, providing valuable reagentst oo btain cis-1.2-aminoalcohols, [1] hydroxyloamines, [2] enantioselectives ynthesis of the amines, [3] and,u nder specific conditions in cyclization reactions, can lead to the formation of substituted heteroaromatic compounds. [4,5] However,m any oxime ethers are applicable as specifiedc ompounds with biological activity.T hey exhibit anticancer, [6] anti-aggregation, [7] antidepressant, [8,9] anticonvulsant, [10] antimicrobial, [11] antiviral, [12] acaricidal, [13] anti-protozoal, [14] and herbicidal [15] effects. There has also been research performed on the use of oxime ethers as fragrances.…”

Section: Introductionmentioning

confidence: 99%

“…However, many oxime ethers are applicable as specified compounds with biological activity. They exhibit anticancer, anti‐aggregation, antidepressant, anticonvulsant, antimicrobial, antiviral, acaricidal, anti‐protozoal, and herbicidal effects. There has also been research performed on the use of oxime ethers as fragrances …”

Section: Introductionmentioning

confidence: 99%

Study of the Room‐Temperature Synthesis of Oxime Ethers by using a Super Base

et al. 2018

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In this study, we present a convenient method for the synthesis of oxime ethers by reacting oximes with various chlorides (alkyl, functionalized alkyl, and benzyl) and with the subsequent use of a super base—pulverized potassium hydroxide in DMSO. The reactions take place at room temperature and the products are obtained in high yields. The final products were received within 2 min to 3 h. In addition, the compounds do not require chromatographic separation. The structure elucidation of the titled compounds was performed by using 1H NMR and 13C NMR spectroscopy as well as mass spectrometry. The presented method of synthesis for oxime ethers is environmentally friendly, because neither water cooling or heating of the reaction mixture/solvents (necessary for chromatographic purification) is required. The synthesis can be carried out very easily on a large scale.

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Investigation of radiation-grafted and radiation-modifiedN-vinyl-2-pyrrolidone onto polypropylene film

Al‐Sagheer

El‐Sawy

2000

J. Appl. Polym. Sci.

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The radiation‐induced graft copolymerization of N‐vinyl‐2‐pyrrolidone (NVP) onto polypropylene films was investigated using the mutual method. The grafted polymer was modified with prepared α,β‐unsaturated nitrile (Scheme ). The water uptake of the grafted and modified grafted films was found to increase with the degree of grafting. It was observed that the swelling behavior of the modified grafted films with α‐cyano‐β‐phenyl crotononitrile improved more than that of the film grafted and modified grafted with α‐cyano‐β‐(2‐thienyl)crotononitrile or α‐cyano‐β‐(2‐pyridyl)crotononitrile. The modification process for the grafted substrate was confirmed by IR spectroscopy. No significant improvement was observed in thermal stability for the modified grafted films compared to the grafted films. Scanning electron microscopy (SEM) of the grafted and modified grafted membranes heated to 150°C showed change in the structure and morphology. Improvement in the hydrophilicity and morphology of these membranes with carbonitriles may increase the permeability of those membranes for some practical applications.

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Platelet Antiaggregant Methoxyphenylthienyl Ketoxime Ethers: Synthesis and Structure‐Activity Relationships

Cited by 7 publications

References 12 publications

A Review of Biologically Active Oxime Ethers

A Review of Biologically Active Oxime Ethers

Study of the Room‐Temperature Synthesis of Oxime Ethers by using a Super Base

Investigation of radiation-grafted and radiation-modifiedN-vinyl-2-pyrrolidone onto polypropylene film

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