“Platelet-associated regulatory system (PARS)” with particular reference to female reproduction

Bódis, József; Papp, S; Vermes, I.; Sulyok, E.; Tamás, Péter; Farkas, Bálint; Zámbó, Katalin; Hatzipetros, Ioannis; Kovaćs, Gábor L.

doi:10.1186/1757-2215-7-55

Cited by 18 publications

(32 citation statements)

References 90 publications

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“…However, the role of platelets in the female reproductive system is gaining more attention [22]. Aside from their essential role in hemostasis, thrombosis, and coagulation, platelets are now known to be involved in inflammation, neoplasia, and immune regulation [23].…”

Section: Discussionmentioning

confidence: 99%

Activated Platelets Induce Estrogen Receptor β Expression in Endometriotic Stromal Cells

Zhang

Ding²,

Liu³

et al. 2015

Gynecol Obstet Invest

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Background/Aims: Endometriosis is viewed first and foremost as an estrogen-dependent disease, featuring not only excessive estrogen production but also aberrant expression of estrogen receptors (ERs), particularly ERβ, that mediate the estrogen action. ERβ is the predominant ER in mediating estrogen action in endometriosis, and estrogen plays a vital role in the development of endometriosis; thus, ERβ is viewed as a strong candidate for therapeutic targeting. Given our recent finding that platelets aggregate in endometriotic lesions, we sought to investigate whether activated platelets can upregulate ERβ. Methods: Using primary endometriotic stromal cells derived from patients with ovarian endometriomas and platelets harvested from healthy donors, we performed real-time RT-PCR analysis of mRNA abundance (n = 8) and Western blot analysis of protein expression (n = 8) of ERα and ERβ when co-cultured with phosphate-buffered saline, platelets, thrombin alone, and platelets plus thrombin for 48 h. Results: Treatment of endometriotic stromal cells with activated platelets resulted in the upregulation of ERβ gene and protein expression. Conclusion: In the presence of aggregated and thus activated platelets in endometriotic lesions, ERβ, but not ERα, is upregulated in endometriotic stromal cells. Our result suggests that the use of antiplatelet therapy may have potential in the treatment of endometriosis.

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Section: Discussionmentioning

confidence: 99%

Activated Platelets Induce Estrogen Receptor β Expression in Endometriotic Stromal Cells

Zhang

Ding²,

Liu³

et al. 2015

Gynecol Obstet Invest

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“…Значение тромбоцитов в реализации менструального цикла только начинает активно изучаться, но то, что уже известно, позволило J. Bódis и соавт. [30] назвать тромбоциты корпускулярными мессенджерами, способными модулировать функцию гипоталамо-гипофизарно-яичниковой системы. Этой группой ученых проведена серия исследований по изучению взаимосвязи между процессом созревания доминантного фолликула с последующей овуляцией и состоянием тромбоцитарного гемостаза.…”

Section: The Role Of Platelets In Female Reproductive Functionunclassified

The role of platelets in female reproductive function

Yashchuk¹,

Maslennikov²,

Dautova³

et al. 2017

Ross. vestn. akush.-ginekol.

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Система гемостаза как фактор, лимитирующий процесс успешной реализации репродуктивной функции человека, привлекает все большее внимание представителей медицинской науки и практики [1-5]. Во многих отечественных и зарубежных изданиях [6-12] подробно описана кинетика гемостатических реакций тромбоцита, изучены особенности трансформации сосудисто-тромбоцитарного гемостаза (СТГ) в зависимости от фазы менструального цикла, во время беременности и в послеродовом периоде. Между тем большинство исследователей [13-15] при изучении гемостаза делают акцент на тромбоэмболических осложнениях и акушерских кровотечениях. С данных позиций первичный гемостаз зачастую рассматривается лишь как частный компонент системы регуляции агрегатного состояния крови [16-18], в то время как роль

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“…Hence, platelets are corpuscular transmitters much more than participants in the process of hemostasis [24,25] …”

Section: Role Of Platelets In the Regulation Of The Female Reproductimentioning

confidence: 99%

“…Trophoblastic cells demonstrate the ability of activating coagulation in the vascular bed of the placenta. Another way of platelet reaction is immunomodulatory platelet-type complement activation via P-selectin receptor Par4 [15,24]. Immunohistochemical staining with antibodies to P-seletin demonstrated the presence of activated platelets in the decidua, in the area of maternal origin between the trophoblastic cells of the placenta and in spiral arteries [15,24].…”

Section: Role Of Platelets In Pregnancy (Implantation Placentation)mentioning

confidence: 99%

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Platelets (thrombocytes): The other recognized functions

Nikolić¹,

Vukovic-Suvajdzic²,

Bugarinovic³

et al. 2016

Hosp Pharm Int Multi J

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SUMMARYIntroduction: Platelets are smallest blood cells of discoid or round shape and are cytoplasmic fragments of megakaryocytes.Platelets consist of 3 types of granules: alpha granules, dense granules and lysosomes. Granule secretion releases coagulation factors, growth factors, cytokines, and a number of proteolytic enzymes.Platelets contain a number of receptors known as platelet agonists. Basic and most studied role of platelets is in hemostasis process. The aim of this paper is to point on platelet function unrelated to hemostasis. Matherials and methoods: Papers on other recognized functions of platelets were searched for in biomedical journals idexed in MEDLINE form 2004 to 2016. Topic: This paper studies less known platelet functions becoming subject of interest with the development of applied science. Platelets participate in infl ammation by releasing proinfl ammatory mediators (CD154, CD40L). Complement activation via Pselectin, platelet-generates immunomodulatory eff ect. CD40L accelerates releasing RANTES protein leading to intensifi ed activation of T-lymphocytes. During embryonic development, platelets allow blood and lymph vessels separation by activating CLE-2 receptor and ligand PDPN. Platelets alleviate migration and invasiveness of tumor cells, contribute to disease progression and development of metastases. Platelets affect maturation of follicles and oocytes and have important role in embryo implantation process and placentation. Conclusion: Based on these fi ndings, conclusion imposes platelets as not only active participants in the hemostasis process but as having signifi cant role in infl ammation, unspecifi ed and specifi ed body defending, tumor biology, embryonic development and in female reproductive system regulation. Numerous roles of platelets open wide range for the new drugs' operation. Their specifi c characteristic is the basis for the personalized Clinical pharmacology development and possibility of applying specifi c drug as polyindicative therapeutic agent.

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“Platelet-associated regulatory system (PARS)” with particular reference to female reproduction

Cited by 18 publications

References 90 publications

Activated Platelets Induce Estrogen Receptor β Expression in Endometriotic Stromal Cells

Activated Platelets Induce Estrogen Receptor β Expression in Endometriotic Stromal Cells

The role of platelets in female reproductive function

Platelets (thrombocytes): The other recognized functions

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