Platelet biology and the rationale of PRP therapy in chronic wounds

Rainys, Domantas; Samulėnas, Gediminas; Kievišas, Mantas; Samulėnienė, Eglė; Pilipaitytė, Loreta; Rimdeika, Rytis

doi:10.1007/s00238-017-1279-x

Cited by 10 publications

(5 citation statements)

References 66 publications

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“…Plasma Rich Platelets (PRP) is obtained from autologous blood that contains different growth factors that may act on tissues involved in the wound healing and regeneration (3) . Activation of platelet poor plasma (PPP) by thermal measures and /or, adding an activator gives rise to a gelatinous material formation, which is known as plasma filler.…”

Section: Figure (2)mentioning

confidence: 99%

“…or P.P.P., and gelled proteins that provide constant stability and volume (5) . In other words plasma gel is simply a gelatinous form of PRP containing all the growth factors of ordinary PRP and PPP but with a longer duration inside the tissues (3) . The gel formula serves to stop the diffusion of both activated platelets and their pre synthesized growth factors in the treatment area and sustain their therapeutic effects for several months after the last treatment injection (6) .…”

Section: Figure (2)mentioning

confidence: 99%

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Comparison between Plasma gel (Filler) and Polydiaxone (PDO) Threads in Treating Fine and Medium Sized Infra-Orbital Wrinkles Using 3D Antera Camera

Hassen¹,

Diab²,

Zayed³

et al. 2023

The Egyptian Journal of Hospital Medicine

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Background: Plasma gel is a new procedure in the aesthetic field. It has been used for various dermatological conditions including wound healing, anti-inflammatory, and cosmetic uses. Infra-orbital dark circles possess no medical harm but signifies cosmetic and psychological burden. Objective: Evaluation the efficacy and safety of plasma gel (Filler) injection and comparing its result with polydiaxone (PDO) mono threads in peri-orbital rejuvenation by subjective measure using a 3D computerized camera which gives a report with very fine details. Patients and methods: 40 patients with infra-orbital fine wrinkles were included and by the Antera 3D camera, these fine wrinkles were divided to small sized and medium sized wrinkles and evaluated for the changes in the size and depth, indentation index and texture roughness of the wrinkles. Patients underwent plasma gel injections into the infra-orbital area of the left eye and PDO mono threads insertion in the right side. All patients were evaluated using the Antera camera at day (0m), after one month (1m) and after 6 months (6m) of the therapy. Results: Antera reports of the side injected with the plasma gel showed very good response. Also PDO mono threads insertion revealed marked cosmetic results, yet the efficacy of the plasma filler was superior as regards wrinkle's size, indentation index and texture roughness. .

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Section: Figure (2)mentioning

confidence: 99%

Section: Figure (2)mentioning

confidence: 99%

Comparison between Plasma gel (Filler) and Polydiaxone (PDO) Threads in Treating Fine and Medium Sized Infra-Orbital Wrinkles Using 3D Antera Camera

Hassen¹,

Diab²,

Zayed³

et al. 2023

The Egyptian Journal of Hospital Medicine

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“…PRP has been used to successfully treat chronic elbow tendinosis and refractory wounds [6][7][8], and a number of basic studies have demonstrated the favourable effectiveness of PRP in rotator cuff repair [9]. However, comparative clinical studies have reported conflicting results.…”

Section: Introductionmentioning

confidence: 99%

Clinical Evaluations of Intraoperative Injection of Platelet‐Rich Plasma in Arthroscopic Single‐Row Rotator Cuff Repair at 2‐Year Follow‐Up

Wang

Zhang

et al. 2021

BioMed Research International

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Background. The clinical evidence is conflicted on whether platelet-rich plasma (PRP) therapies have a positive effect on tendon healing and improved functional outcomes. Purpose. To evaluate the potentials of intraoperative injection PRP on the speed and quality of healing in patients undergoing arthroscopic repair for small to medium rotator cuff tears. Methods. A total of 86 patients scheduled for arthroscopic single-row repair of small to medium rotator cuff tears were assigned to undergo either PRP injection (PRP group) or conventional repair (control group). The PRP group ( N = 43 ) consisted of patients who received an intraoperative injection of liquid PRP. The control group ( N = 43 ) consisted of patients who did not receive that treatment. The visual analogue scale (VAS) for pain before treatment and at 1, 14 days, 3, 6, and 24 months after surgery were recorded. The clinical outcomes were assessed by the University of California, Los Angeles (UCLA) and Constant scores before treatment and at 3, 6, and 24 months after surgery and magnetic resonance imaging or ultrasound examination at 24 months. Patient satisfaction and retear rate were also assessed. Results. No statistical differences in baseline characteristics such as age, gender, dominant arm, and tear size were observed between the two groups ( P > 0.05 ). For the PRP group, the mean operation time was 40.22 minutes, and for the control group, the mean operation time was 36.3 minutes. There was a statistically significant difference ( P = 0.036 ). After surgery, all VAS measurements significantly decreased over time until final follow-up in both groups. No significant difference between the 2 groups was found for any VAS pain measurement at any time point except for the VAS at 1 day postoperatively, which was significantly lower in the PRP group ( 2.39 ± 1.03 ) than that in the control group ( 3.21 ± 1.85 ) ( P = 0.014 ). Analysis of the PRP and control groups demonstrated a statistically significant improvement in UCLA and Constant scores from baseline to the 3-, 6-, and 24-month follow-up assessments ( P < 0.05 ). However, no significant intergroup differences were observed in the clinical scores between the three follow-up time points ( P > 0.05 ). At the 24-month follow-up, patient satisfaction rates reached 95.65% and 93.48% for the PRP and control groups, respectively. The retear rate of the PRP group (2/43, 4.65%) was lower than that of the control group (6/43, 13.95%). Conclusions. Although the pain at 1 day after surgery and the retear rate in the PRP group were significantly lower than those in the control group, the liquid PRP injection did not promote better clinical outcomes at the 2-year follow-up.

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“…Platelet rich plasma (PRP) is considered as a source of biological active components such as growth factors and cytokines [18][19][20][21] . It is used as autologous biological treatment which stimulate normal healing cascade and tissue regeneration [22,23] . It is used in the treatment of musculoskeletal disorders [24,25] , hair loss [26] with promising results.…”

Section: Introductionmentioning

confidence: 99%

Effect of Platelet-Rich Plasma in Cyclophosphamide-Induced Ovarian Failure in Albino Rats: Histological and Anatomical Study

Shinety

Mottelib

Safwat

et al. 2021

Egyptian Journal of Histology

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Backgroud: Amenorrhea and ovarian disorders are a common concern of women under the age of 40, a condition medically known as premature ovarian failure (POF). The incidence of POF among Egyptian women before the age of 40, is about 8% that exceeds the global incidence which is about 1%. Chemotherapeutic agents were linked to toxicity of ovarian tissues and disturbance of ovarian functions. Provision of a suitable protective agent with high efficacy, low side effects and cost is a major challenge in the field of oncofertility. Aim of the Study: Is to evaluate the mechanism of PRP treatment in induced ovarian failure due to cyclophosphamide. Materials and Methods: The present study was carried out on twenty-nine albino rats. Twenty-four adult female albino rats were used as the experimental group. Five age-matched healthy male albino rats were used to get the PRP. The twenty-four adult female albino rats were randomly assigned into three groups (control, group II: received cyclophosphamide, group III: received cyclophosphamide and PRP). Plasma estradiol and progesterone levels were measured on day 22 after cyclophosphamide treatment before experimental rats euthanasia. The rats were euthanized and ovaries were anatomically examined using dissecting stereomicroscope. Sections of the ovaries were prepared and examined histologically, immunohistochemicaly and using transmission electron microscope. Results: Cyclophosphamide treated groups showed signs of degeneration of follicles and oocyte and deterioration of ovarian functions. PRP treated group showed improved appearance of ovarian follicles and improved ovarian functions. Conclusion: PRP seems to have protective effects on ovarian tissues and functions and its concomitant use with cyclophosphamide helps to restore the ovarian tissues.

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Platelet biology and the rationale of PRP therapy in chronic wounds

Cited by 10 publications

References 66 publications

Comparison between Plasma gel (Filler) and Polydiaxone (PDO) Threads in Treating Fine and Medium Sized Infra-Orbital Wrinkles Using 3D Antera Camera

Comparison between Plasma gel (Filler) and Polydiaxone (PDO) Threads in Treating Fine and Medium Sized Infra-Orbital Wrinkles Using 3D Antera Camera

Clinical Evaluations of Intraoperative Injection of Platelet‐Rich Plasma in Arthroscopic Single‐Row Rotator Cuff Repair at 2‐Year Follow‐Up

Effect of Platelet-Rich Plasma in Cyclophosphamide-Induced Ovarian Failure in Albino Rats: Histological and Anatomical Study

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