Platelet Counts in Capillary Blood

Feusner, James; Behrens, Joyce A.; Detter, James C.; Cullen, Thomas C.

doi:10.1093/ajcp/72.3.410

Cited by 19 publications

(16 citation statements)

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“…In cases of acute malaria, patients are usually febrile and vasodilated, whereas following recovery there may be peripheral vasoconstriction, leading to greater tissue fluid admixture in capillary samples. Previous studies in patients and volunteers without malaria have revealed that the haematocrit and leucocyte levels tend to be higher in capillary blood samples than in venous blood samples, while platelet numbers tend to be similar or lower [5–7,27, 34]. Haematocrit measurements have also been observed to be more variable on repeated capillary sampling than on repeated venous sampling.…”

Section: Discussionmentioning

confidence: 99%

Comparison of plasma, venous and capillary blood levels of piperaquine in patients with uncomplicated falciparum malaria

Ashley

Stepniewska

Annerberg

et al. 2010

Eur J Clin Pharmacol

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PurposeDihydroartemisinin-piperaquine (DP) is a fixed-dose artemisinin-based combination treatment. Field pharmacokinetic studies would be simplified and facilitated by being able to use small volume capillary assays rather than venous blood. The aim of this study was to describe the relationship between piperaquine concentrations measured in capillary blood, venous blood and venous plasma.MethodsSamples of plasma, whole blood obtained by venesection and capillary blood were taken simultaneously from patients with uncomplicated Plasmodium falciparum malaria treated with DP between 0 and 9 weeks after treatment. Piperaquine concentrations in venous and capillary samples were measured using solid phase extraction and analysis by liquid chromatography with ultraviolet detection.ResultsA total of 161 sets of the three measures were obtained from 54 patients. Piperaquine concentrations in the venous blood samples were approximately twofold higher and those in the capillary blood samples were threefold higher than the corresponding venous plasma concentrations. Capillary blood piperaquine concentrations were approximately 1.7-fold higher than venous blood concentrations, and this difference also increased with time.ConclusionDifferences in whole blood and plasma levels of piperaquine suggest compartmentalisation of the drug within blood cells, as also occurs with the structurally related quinoline chloroquine. The relationship between piperaquine concentrations in the venous plasma, venous blood and capillary blood is variable and unpredictable at low concentrations. However, within the range of concentrations usually present in patients between 3 and 21 days after treatment with currently recommended doses, the relationship between capillary and venous whole blood is predictable; consequently, capillary blood sampling can be used in field assessments.

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Section: Discussionmentioning

confidence: 99%

Comparison of plasma, venous and capillary blood levels of piperaquine in patients with uncomplicated falciparum malaria

Ashley

Stepniewska

Annerberg

et al. 2010

Eur J Clin Pharmacol

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“…These differences, the opposite to those found by us, are hard to explain but do not appear to be related to the use of a tourniquet, which can falsely raise venous values when used excessively (Hall & Malia 1984), as both Moe and we ourselves used one routinely in obtaining venous samples. Although our finding of higher skin puncture values is not new-for example Feusner et al (1979) presented data indicating a significantly higher skin puncture haematocrit-we are not aware of other studies which have stressed this fact or which have attempted to measure the size of the difference in skin puncture red cell values. The coefficients of variation for Hb, RBC and haematocrit previously determined for our methods using both venous and skin puncture blood (Hinchliffe et al 1985) are in each case less than the difference between the mean values, indicating a real difference between the two groups and a lack of effect on precision of the small volume of skin puncture samples.…”

Section: Discussionmentioning

confidence: 72%

“…Comparisons between skin puncture and venous blood count values in children and adults have previously been made with conflicting results regarding both Hb and RBC values (Andresen & Mugrage 1938;Moe 1970) and platelet counts (Feusner et al 1979;Mayer et al 1980;Lippi et al 1985). A study of these divergent reports prompted us to compare venous blood count data with those obtained from skin puncture samples in children being treated at this hospital.…”

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confidence: 99%

Venous and Skin puncture blood counts compared

Bellamy

Hinchliffe

1988

Clinical &Amp; Laboratory Haematology

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Venous and skin puncture blood counts were compared in 80 paired samples from 33 children, aged 6 months to 14 years, and 10 adults. Significantly higher mean values for Hb, RBC, haematocrit and neutrophils were found in skin puncture blood in children whereas platelet values were slightly higher in venous blood. Similar results were found in adult samples. Only occasionally were differences likely to be of clinical importance. The excellent comparability of paired platelet counts, at variance to that found in some previous studies, indicates that skin puncture blood can be used for platelet estimation providing an appropriate counting method is used.

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“…Another similar study [4] on healthy volunteers had shown lower platelet counts, elevated white counts and haemoglobin values in capillary blood compared to venous samples. Other studies [5,6] on platelet counts in healthy volunteers and patients with known low platelet counts noted the difference between the capillary and venous platelet counts to be higher in the healthy volunteers, while there was poor correlation between the venous and capillary samples in patients with low platelet counts. Although it is not clear why the contradiction in the results especially with regards to platelet counts, one possible explanation could be the delay in analysis of the capillary samples sent to the laboratory in the former study [4].…”

Section: Discussionmentioning

confidence: 92%

“…However, there have been conflicting results from several studies that show significant differences between the capillary and venous FBC parameters that are measured [2][3][4][5][6].…”

Section: Discussionmentioning

confidence: 99%

Comparison of Full Blood Count Parameters Using Capillary and Venous Samples in Patients Presenting to the Emergency Department

Ponampalam

Chong

Tan

2012

ISRN Emergency Medicine

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Full blood count (FBC) analysis is a common investigation done in the emergency department (ED). The aim of this study was to determine the accuracy of bedside FBC analysis using capillary blood samples from a finger stab at point of care (POC) compared to a conventional venous blood sample analysis. A total of 314 consecutive patients presenting to the ED were recruited. After consenting, a sample of the patient's venous (V) blood was obtained via venepuncture and sent to the haematology laboratory for analysis as standard practice. This was followed immediately by collection of a capillary (C) blood sample from a finger stab which was analysed at site using an automated FBC analyser at POC. Agreement between the paired samples for blood parameters including the total white cell count, hemoglobin, and platelet count was assessed by the statistical method of Bland and Altman using V sample as the gold standard. The results showed a statistically significant deviation between capillary and venous samples only for platelet counts (P < 0.001) and haemoglobin (P < 0.001). However, the magnitudes of this difference 7.3 × 109/L and 0.5 g/dL respectively, were not clinically significant. The study suggest that the analysis of capillary samples for FBC parameters is a reliable and acceptable alternative to conventional methods with the benefits of being a rapid, convenient, and minimally invasive technique.

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Platelet Counts in Capillary Blood

Cited by 19 publications

References 0 publications

Comparison of plasma, venous and capillary blood levels of piperaquine in patients with uncomplicated falciparum malaria

Comparison of plasma, venous and capillary blood levels of piperaquine in patients with uncomplicated falciparum malaria

Venous and Skin puncture blood counts compared

Comparison of Full Blood Count Parameters Using Capillary and Venous Samples in Patients Presenting to the Emergency Department

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