Platelet-derived microvesicles (PMVs) in cancer progression and clinical applications

Pan, Yan; Wang, Yingjian; Wang, Yanzhong; Xu, Shoufang; Jiang, Feiyu; Han, Yetao; Hu, Mengsi; Liu, Zhiwei

doi:10.1007/s12094-022-03014-3

Cited by 14 publications

(11 citation statements)

References 83 publications

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“…PEVs are generally regarded as cancer-promoter, but they also have the antitumor capacity in tumor progression. 37,63,64 These extracellular vesicles have been reported to play a role in tumor metastasis, regulation of immune cells, and the formation of cancer-associated thrombosis. 37,63,64 PEVs could interact directly with cancer cells, and modulate the phenotype of cancer cells.…”

Section: The Role Of Pevs In Tumor Progressionmentioning

confidence: 99%

“…37,63,64 These extracellular vesicles have been reported to play a role in tumor metastasis, regulation of immune cells, and the formation of cancer-associated thrombosis. 37,63,64 PEVs could interact directly with cancer cells, and modulate the phenotype of cancer cells. Yao et al reported that breast cancer cells would differentiate into a metastatic phenotype after the interaction of PEVs, due to the delivery of TPM-3 mRNA in PEVs.…”

Section: The Role Of Pevs In Tumor Progressionmentioning

confidence: 99%

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Platelet-derived extracellular vesicles for drug delivery

Yao¹,

Wang²

2023

Biomater. Sci.

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Section: The Role Of Pevs In Tumor Progressionmentioning

confidence: 99%

Section: The Role Of Pevs In Tumor Progressionmentioning

confidence: 99%

Platelet-derived extracellular vesicles for drug delivery

Yao¹,

Wang²

2023

Biomater. Sci.

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“…17 PMPs are significantly associated with the pathogenesis of numerous cardiovascular diseases 18 and potentially associated with tumor proliferation and metastasis. 19,20 PMPs production may indicate the stress exposure level of platelets in vivo or during preparation and storage. 21,22 Multiple studies reported that during collection, processing and storage, PMPs could be released from platelets prepared by AP, BC, and PRP processes.…”

Section: Introductionmentioning

confidence: 99%

“…High level of autologous PMPs was observed in patients with pulmonary hypertension 17 . PMPs are significantly associated with the pathogenesis of numerous cardiovascular diseases 18 and potentially associated with tumor proliferation and metastasis 19,20 …”

Section: Introductionmentioning

confidence: 99%

Comparative analysis of the quality of platelet concentrates produced by apheresis procedures, platelet rich plasma, and buffy coat

Li,

Zhao,

Chen

et al. 2024

Transfusion

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BackgroundPlatelet concentrates (PCs) could be prepared using either whole‐blood processes or apheresis instruments. During collection, processing and storage, some biochemical and functional changes occur, which may result in quality reduction. Quality evaluation of PCs may be helpful for the precise control of platelet (PLT) inventory to reduce the risk of refractoriness and adverse effects caused by platelet transfusion.Study Design and MethodsThe study was aimed to evaluate the quality of PCs which were produced by five processes: apheresis (AP) procedures (using three different cell separators: Amicus, Trima Accel and MCS+ instruments), platelet rich plasma (PRP), and buffy coat (BC). A total of 100 PCs (20 of each group) were assessed in respect of routine quality control, morphology, size distribution, destroyed and activated platelets, and production of platelet‐derived microparticles (PMPs).ResultsAll PCs have satisfied the recommended quality of volume, platelet count, residual WBC count, residual RBC count, pH, and sterility according to the Chinese Technical Manual. There was no difference among the 5 groups in morphology and size of PLT and PMPs. Dynamic light scattering test showed that apheresis PCs showed peaks around 10–20 nm, but not whole blood‐derived PCs. PCs prepared by Amicus had the relatively high percentage of destroyed platelet, activated platelets and PMPs than other groups.DiscussionThe data suggested high heterogeneity of PMPs, destroyed and activated platelets in PCs produced by different processes, which might be helpful to manage the platelet inventory for targeted use.

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“…Platelets play multiple roles in cancer progression and metastasis. Activated platelets play a mediating role in tumor growth, invasion, abnormal angiogenesis, and metastasis [4,5]. It has been proved that platelet elevation is associated with adverse outcomes of many different cancers, including gastric cancer, pancreatic cancer, ovarian cancer, and endometrial cancer [6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Prognostic Value of Platelet Distribution Width to Lymphocyte Ratio in Patients with Hepatocellular Carcinoma Following Hepatectomy

Zhong,

Liang,

et al. 2023

Preprint

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Background Platelet distribution width (PDW), but not platelet count, was found to more comprehensively reflect platelet activity. The present study, thus, aimed to evaluate the prognostic value of PDW to lymphocyte ratio (PDWLR)in patients with hepatocellular carcinoma (HCC) following hepatectomy. MethodsPatients following hepatectomy were analyzed retrospectively. The Kaplan-Meier survival curves and Cox regression model were used to determine the prognostic value of PDWLR. Results241 patients were analyzed eventually, and stratified into low and high PDWLR groups (≤ 9.66 vs. > 9.66). Results of comparing the baseline characteristics showed that high PDWLR was significantly associated with cirrhosis, and intraoperative blood loss (all P < 0.05). In multivariate COX regression analysis, PDWLR was demonstrated as an independent risk factor for OS (HR: 1.549, P = 0.041) and RFS (HR: 1.655, P = 0.005). Moreover, PDWLR demonstrated a superior capacity for predicting prognosis compared to other indicators. Conclusion Preoperative PDWLR has a potential value in predicting the prognosis of HCC patients following hepatectomy, which may help in clinical decision-making for individual treatment.

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Platelet-derived microvesicles (PMVs) in cancer progression and clinical applications

Cited by 14 publications

References 83 publications

Platelet-derived extracellular vesicles for drug delivery

Platelet-derived extracellular vesicles for drug delivery

Comparative analysis of the quality of platelet concentrates produced by apheresis procedures, platelet rich plasma, and buffy coat

Prognostic Value of Platelet Distribution Width to Lymphocyte Ratio in Patients with Hepatocellular Carcinoma Following Hepatectomy

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