Platelet-derived porous nanomotor for thrombus therapy

Abstract

The treatment difficulties of venous thrombosis include short half-life, low utilization, and poor penetration of drugs at thrombus site. Here, we develop one kind of mesoporous/macroporous silica/platinum nanomotors with platelet membrane (PM) modification (MMNM/PM) for sequentially targeting delivery of thrombolytic and anticoagulant drugs for thrombus treatment. Regulated by the special proteins on PM, the nanomotors target the thrombus site and then PM can be ruptured under near-infrared (NIR) irradiation to achieve desirable sequential drug release, including rapid release of thrombolytic urokinase (3 hours) and slow release of anticoagulant heparin (>20 days). Meantime, the motion ability of nanomotors under NIR irradiation can effectively promote them to penetrate deeply in thrombus site to enhance retention ratio. The in vitro and in vivo evaluation results confirm that the synergistic effect of targeting ability from PM and motion ability from nanomotors can notably enhance the thrombolysis effect in both static/dynamic thrombus and rat model.

Medical Micro/Nanorobots in Precision Medicine

“…[ 217 ] In vivo studies using near infrared powered nanorobot reported an increased efficacy urokinase toward thrombus therapy, when compared to passive delivery. [ 218 ] Chemically triggered microrobots do not require external stimuli to improve the therapeutic outcome. Therefore, they do not need expensive and bulky external systems commonly used for triggering other active delivery, such as occurring with previously described magnetic micromotors.…”

Nanomotor-based adsorbent for blood Lead(II) removal in vitro and in pig models

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Self‐Propelled Micro/Nanomotors for Tumor Targeting Delivery and Therapy

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