Platelet Distribution Width as a Predictor of Metastasis in Gastric Cancer Patients

Günaldı, Meral; Erdem, Dilek; Göksu, Sema Sezgin; Gündüz, Şeyda; Okuturlar, Yıldız; Tiken, Eda; Aksoy, Hüseyin; Yıldırım, Mustafa

doi:10.1007/s12029-016-9886-5

Cited by 18 publications

(13 citation statements)

References 16 publications

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“…Increased PDW was found in gastric cancer and lung cancer [21,22], and has been demonstrated to have a poor prognostic impact in melanoma, thyroid cancer, colorectal cancer, and laryngeal cancer. Also, studies, found that an increased PDW was associated with advanced TNM stages and shortened OS in patients with nasopharyngeal cancer.…”

Section: Discussionmentioning

confidence: 99%

Low platelet to lymphocyte ratio and high platelet distribution width have an inferior outcome in chronic lymphocytic leukaemia patients

El-Ashwah

Denewer

Niazy

et al. 2020

Nowotwory. Journal of Oncology

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Introduction. Chronic lymphocytic leukaemia (CLL) is an incurable disease of the elderly, characterised by gradual accumulation of small mature B lymphocytes which escape apoptosis through inflammatory signals from the microenvironment. Elevated inflammatory markers are associated with very poor prognosis in different types of cancer. Therefore, we examined retrospectively the impact of platelet lymphocyte ratio (PLR) and platelet distribution width (PDW) on 180 CLL patients' outcome. Materials and methods. This retrospective study included 180 patients with CLL who were diagnosed and selected among cases referred to the Oncology Center Mansoura University between January 1 st , 2008 and June 30 th , 2016. All the relevant information was collected from the electronic medical records of the selected patients. Results. Our results revealed that low PLR (<2.5) was more frequently observed in patients with stage C (p < 0.001), with 17p deletion (p = 0.017), and CD38 expression (p = 0.08), but not with seropositive HCV patients (p = 0.2). High PDW (≥18.5 fl) was more frequently associated with intention to treat population (p = 0.038), and CD38 expression (p = 0.068), but not with 17p deletion (p = 0.25) and seropositive HCV patients (p = 0.4). Multivariate analysis for overall survival showed that stage A and low PDW were independent factors for overall survival (p = 0.014 and 0.04 respectively), while high PLR (p = 0.05), and seronegative HCV patients (p = 0.1) lost their significance. Conclusion. Our data showed that low PLR and high PDW were associated with poor prognostic markers. Stage C-CLL and high PDW were independent predictors of survival.

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Section: Discussionmentioning

confidence: 99%

Low platelet to lymphocyte ratio and high platelet distribution width have an inferior outcome in chronic lymphocytic leukaemia patients

El-Ashwah

Denewer

Niazy

et al. 2020

Nowotwory. Journal of Oncology

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“…[ 24 ] In the case of gastrointestinal malignancies like gastric cancer, increase PDW was found to be associated with metastasis. [ 25 ] Inconsistency in PDW association with the cancers may partly be attributed to type of cancer and partly to ethnicity.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of platelet distribution width as novel biomarker in gall bladder cancer

Siddeek

Gupta

et al. 2020

J Carcinog

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INTRODUCTION: Gall bladder cancer (GBC) tends to present in advanced stages, therefore, early diagnosis of GBC is necessary. There is no ideal single tumor marker available presently for the diagnosis and prognosis of GBC. Platelet distribution width (PDW) is an early marker for activated platelets and has been used in a variety of tumors to assess prognosis. This study was designed to evaluate the utility of PDW in identifying GBC patients and its association with tumor markers, staging and resectability of GBC. MATERIALS AND METHODS: This cross sectional study was done on 100 patients of GBC and 100 age- and sex- matched healthy controls. PDW was evaluated and compared between GBC and healthy controls. Receiver-operating characteristics was plotted to determine optimal cut-off for identifying GBC patients and to determine sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of PDW. Correlation between serum tumor markers (carbohydrate antigen 19-9, carcinoembryonic antigen, and carbohydrate antigen 125) and PDW were evaluated. Association of PDW with hyperbilirubinemia, staging and resectability of GBC was also studied. RESULTS: A significantly higher PDW with a median of 18.1 was observed in GBC as compared to healthy controls with median value of 13. PDW was found to have a very high sensitivity (90%), specificity (95%), PPV (94%) and NPV (90%) in identifying GBC at cut-off of 16 with area under the curve (AUC) of 0.97. An increase of PDW was observed with increasing stage and unresectable GBC. However, it was not statistically significant. Significant positive correlation was observed between PDW and all three serum tumor markers and good positive correlation with r = 0.61 was observed with CA 19-9. CONCLUSION: PDW was associated with GBC and may be considered as a cost- effective marker in adjunct to other investigations for the diagnosis of GBC.

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“…54 In normal individuals, there was a linear correlation between PDW and MPV, while in patients with cancer, there was no parallel relationship between them. 55 Previous studies showed that PDW is associated with poor prognosis in NSCLC, 56 gastric cancer, 57,58 and melanoma. 59 The statement on PDW is controversial in different cancer research, and the significance between PDW and malignancy has not been deeply explored.…”

Section: Discussionmentioning

confidence: 99%

Prognostic Values of Platelet-Associated Indicators in Resectable Cervical Cancer

Wang

Huang

et al. 2019

Dose-Response

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Background:Cervical cancer is one of the leading causes of cancer mortality in women, which seriously threatens the health of women worldwide. Platelet (PLT)-related parameters, including PLT count, mean platelet volume (MPV), plateletcrit (PCT), and platelet distribution width (PDW), are correlated with tumor prognosis.Methods:In total, 110 patients with cervical carcinoma were recruited in this study. The patients were divided into 2 groups according to the receiver operating characteristic analysis cutoff values of PLT, MPV, PCT, or PDW. The post-/preradiotherapy ratios were defined as the rate of preradiotherapy PLT-related parameters counts and the corresponding ones obtained after radiotherapy.Results:Higher pretreatment PLT level was correlated with Higher Federation of Gynecology and Obstetrics (FIGO) stage (II). Higher pretreatment PLT level was correlated with worse progression-free survival (PFS) and overall survival (OS). Increased post-/preradiotherapy ratio of PLT was correlated with worse PFS and OS. Changes in PCT, MPV, or PDW levels had no effects on PFS or OS. Cox regression analysis model indicated that larger tumor size, higher pretreatment PLT level, and increased post-/preradiotherapy PLT ratio were independently associated with worse PFS; higher FIGO stage (II) and increased post-/preradiotherapy PLT ratio were independently associated with worse OS.Conclusion:Pretreatment PLT level and increased post-/preradiotherapy PLT ratio are correlated with outcomes of cervical cancer.

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Platelet Distribution Width as a Predictor of Metastasis in Gastric Cancer Patients

Cited by 18 publications

References 16 publications

Low platelet to lymphocyte ratio and high platelet distribution width have an inferior outcome in chronic lymphocytic leukaemia patients

Low platelet to lymphocyte ratio and high platelet distribution width have an inferior outcome in chronic lymphocytic leukaemia patients

Evaluation of platelet distribution width as novel biomarker in gall bladder cancer

Prognostic Values of Platelet-Associated Indicators in Resectable Cervical Cancer

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