Platelet distribution width (PDW) data of patients with nasal polyposis: is it important for clinical severity?

Kepekçi, Ahmet Hamdi; Dizdar, Gökalp; Kepekçi, Ali Bestemi

doi:10.2399/jmu.2017001002

Cited by 2 publications

(2 citation statements)

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“…Different results were reported by other investigators who demonstrated that the neither MPV nor PDW differed between asthmatic patients and controls, or between exacerbated-asthmatics and stable-asthmatics [19,21,24,31,32]. Kepekçi et al [33] found a weak, positive, directional, and meaningful relationship between PDW and MPV variables in patients with nasal polyposis with or without asthma. These controversies between studies regarding the value of platelet indices in bronchial asthma may be owing to different population under concern, different patient age, different attack severity, and different measurement methods.…”

Section: Discussionmentioning

confidence: 56%

Assessment of bronchial asthma exacerbation: the utility of platelet indices

et al. 2019

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Background Activated platelets and platelet indices have a vital role in bronchial hyper-responsiveness, bronchoconstriction, bronchial inflammation, airway remodeling, angiogenesis, allergic reactions, and repair and renewal of tissues; platelets contain mediators that lead to inflammatory response. AimThe aim was to assess the use of platelet indices [mean platelet volume (MPV), platelet distribution width (PDW), plateletcrit (PCT), and platelet large cell ratio (PLCR)] as cheap and readily available biomarkers for bronchial asthma exacerbation.Patients and methods A case-control study involved 45 bronchial asthma female patients during both stable and exacerbation phases, and 45 age-matched healthy female patients as a control group. Measurements of platelet counts, MPV, PDW, PCT, PLCR, C-reactive protein (CRP), spirometric indices, and arterial blood gases were performed for all participants.Results The MPV and PDW were significantly lower, whereas the PCT and PLCR were considerably higher in exacerbation phase compared with stable phase and in stable phase in comparison with controls (P<0.001). The MPV and PDW were negatively correlated with white blood cells, PaCO 2 , symptoms duration, and hs-CRP (high sensitive), with positive correlation with forced expiratory volume in the first second and PaO 2 (P<0.001). PCT and PLCR were positively correlated with white blood cells, PaO 2 , and symptoms duration, and negatively correlated with forced expiratory volume in the first second, symptoms duration, and hs-CRP (P<0.001). ConclusionThe platelet indices were altered in exacerbation phase compared with stable phase and control group. Therefore, clinicians should not ignore interpreting platelet indices during asthma exacerbation, especially as these tests are simple, readily available, and of lower cost. It appears that measurement of the platelet indices is a valuable indicator of asthma severity/activity and appears as a useful screening test for asthma exacerbation.

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Section: Discussionmentioning

confidence: 56%

Assessment of bronchial asthma exacerbation: the utility of platelet indices

et al. 2019

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“…In the recent studies of Ozturk et al PDW has been found to be associated with several clinical situations [31]. In the literature review, high PDW levels were found in coronary artery disease, benign paroxysmal positional vertigo, pulmonary embolism, acute gangrenous appendicitis, obstructive sleep apnoea syndrome, preeclampsia, and preterm labor, in patients with nasal polyposis [32,33]. Ozturk et al studied 175 patients with inflammatory bowel disease and found that there was a statistically significant decrease in PDW levels during disease exacerbation compared to healthy control subjects [31].…”

Section: Discussionmentioning

confidence: 99%

MPV and PDW as inflammatory indicators in chronic otitis media with effusion

Kepekçi¹

2018

biomedicalresearch

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Objectives: Chronic Otitis Media with Effusion (COME) is a clinical condition characterized by an effusion in the tympanic cavity. In this retrospective study, we aimed to compare the MPV and PDW value of patients with chronic otitis media with effusion (COMA) to those in healthy subjects as an inflammatory indicator. Materials and methods: Demographic features: age, race and gender and laboratory parameters; White Blood Cell count (WBC), Red Blood Cell count (RBC), Hemoglobin (Hb), Hematocrit (Hct), Platelets (PLT), MPV and PDW were recorded after obtaining from the computerized database. Results: We included 149 patients who underwent ventilation tube insertion between with those of age and sex compatible 151 healthy subjects into the study. In our study no statistically significant differences were identified between paediatric patients diagnosed with COME and healthy controls in terms of WBC, RBC, Hb, Hct, and MPV levels (p>0.05). However, we found significant differences both the platelet count (p<0.05) and PDW levels (p<0.001) between the COME and control group. Conclusion: This study is the first to evaluate the relationship between PDW and COME. With regards to clinical and laboratory findings, novel inflammatory markers derived from routine hemogram test may be used.

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Platelet distribution width (PDW) data of patients with nasal polyposis: is it important for clinical severity?

Cited by 2 publications

References 24 publications

Assessment of bronchial asthma exacerbation: the utility of platelet indices

Assessment of bronchial asthma exacerbation: the utility of platelet indices

MPV and PDW as inflammatory indicators in chronic otitis media with effusion

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