Platelet Factor 4 (PF4) Release during Human Platelet Aggregation in Diabetic Patients

Chmielewski, J; Farbiszewski, R

doi:10.1055/s-0038-1654225

Cited by 20 publications

(6 citation statements)

References 8 publications

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“…Fibrin monomer complexes have been found to be elevated in our young diabetics and the results suggest that these are related to elevation of betalipoprotein levels, possibly because fatty acids and lipids promote platelet aggregation (Hoak, Warner & Connor, 1967). Indeed it has recently been reported that platelet factor IV release from platelets is greater in diabetics (Chmielewski & Farbiszewski, 1970) no doubt because coating of platelets by betalipoprotein enhances their sensitivity to aggregating agents.…”

Section: Discussionmentioning

confidence: 63%

Some chemical indices of diabetic vascular disease

Wardle

Piercy

Anderson

1973

Postgraduate Medical Journal

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Summary Some chemical indices which could be related to diabetic complications have been assessed in 105 diabetics. In juvenile (insulin-dependent) diabetics with retinopathy, cardiovascular disease or nephropathy, levels of fibrinogen, fibrin monomer, beta-lipoprotein, cholesterol and alpha-2-macroglobulin were raised. Only in part is the explanation due to a rise of fibrinogen and cholesterol with age. Among twenty-six patients with a plasma fibrinogen over 400 mg/100 ml, eleven sustained a major cardiovascular catastrophe within the next 2 years. Alpha-1-acid-glycoprotein was raised in these eleven and beta-2-glycoprotein generally in juveniles with cardiovascular disease. Triglycerides were elevated in all groups, but notably in patients with Grade I retinopathy with venous dilation. There was a suggestion that triglycerides were related inversely to dietary carbohydrate in mature onset diabetics, and serum cholesterol in juveniles was related to insulin dosage. The part of lipids in vascular disease is then discussed. An interesting positive correlation was found between fibrin monomer, itself an indication of in vivo thrombin formation, and beta-lipoprotein. Although alpha-2-macroglobulin was elevated in juveniles, especially with complications, this did not apply to maturity onset cases and therefore no direct relation to diabetic vascular disease can be suggested. Moreover, alpha-2-macroglobulin levels were normal in acromegaly.

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Section: Discussionmentioning

confidence: 63%

Some chemical indices of diabetic vascular disease

Wardle

Piercy

Anderson

1973

Postgraduate Medical Journal

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“…The aspects of platelet function found to be deranged include adhesion (24), in vitro aggregability (25) and sensitivity to antiaggregating agents (26), a-granule content discharge (27,28), and thromboxane production (29). Such an activation was initially considered secondary to the presence of micro-and macroangiopathic alterations and/or to a condition of hyperglycemia (30).…”

Section: Conclusion-mentioning

confidence: 99%

Deranged Platelet Calcium Homeostasis in Poorly Controlled IDDM Patients

et al. 1993

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“…In creased plasma BTG levels in diabetic pa tients are reported by a number of authors [6][7][8][9], although no significant difference as to BTG levels in normal subjects and in dia betic patients with complications was shown to occur by Campbell et al [10].…”

Section: Introductionmentioning

confidence: 99%

Enhanced Platelet Release Reaction in Insulin-Dependent and Insulin-Independent Diabetic Patients

Davı̀

Rini

Averna

et al. 1982

Pathophysiol Haemos Thromb

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Plasma beta thromboglobulin (BTG) and platelet factor 4 (PF4) levels were measured and correlated with plasma lipid and lipoprotein patterns in 20 insulin-independent diabetics, in 10 insulin-dependent diabetics and in 30 healthy controls matched to patients as to age, sex and weight. Increased plama BTG and PF4 levels both in insulin-dependent and in insulin-independent diabetics indicate enhanced in vivo platelet activation and release reaction in these patients. No difference in BTG and PF4 values between these two groups of diabetic patients was observed in our study. A marked correlation between plasma PF4 values and plasma glucose levels was shown in insulin-dependent diabetics only whereas a significant positive correlation with plasma triglycerides and plasma triglyceride VLDL and a negative correlation with cholesterol-HDL was shown in insulin-independent diabetics.

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Platelet Factor 4 (PF4) Release during Human Platelet Aggregation in Diabetic Patients

Cited by 20 publications

References 8 publications

Some chemical indices of diabetic vascular disease

Some chemical indices of diabetic vascular disease

Deranged Platelet Calcium Homeostasis in Poorly Controlled IDDM Patients

Enhanced Platelet Release Reaction in Insulin-Dependent and Insulin-Independent Diabetic Patients

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