Platelet function in hypertension

Haouari, Mohammed El; Rosado, Juan A.

doi:10.1016/j.bcmd.2008.07.003

Cited by 73 publications

(51 citation statements)

References 119 publications

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“…Since then, platelets have been extensively used in pharmacological studies addressing the mechanism of action of centrally active drugs. Platelets and neurons share several homeostatic functions, such as the accumulation and release of neurotransmitters, responsiveness to variations in calcium concentration, and expression of membranebound compounds (e.g., receptors and enzymes) [8] . The platelet membrane contains several types of surface receptors that respond to external stimuli yielding activating or inhibitory responses [9] and thus modulating the main homeostatic function of thrombocytes, which is to halt the loss of blood from injured vessels.…”

Section: Topic Highlightmentioning

confidence: 99%

Platelet biomarkers in Alzheimer’s disease

Talib

Joaquim²,

Forlenza³

2012

WJP

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The search for diagnostic and prognostic markers in Alzheimer's disease (AD) has been an area of active research in the last decades. Biochemical markers are correlates of intracerebral changes that can be identified in biological fluids, namely: peripheral blood (total blood, red and white blood cells, platelets, plasma and serum), saliva, urine and cerebrospinal fluid. An important feature of a biomarker is that it can be measured objectively and evaluated as (1) an indicator of disease mechanisms (markers of core pathogenic processes or the expression of downstream effects of these processes), or (2) biochemical responses to pharmacological or therapeutic intervention, which can be indicative of disease modification. Platelets have been used in neuropharmacological models since the mid-fifties, as they share several homeostatic functions with neurons, such as accumulation and release of neurotransmitters, responsiveness to variations in calcium concentration, and expression of membrane-bound compounds. Recent studies have shown that platelets also express several components related to the pathogenesis of AD, in particular to the amyloid cascade and the regulation of oxidative stress: thus they can be used in the search for biomarkers of the disease process. For instance, platelets are the most important source of circulating forms of the amyloid precursor protein and other important proteins such as Tau and glycogen synthase kinase-3B. Moreover, platelets express enzymes involved in membrane homeostasis (e.g., phospholipase A2), and markers of the inflammatory process and oxidative stress. In this review we summarize the available literature and discuss evidence concerning the potential use of platelet markers in AD.

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Section: Topic Highlightmentioning

confidence: 99%

Platelet biomarkers in Alzheimer’s disease

Talib

Joaquim²,

Forlenza³

2012

WJP

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“…Indirect information can be drawn from the study of Spencer et al, which showed that PC was not increased in patients with hypertension 34 . Other studies in this field have only examined the relationship between BP and platelet activity, which is not the same as PC 35 . Our study is believed to be the first to examine this relationship in a large cohort of elderly patients.…”

Section: Discussionmentioning

confidence: 95%

Association Between Platelet Count and Components of Metabolic Syndrome in Geriatric Taiwanese Women

Chen

Hsu

Hseih

et al. 2012

International Journal of Gerontology

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“…Specifically, aberrant calcium signaling in platelets has been reported in diabetic and hypertensive individuals and may be a factor in their disease progression (56,57). The precise details of the molecular mechanisms of how dematin positively regulates calcium release from the DTS in platelets remain to be elucidated.…”

Section: Discussionmentioning

confidence: 99%

Headpiece Domain of Dematin Regulates Calcium Mobilization and Signaling in Platelets

Wieschhaus

Breton

Chishti

2012

Journal of Biological Chemistry

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Background: Dematin is a major component of the erythrocyte membrane. Its abundance in platelets suggests a conserved function. Results: Dematin regulates calcium mobilization in platelets. Mice lacking the dematin headpiece domain show multiple defects in platelet function. Conclusion: Dematin emerges as a new regulator of calcium mobilization in platelets. Significance: Inhibition of dematin interactions may offer new therapeutic approaches against platelet activation and cardiovascular diseases.

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Platelet function in hypertension

Cited by 73 publications

References 119 publications

Platelet biomarkers in Alzheimer’s disease

Platelet biomarkers in Alzheimer’s disease

Association Between Platelet Count and Components of Metabolic Syndrome in Geriatric Taiwanese Women

Headpiece Domain of Dematin Regulates Calcium Mobilization and Signaling in Platelets

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