2004
DOI: 10.1111/j.1538-7836.2004.01009.x
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Platelet function in sepsis

Abstract: Summary. Background: Coagulation abnormalities and thrombocytopenia are common in severe sepsis, but sepsis-related alterations in platelet function are ill-defined. Objectives: The purpose of this study was to elucidate the effect of sepsis on platelet aggregation, adhesiveness, and growth factor release. Patients and methods: Agonist-induced platelet aggregation was measured in platelet-rich plasma separated from blood samples collected from 47 critically ill patients with sepsis of recent onset. Expression … Show more

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Cited by 159 publications
(119 citation statements)
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“…The MA value was significantly reduced in this mouse cohort, a result of the diminished platelet counts in the LPS-treated WT group and/or by a possible acquired platelet dysfunction known to occur with sepsis. 26 A very profound effect of LPS administration on whole blood clotting of LPS-treated PC Ϫ/Ϫ PC(tg4)/TF Ϫ/Ϫ hTF(tg) mice was observed, wherein no coagulation was observed up to 120 hours after recalcification. This result is consistent with the prolonged aPTT data ( Figure 2B), compounded by reduced platelets inhibiting a stable clot from forming.…”
Section: Discussionmentioning
confidence: 96%
“…The MA value was significantly reduced in this mouse cohort, a result of the diminished platelet counts in the LPS-treated WT group and/or by a possible acquired platelet dysfunction known to occur with sepsis. 26 A very profound effect of LPS administration on whole blood clotting of LPS-treated PC Ϫ/Ϫ PC(tg4)/TF Ϫ/Ϫ hTF(tg) mice was observed, wherein no coagulation was observed up to 120 hours after recalcification. This result is consistent with the prolonged aPTT data ( Figure 2B), compounded by reduced platelets inhibiting a stable clot from forming.…”
Section: Discussionmentioning
confidence: 96%
“…Blood rheology and platelet function are progressively and severely altered in patients with severe sepsis. 49,50 Evidence suggests a prominent role for inappropriate platelet activation and aggregation during sepsis, 51 and platelet indices beyond platelet count are useful to evaluate illness severity and prospectively identify critically ill patients. 52,53 In this regard, sGPVI represents an excellent candidate marker of pathological platelet activation in the setting of sepsis, as it is a platelet/megakaryocytespecific membrane protein that is stable on circulating platelets but released on ligand engagement of ITAM receptors, exposure to FXa, or abnormal fluid shear rates.…”
Section: Discussionmentioning
confidence: 99%
“…Its name "platelet-derived," is misleading due to the fact that the endothelium presents the major source of PDGF during sepsis (Battegay et al 1994;Thommen et al 1997;Yaguchi et al 2004). The PDGF family compromises four different members, PDGF-A, -B, -C, and -D, forming biological active homodimers (Betsholtz 2003).…”
Section: Pdgfmentioning
confidence: 99%