Platelet functions and fatty acid composition of platelet phospholipids in spontaneously hypertensive rats fed saturated or polyunsaturated fats

McGregor, Lilian; Morazain, R.; Renaud, S.

doi:10.1016/0021-9150(81)90110-6

Cited by 34 publications

(5 citation statements)

References 15 publications

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“…Prostaglandin E,, 10" 7 M, did not exert any effect on thrombin-induced secretion of serotonin in the absence of external Mg 2+ but decreased it (by about 30%) in the presence of 10" 3 M external Mg 2+ concen- 2+ exerts a physiological modulatory role that may be altered in SHR. The hyperreactivity to thrombin and ADP observed in our washed platelet preparation agrees with the hyperaggregability described in platelet rich plasma of SHR 13 and with the recently described increased aggregation of washed platelets from SHR in response to ADP and collagen.…”

Section: Methodssupporting

confidence: 77%

Hyperreactivity of platelets from spontaneously hypertensive rats. Role of external magnesium.

Baudouin-Legros¹,

Dard²,

Guicheney³

1986

Hypertension

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Received February 5, 1985; accepted February 4, 1986. lease their granular content in a manner similar to that of nerve terminals. The aim of the present study was to determine whether platelet reactivity was altered in spontaneously hypertensive rats (SHR) and, if so, whether this alteration existed at the prehypertensive stage. In addition, we compared the functional response of platelets from hypertensive and control Wistar-Kyoto rats (WKY) to different external calcium concentrations to define the mechanism (or mechanisms) involved in the difference.Finally

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Section: Methodssupporting

confidence: 77%

Hyperreactivity of platelets from spontaneously hypertensive rats. Role of external magnesium.

Baudouin-Legros¹,

Dard²,

Guicheney³

1986

Hypertension

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“…Two groups have demonstrated increased microviscosity in platelet and erythrocyte ghosts in the spontaneously hypertensive 11-178 SUPPL II HYPERTENSION, VOL 8, No 6, JUNE 1986 rat model of essential hypertension. 20 " 22 In addition, McGregor and colleagues 22 showed that platelets from spontaneously hypertensive rats aggregated in response to lower concentrations of thrombin or ADP than did platelets from Wistar-Kyoto controls and that this difference was potentiated by feeding the animals diets rich in saturated fats. A decrease in erythrocyte deformability and an increase in erythrocyte membrane microviscosity have been reported in patients with essential hypertension.…”

Section: Platelet Lipid Analysismentioning

confidence: 99%

Preliminary observations on abnormalities of membrane structure and function in essential hypertension.

Naftilan¹,

Dzau²,

Loscalzo³

1986

Hypertension

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SUMMARY To test the hypothesis that structural abnormalities exist in the cell membrane in persons with essential hypertension and that these abnormalities affect membrane-related cellular functions, we examined several membrane-dependent phenomena and membrane lipid composition in the blood cells of subjects with essential hypertension. We analyzed platelet aggregability, membrane fluidity, membrane fatty acid composition, and erythrocyte deforinability in four normolipidemic subjects with untreated essential hypertension and in five age-matched normotensive controls. As compared with the controls, the subjects with essential hypertension had platelets that aggregated at lower concentrations of adenosine 5-diphosphate, platelet membranes that were less fluid, and erythrocytes that were more deformable. Lipid analysis of the membranes of platelets from the two study groups showed that although the cholesterol content was identical, the membranes from the essential hypertension group contained significantly less linoleic acid (18:2) than did those from the normotensive controls. Given the known effects of c/s-unsaturated fatty acyl composition on membrane fluidity and membrane-related cellular functions, these data suggest that one factor contributing to essential hypertension is an inherent structural membrane abnormality that alters the physical and functional properties of the cell membrane.

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“…Meanwhile the view has been put forward in the literature that changes in membranes of different cells may take place in the same direction. For instance, changes in the fatty-acid composition of dietary fats cause corresponding changes in the membranes of many cells in the body, and this affects the degree of orderliness of arrangement of the hydrocarbon chains of the fatty acids [8]. Feeding animals with cholesterol causes an increase in its concentration in membranes of different types, and a decrease in activity of the lipid-dependent membrane enzyme Na,K-ATPase has been demonstrated both in plasma membranes of the brain [I] and in erythrocyte membranes, with a simultaneous decrease in fluidity of the membranes as revealed by EPR studies of spin probes [4].…”

mentioning

confidence: 99%

Changes in structure and activity of ATPase in erythrocyte membranes in angiographically confirmed coronary disease

Artemova¹,

Torkhovskaya²,

Khodzhakuliev³

et al. 1984

Bull Exp Biol Med

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Platelet functions and fatty acid composition of platelet phospholipids in spontaneously hypertensive rats fed saturated or polyunsaturated fats

Cited by 34 publications

References 15 publications

Hyperreactivity of platelets from spontaneously hypertensive rats. Role of external magnesium.

Hyperreactivity of platelets from spontaneously hypertensive rats. Role of external magnesium.

Preliminary observations on abnormalities of membrane structure and function in essential hypertension.

Changes in structure and activity of ATPase in erythrocyte membranes in angiographically confirmed coronary disease

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